Looking to the metabolic landscapes for prostate health monitoring
Abnormal metabolism is a widely accepted biological signature of prostatic diseases, including prostate cancer and benign prostate hyperplasia. Recently accumulated epidemiological and experimental evidence illustrate that the metabolic syndrome, impaired mitochondrial function, and prostatic pathol...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2017-09-01
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| Series: | Prostate International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2287888217300442 |
| _version_ | 1797725633505132544 |
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| author | Wun-Jae Kim Jayoung Kim |
| author_facet | Wun-Jae Kim Jayoung Kim |
| author_sort | Wun-Jae Kim |
| collection | DOAJ |
| description | Abnormal metabolism is a widely accepted biological signature of prostatic diseases, including prostate cancer and benign prostate hyperplasia. Recently accumulated epidemiological and experimental evidence illustrate that the metabolic syndrome, impaired mitochondrial function, and prostatic pathological conditions intersect. The perturbed metabolism and metabolic mediates influence key signaling pathways in various prostatic pathological conditions. This short review article aids to highlight recent findings on metabolism, metabolic mechanisms, and mitochondrial metabolism as a possible route to finding a cure for prostate diseases, including prostate cancer. The effort to better understand the role that mitochondria plays in cancer metabolism and the biological meaning of defective and/or deleted mitochondrial DNA in cancer will also be discussed. |
| first_indexed | 2024-03-12T10:34:04Z |
| format | Article |
| id | doaj.art-d3a8fadcb3164c459640de5d9d804a51 |
| institution | Directory Open Access Journal |
| issn | 2287-8882 |
| language | English |
| last_indexed | 2024-03-12T10:34:04Z |
| publishDate | 2017-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Prostate International |
| spelling | doaj.art-d3a8fadcb3164c459640de5d9d804a512023-09-02T08:59:37ZengElsevierProstate International2287-88822017-09-0153858810.1016/j.prnil.2017.03.004Looking to the metabolic landscapes for prostate health monitoringWun-Jae Kim0Jayoung Kim1Department of Urology, Chungbuk National University College of Medicine, Cheongju, South KoreaDepartments of Surgery and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USAAbnormal metabolism is a widely accepted biological signature of prostatic diseases, including prostate cancer and benign prostate hyperplasia. Recently accumulated epidemiological and experimental evidence illustrate that the metabolic syndrome, impaired mitochondrial function, and prostatic pathological conditions intersect. The perturbed metabolism and metabolic mediates influence key signaling pathways in various prostatic pathological conditions. This short review article aids to highlight recent findings on metabolism, metabolic mechanisms, and mitochondrial metabolism as a possible route to finding a cure for prostate diseases, including prostate cancer. The effort to better understand the role that mitochondria plays in cancer metabolism and the biological meaning of defective and/or deleted mitochondrial DNA in cancer will also be discussed.http://www.sciencedirect.com/science/article/pii/S2287888217300442 |
| spellingShingle | Wun-Jae Kim Jayoung Kim Looking to the metabolic landscapes for prostate health monitoring Prostate International |
| title | Looking to the metabolic landscapes for prostate health monitoring |
| title_full | Looking to the metabolic landscapes for prostate health monitoring |
| title_fullStr | Looking to the metabolic landscapes for prostate health monitoring |
| title_full_unstemmed | Looking to the metabolic landscapes for prostate health monitoring |
| title_short | Looking to the metabolic landscapes for prostate health monitoring |
| title_sort | looking to the metabolic landscapes for prostate health monitoring |
| url | http://www.sciencedirect.com/science/article/pii/S2287888217300442 |
| work_keys_str_mv | AT wunjaekim lookingtothemetaboliclandscapesforprostatehealthmonitoring AT jayoungkim lookingtothemetaboliclandscapesforprostatehealthmonitoring |