Cardiac Nuclear Imaging Findings in Atypical Variants of Takotsubo Cardiomyopathy
Background: In addition to the typical form resembling the classical Japanese octopus trap, atypical variants of Takotsubo cardiomyopathy (TTC) sparing the left ventricular apex have emerged over the years. The aim of this systematic review is to provide a comprehensive overview of the cardiac nucle...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-01-01
|
| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3417/14/2/487 |
| _version_ | 1827369956387323904 |
|---|---|
| author | Maria Silvia De Feo Miriam Conte Viviana Frantellizzi Luca Filippi Laura Evangelista Maria Ricci Giuseppe De Vincentis |
| author_facet | Maria Silvia De Feo Miriam Conte Viviana Frantellizzi Luca Filippi Laura Evangelista Maria Ricci Giuseppe De Vincentis |
| author_sort | Maria Silvia De Feo |
| collection | DOAJ |
| description | Background: In addition to the typical form resembling the classical Japanese octopus trap, atypical variants of Takotsubo cardiomyopathy (TTC) sparing the left ventricular apex have emerged over the years. The aim of this systematic review is to provide a comprehensive overview of the cardiac nuclear imaging findings in atypical variants. Methods: This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The literature research was carried out online on the Pubmed, Scopus, Central (Cochrane Library), and Web Of Science databases. Results: A total of 14 articles were ultimately selected. Myocardial perfusion scintigraphy was performed in nine studies, followed by 123I-mIBG scintigraphy, 123I-BMIPP scintigraphy, and 18F-FDG PET. In seven cases, a single cardiac nuclear imaging technique was performed, while in the remaining five and two cases, two and three different imaging modalities were, respectively, used. The most common atypical variant of our selection was the midventricular form, followed by reverse/inverted/basal TTC, with only a single case reported of a focal pattern. Conclusions: As the reason why TTC variants occur is still not clear, a deeper understanding of the current knowledge could be the basis for providing more insights into this fascinating disorder and its uncommon manifestations. |
| first_indexed | 2024-03-08T10:00:15Z |
| format | Article |
| id | doaj.art-d3abd405afac477c832a801b2b0dc8f8 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-08T10:00:15Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-d3abd405afac477c832a801b2b0dc8f82024-01-29T13:41:54ZengMDPI AGApplied Sciences2076-34172024-01-0114248710.3390/app14020487Cardiac Nuclear Imaging Findings in Atypical Variants of Takotsubo CardiomyopathyMaria Silvia De Feo0Miriam Conte1Viviana Frantellizzi2Luca Filippi3Laura Evangelista4Maria Ricci5Giuseppe De Vincentis6Department of Radiological Sciences, Oncology and Anatomo Pathology, Sapienza, University of Rome, 00161 Rome, ItalyDepartment of Radiological Sciences, Oncology and Anatomo Pathology, Sapienza, University of Rome, 00161 Rome, ItalyDepartment of Radiological Sciences, Oncology and Anatomo Pathology, Sapienza, University of Rome, 00161 Rome, ItalyNuclear Medicine Unit, Department of Oncohaematology, Fondazione PTV Policlinico Tor Vergata University Hospital, 00133 Roma, ItalyDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, ItalyNuclear Medicine Unit, Cardarelli Hospital, 86100 Campobasso, ItalyDepartment of Radiological Sciences, Oncology and Anatomo Pathology, Sapienza, University of Rome, 00161 Rome, ItalyBackground: In addition to the typical form resembling the classical Japanese octopus trap, atypical variants of Takotsubo cardiomyopathy (TTC) sparing the left ventricular apex have emerged over the years. The aim of this systematic review is to provide a comprehensive overview of the cardiac nuclear imaging findings in atypical variants. Methods: This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The literature research was carried out online on the Pubmed, Scopus, Central (Cochrane Library), and Web Of Science databases. Results: A total of 14 articles were ultimately selected. Myocardial perfusion scintigraphy was performed in nine studies, followed by 123I-mIBG scintigraphy, 123I-BMIPP scintigraphy, and 18F-FDG PET. In seven cases, a single cardiac nuclear imaging technique was performed, while in the remaining five and two cases, two and three different imaging modalities were, respectively, used. The most common atypical variant of our selection was the midventricular form, followed by reverse/inverted/basal TTC, with only a single case reported of a focal pattern. Conclusions: As the reason why TTC variants occur is still not clear, a deeper understanding of the current knowledge could be the basis for providing more insights into this fascinating disorder and its uncommon manifestations.https://www.mdpi.com/2076-3417/14/2/487takotsubo123I-mIBG123I-BMIPP18F-FDG PETcardiac nuclear imagingTTC |
| spellingShingle | Maria Silvia De Feo Miriam Conte Viviana Frantellizzi Luca Filippi Laura Evangelista Maria Ricci Giuseppe De Vincentis Cardiac Nuclear Imaging Findings in Atypical Variants of Takotsubo Cardiomyopathy Applied Sciences takotsubo 123I-mIBG 123I-BMIPP 18F-FDG PET cardiac nuclear imaging TTC |
| title | Cardiac Nuclear Imaging Findings in Atypical Variants of Takotsubo Cardiomyopathy |
| title_full | Cardiac Nuclear Imaging Findings in Atypical Variants of Takotsubo Cardiomyopathy |
| title_fullStr | Cardiac Nuclear Imaging Findings in Atypical Variants of Takotsubo Cardiomyopathy |
| title_full_unstemmed | Cardiac Nuclear Imaging Findings in Atypical Variants of Takotsubo Cardiomyopathy |
| title_short | Cardiac Nuclear Imaging Findings in Atypical Variants of Takotsubo Cardiomyopathy |
| title_sort | cardiac nuclear imaging findings in atypical variants of takotsubo cardiomyopathy |
| topic | takotsubo 123I-mIBG 123I-BMIPP 18F-FDG PET cardiac nuclear imaging TTC |
| url | https://www.mdpi.com/2076-3417/14/2/487 |
| work_keys_str_mv | AT mariasilviadefeo cardiacnuclearimagingfindingsinatypicalvariantsoftakotsubocardiomyopathy AT miriamconte cardiacnuclearimagingfindingsinatypicalvariantsoftakotsubocardiomyopathy AT vivianafrantellizzi cardiacnuclearimagingfindingsinatypicalvariantsoftakotsubocardiomyopathy AT lucafilippi cardiacnuclearimagingfindingsinatypicalvariantsoftakotsubocardiomyopathy AT lauraevangelista cardiacnuclearimagingfindingsinatypicalvariantsoftakotsubocardiomyopathy AT mariaricci cardiacnuclearimagingfindingsinatypicalvariantsoftakotsubocardiomyopathy AT giuseppedevincentis cardiacnuclearimagingfindingsinatypicalvariantsoftakotsubocardiomyopathy |