SIRT4-Catalyzed Deacetylation of Axin1 Modulates the Wnt/β-Catenin Signaling Pathway

SIRT4-Catalyzed Deacetylation of Axin1 Modulates the Wnt/β-Catenin Signaling Pathway

Axin1 is a fundamental scaffolding protein of the destruction complex in the canonical Wnt signaling pathway, which plays a critical role in various biological processes. However, how Axin1 is regulated in the activation of the canonical Wnt signaling pathway remains elusive. Here, we report that Ax...

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Bibliographic Details
Main Authors: Yuting Wang, Jicheng Yue, Mingzhe Xiao, Xiaomei Lu, Yuen Eugene Chin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
Axin1
SIRT4
deacetylation
β-catenin
Wnt signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.872444/full

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