Targeting host-specific metabolic pathways—opportunities and challenges for anti-infective therapy
Microorganisms can takeover critical metabolic pathways in host cells to fuel their replication. This interaction provides an opportunity to target host metabolic pathways, in addition to the pathogen-specific ones, in the development of antimicrobials. Host-directed therapy (HDT) is an emerging str...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2024.1338567/full |
| _version_ | 1797300180042645504 |
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| author | Monika I. Konaklieva Balbina J. Plotkin |
| author_facet | Monika I. Konaklieva Balbina J. Plotkin |
| author_sort | Monika I. Konaklieva |
| collection | DOAJ |
| description | Microorganisms can takeover critical metabolic pathways in host cells to fuel their replication. This interaction provides an opportunity to target host metabolic pathways, in addition to the pathogen-specific ones, in the development of antimicrobials. Host-directed therapy (HDT) is an emerging strategy of anti-infective therapy, which targets host cell metabolism utilized by facultative and obligate intracellular pathogens for entry, replication, egress or persistence of infected host cells. This review provides an overview of the host lipid metabolism and links it to the challenges in the development of HDTs for viral and bacterial infections, where pathogens are using important for the host lipid enzymes, or producing their own analogous of lecithin-cholesterol acyltransferase (LCAT) and lipoprotein lipase (LPL) thus interfering with the human host’s lipid metabolism. |
| first_indexed | 2024-03-07T23:03:33Z |
| format | Article |
| id | doaj.art-d3ae586094b14883af3b6e94cbae3ea7 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-03-07T23:03:33Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-d3ae586094b14883af3b6e94cbae3ea72024-02-22T09:30:39ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2024-02-011110.3389/fmolb.2024.13385671338567Targeting host-specific metabolic pathways—opportunities and challenges for anti-infective therapyMonika I. Konaklieva0Balbina J. Plotkin1Department of Chemistry, American University, Washington, DC, United StatesDepartment of Microbiology and Immunology, Midwestern University, Downers Grove, IL, United StatesMicroorganisms can takeover critical metabolic pathways in host cells to fuel their replication. This interaction provides an opportunity to target host metabolic pathways, in addition to the pathogen-specific ones, in the development of antimicrobials. Host-directed therapy (HDT) is an emerging strategy of anti-infective therapy, which targets host cell metabolism utilized by facultative and obligate intracellular pathogens for entry, replication, egress or persistence of infected host cells. This review provides an overview of the host lipid metabolism and links it to the challenges in the development of HDTs for viral and bacterial infections, where pathogens are using important for the host lipid enzymes, or producing their own analogous of lecithin-cholesterol acyltransferase (LCAT) and lipoprotein lipase (LPL) thus interfering with the human host’s lipid metabolism.https://www.frontiersin.org/articles/10.3389/fmolb.2024.1338567/fulllipid enzymesLCATLPLhost-directed therapyintracellular pathogensanti-infectives |
| spellingShingle | Monika I. Konaklieva Balbina J. Plotkin Targeting host-specific metabolic pathways—opportunities and challenges for anti-infective therapy Frontiers in Molecular Biosciences lipid enzymes LCAT LPL host-directed therapy intracellular pathogens anti-infectives |
| title | Targeting host-specific metabolic pathways—opportunities and challenges for anti-infective therapy |
| title_full | Targeting host-specific metabolic pathways—opportunities and challenges for anti-infective therapy |
| title_fullStr | Targeting host-specific metabolic pathways—opportunities and challenges for anti-infective therapy |
| title_full_unstemmed | Targeting host-specific metabolic pathways—opportunities and challenges for anti-infective therapy |
| title_short | Targeting host-specific metabolic pathways—opportunities and challenges for anti-infective therapy |
| title_sort | targeting host specific metabolic pathways opportunities and challenges for anti infective therapy |
| topic | lipid enzymes LCAT LPL host-directed therapy intracellular pathogens anti-infectives |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2024.1338567/full |
| work_keys_str_mv | AT monikaikonaklieva targetinghostspecificmetabolicpathwaysopportunitiesandchallengesforantiinfectivetherapy AT balbinajplotkin targetinghostspecificmetabolicpathwaysopportunitiesandchallengesforantiinfectivetherapy |