Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting
Microtubule-associated serine/threonine kinase-like (MASTL; Greatwall) is a well-characterized kinase, whose catalytic role has been extensively studied in relation to cell-cycle acceleration. Importantly, MASTL has been implicated to play a substantial role in cancer progression and subsequent stud...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/7/1624 |
| _version_ | 1827713653732802560 |
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| author | James Ronald William Conway Elisa Närvä Maria Emilia Taskinen Johanna Ivaska |
| author_facet | James Ronald William Conway Elisa Närvä Maria Emilia Taskinen Johanna Ivaska |
| author_sort | James Ronald William Conway |
| collection | DOAJ |
| description | Microtubule-associated serine/threonine kinase-like (MASTL; Greatwall) is a well-characterized kinase, whose catalytic role has been extensively studied in relation to cell-cycle acceleration. Importantly, MASTL has been implicated to play a substantial role in cancer progression and subsequent studies have shown that MASTL is a significant regulator of the cellular actomyosin cytoskeleton. Several kinases have non-catalytic properties, which are essential or even sufficient for their functions. Likewise, MASTL functions have been attributed both to kinase-dependent phosphorylation of downstream substrates, but also to kinase-independent regulation of the actomyosin contractile machinery. In this review, we aimed to highlight the catalytic and non-catalytic roles of MASTL in proliferation, migration, and invasion. Further, we discussed the implications of this dual role for therapeutic design. |
| first_indexed | 2024-03-10T18:40:01Z |
| format | Article |
| id | doaj.art-d3a8cc4601b244ccb29d4dfa144e8bcb |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T18:40:01Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-d3a8cc4601b244ccb29d4dfa144e8bcb2023-11-20T05:57:55ZengMDPI AGCells2073-44092020-07-0197162410.3390/cells9071624Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL TargetingJames Ronald William Conway0Elisa Närvä1Maria Emilia Taskinen2Johanna Ivaska3Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, FinlandTurku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, FinlandTurku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, FinlandTurku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, FinlandMicrotubule-associated serine/threonine kinase-like (MASTL; Greatwall) is a well-characterized kinase, whose catalytic role has been extensively studied in relation to cell-cycle acceleration. Importantly, MASTL has been implicated to play a substantial role in cancer progression and subsequent studies have shown that MASTL is a significant regulator of the cellular actomyosin cytoskeleton. Several kinases have non-catalytic properties, which are essential or even sufficient for their functions. Likewise, MASTL functions have been attributed both to kinase-dependent phosphorylation of downstream substrates, but also to kinase-independent regulation of the actomyosin contractile machinery. In this review, we aimed to highlight the catalytic and non-catalytic roles of MASTL in proliferation, migration, and invasion. Further, we discussed the implications of this dual role for therapeutic design.https://www.mdpi.com/2073-4409/9/7/1624MASTLactincontractilitycell cyclecancertherapeutic targeting |
| spellingShingle | James Ronald William Conway Elisa Närvä Maria Emilia Taskinen Johanna Ivaska Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting Cells MASTL actin contractility cell cycle cancer therapeutic targeting |
| title | Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting |
| title_full | Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting |
| title_fullStr | Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting |
| title_full_unstemmed | Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting |
| title_short | Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting |
| title_sort | kinase independent functions of mastl in cancer a new perspective on mastl targeting |
| topic | MASTL actin contractility cell cycle cancer therapeutic targeting |
| url | https://www.mdpi.com/2073-4409/9/7/1624 |
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