A Case of Early-Stage Gallbladder Cancer, Positive for ALDH1A1, Which Arose from Adenomyomatosis of the Gallbladder
Adenomyomatosis (ADM) of the gallbladder is a condition characterized by the proliferation of Rokitansky–Aschoff sinus (RAS), in which the epithelium of the gallbladder extends into the muscular layer, causing a thickening of the gallbladder wall. Although ADM is generally considered not to be a pre...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/11/2721 |
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| author | Yuhei Iwasa Keisuke Iwata Mitsuru Okuno Akihiko Sugiyama Yoichi Nishigaki Yosuke Ohashi Takuji Tanaka Takuji Iwashita Masahito Shimizu Eiichi Tomita |
| author_facet | Yuhei Iwasa Keisuke Iwata Mitsuru Okuno Akihiko Sugiyama Yoichi Nishigaki Yosuke Ohashi Takuji Tanaka Takuji Iwashita Masahito Shimizu Eiichi Tomita |
| author_sort | Yuhei Iwasa |
| collection | DOAJ |
| description | Adenomyomatosis (ADM) of the gallbladder is a condition characterized by the proliferation of Rokitansky–Aschoff sinus (RAS), in which the epithelium of the gallbladder extends into the muscular layer, causing a thickening of the gallbladder wall. Although ADM is generally considered not to be a precancerous lesion of gallbladder cancer, there are some reports of cases of gallbladder cancer from ADM. Therefore, the relationship between ADM and gallbladder cancer remains controversial. We herein report a case of early-stage gallbladder cancer, BilIN3 (high grade), arising from ADM that was positive for ALDH1A1, an important marker of stem cells and cancer stem cells. |
| first_indexed | 2024-03-09T19:09:45Z |
| format | Article |
| id | doaj.art-d3af28add2b1474a82cb61255b3f823c |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T19:09:45Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-d3af28add2b1474a82cb61255b3f823c2023-11-24T04:19:51ZengMDPI AGDiagnostics2075-44182022-11-011211272110.3390/diagnostics12112721A Case of Early-Stage Gallbladder Cancer, Positive for ALDH1A1, Which Arose from Adenomyomatosis of the GallbladderYuhei Iwasa0Keisuke Iwata1Mitsuru Okuno2Akihiko Sugiyama3Yoichi Nishigaki4Yosuke Ohashi5Takuji Tanaka6Takuji Iwashita7Masahito Shimizu8Eiichi Tomita9Department of Gastroenterology, Gifu Municipal Hospital, 7-1 Kashima-cho, Gifu 500-8513, JapanDepartment of Gastroenterology, Gifu Municipal Hospital, 7-1 Kashima-cho, Gifu 500-8513, JapanDepartment of Gastroenterology, Gifu Municipal Hospital, 7-1 Kashima-cho, Gifu 500-8513, JapanDepartment of Gastroenterology, Gifu Municipal Hospital, 7-1 Kashima-cho, Gifu 500-8513, JapanDepartment of Gastroenterology, Gifu Municipal Hospital, 7-1 Kashima-cho, Gifu 500-8513, JapanDepartment of Gastroenterology, Gifu Municipal Hospital, 7-1 Kashima-cho, Gifu 500-8513, JapanDepartment of Diagnostic Pathology, Gifu Municipal Hospital, 7-1 Kashima-cho, Gifu 500-8513, JapanDepartment of Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, JapanDepartment of Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, JapanDepartment of Gastroenterology, Gifu Municipal Hospital, 7-1 Kashima-cho, Gifu 500-8513, JapanAdenomyomatosis (ADM) of the gallbladder is a condition characterized by the proliferation of Rokitansky–Aschoff sinus (RAS), in which the epithelium of the gallbladder extends into the muscular layer, causing a thickening of the gallbladder wall. Although ADM is generally considered not to be a precancerous lesion of gallbladder cancer, there are some reports of cases of gallbladder cancer from ADM. Therefore, the relationship between ADM and gallbladder cancer remains controversial. We herein report a case of early-stage gallbladder cancer, BilIN3 (high grade), arising from ADM that was positive for ALDH1A1, an important marker of stem cells and cancer stem cells.https://www.mdpi.com/2075-4418/12/11/2721adenomyomatosisRokitansky–Aschoff sinusBilIN3stem cell markerALDH1A1 |
| spellingShingle | Yuhei Iwasa Keisuke Iwata Mitsuru Okuno Akihiko Sugiyama Yoichi Nishigaki Yosuke Ohashi Takuji Tanaka Takuji Iwashita Masahito Shimizu Eiichi Tomita A Case of Early-Stage Gallbladder Cancer, Positive for ALDH1A1, Which Arose from Adenomyomatosis of the Gallbladder Diagnostics adenomyomatosis Rokitansky–Aschoff sinus BilIN3 stem cell marker ALDH1A1 |
| title | A Case of Early-Stage Gallbladder Cancer, Positive for ALDH1A1, Which Arose from Adenomyomatosis of the Gallbladder |
| title_full | A Case of Early-Stage Gallbladder Cancer, Positive for ALDH1A1, Which Arose from Adenomyomatosis of the Gallbladder |
| title_fullStr | A Case of Early-Stage Gallbladder Cancer, Positive for ALDH1A1, Which Arose from Adenomyomatosis of the Gallbladder |
| title_full_unstemmed | A Case of Early-Stage Gallbladder Cancer, Positive for ALDH1A1, Which Arose from Adenomyomatosis of the Gallbladder |
| title_short | A Case of Early-Stage Gallbladder Cancer, Positive for ALDH1A1, Which Arose from Adenomyomatosis of the Gallbladder |
| title_sort | case of early stage gallbladder cancer positive for aldh1a1 which arose from adenomyomatosis of the gallbladder |
| topic | adenomyomatosis Rokitansky–Aschoff sinus BilIN3 stem cell marker ALDH1A1 |
| url | https://www.mdpi.com/2075-4418/12/11/2721 |
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