IRF-5 Expression in Myeloid Cells Is Required for Splenomegaly in L. donovani Infected Mice

IRF-5 Expression in Myeloid Cells Is Required for Splenomegaly in L. donovani Infected Mice

Persistent Leishmania donovani infection is characterized by chronic inflammation, immune suppression, and splenomegaly. We have previously reported that the transcription factor interferon regulatory factor 5 (IRF-5) is largely responsible for inducing the inflammatory response and maintaining prot...

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Bibliographic Details
Main Authors: Linh Thuy Mai, Mélina Smans, Sasha Silva-Barrios, Aymeric Fabié, Simona Stäger
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
Leishmania
IRF5
myeloid cells
splenomegaly
Th1
LysM-cre
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03071/full

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