The Role of Post-Translational Modifications in Regulation of NLRP3 Inflammasome Activation
Pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) induce NLRP3 inflammasome activation, and subsequent formation of active caspase-1 as well as the maturation of interleukin-1β (IL-1β) and gasdermin D (GSDMD), mediating the occurrence of pyroptosis and i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/7/6126 |
| _version_ | 1797607914004807680 |
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| author | Jing Xia Songhong Jiang Shiqi Dong Yonghong Liao Yang Zhou |
| author_facet | Jing Xia Songhong Jiang Shiqi Dong Yonghong Liao Yang Zhou |
| author_sort | Jing Xia |
| collection | DOAJ |
| description | Pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) induce NLRP3 inflammasome activation, and subsequent formation of active caspase-1 as well as the maturation of interleukin-1β (IL-1β) and gasdermin D (GSDMD), mediating the occurrence of pyroptosis and inflammation. Aberrant NLRP3 inflammasome activation causes a variety of diseases. Therefore, the NLRP3 inflammasome pathway is a target for prevention and treatment of relative diseases. Recent studies have suggested that NLRP3 inflammasome activity is closely associated with its post-translational modifications (PTMs). This review focuses on PTMs of the components of the NLRP3 inflammasome and the resultant effects on regulation of its activity to provide references for the exploration of the mechanisms by which the NLRP3 inflammasome is activated and controlled. |
| first_indexed | 2024-03-11T05:36:16Z |
| format | Article |
| id | doaj.art-d3acb683ba784a148a8606df253ddc3e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T05:36:16Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d3acb683ba784a148a8606df253ddc3e2023-11-17T16:46:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01247612610.3390/ijms24076126The Role of Post-Translational Modifications in Regulation of NLRP3 Inflammasome ActivationJing Xia0Songhong Jiang1Shiqi Dong2Yonghong Liao3Yang Zhou4College of Veterinary Medicine, Southwest University, Chongqing 402460, ChinaCollege of Veterinary Medicine, Southwest University, Chongqing 402460, ChinaCollege of Veterinary Medicine, Southwest University, Chongqing 402460, ChinaCollege of Veterinary Medicine, Southwest University, Chongqing 402460, ChinaCollege of Veterinary Medicine, Southwest University, Chongqing 402460, ChinaPathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) induce NLRP3 inflammasome activation, and subsequent formation of active caspase-1 as well as the maturation of interleukin-1β (IL-1β) and gasdermin D (GSDMD), mediating the occurrence of pyroptosis and inflammation. Aberrant NLRP3 inflammasome activation causes a variety of diseases. Therefore, the NLRP3 inflammasome pathway is a target for prevention and treatment of relative diseases. Recent studies have suggested that NLRP3 inflammasome activity is closely associated with its post-translational modifications (PTMs). This review focuses on PTMs of the components of the NLRP3 inflammasome and the resultant effects on regulation of its activity to provide references for the exploration of the mechanisms by which the NLRP3 inflammasome is activated and controlled.https://www.mdpi.com/1422-0067/24/7/6126inflammasomeNLRP3post-translational modification |
| spellingShingle | Jing Xia Songhong Jiang Shiqi Dong Yonghong Liao Yang Zhou The Role of Post-Translational Modifications in Regulation of NLRP3 Inflammasome Activation International Journal of Molecular Sciences inflammasome NLRP3 post-translational modification |
| title | The Role of Post-Translational Modifications in Regulation of NLRP3 Inflammasome Activation |
| title_full | The Role of Post-Translational Modifications in Regulation of NLRP3 Inflammasome Activation |
| title_fullStr | The Role of Post-Translational Modifications in Regulation of NLRP3 Inflammasome Activation |
| title_full_unstemmed | The Role of Post-Translational Modifications in Regulation of NLRP3 Inflammasome Activation |
| title_short | The Role of Post-Translational Modifications in Regulation of NLRP3 Inflammasome Activation |
| title_sort | role of post translational modifications in regulation of nlrp3 inflammasome activation |
| topic | inflammasome NLRP3 post-translational modification |
| url | https://www.mdpi.com/1422-0067/24/7/6126 |
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