Acute Effect of L-Citrulline Supplementation on Resistance Exercise Performance and Muscle Oxygenation in Recreationally Resistance Trained Men and Women
L-citrulline serves as a nitric oxide precursor with the potential to increase blood flow and improve resistance exercise performance, yet more research is needed to examine its ergogenic potential. To examine the effect of L-citrulline supplementation on resistance exercise performance, muscle oxyg...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Journal of Functional Morphology and Kinesiology |
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| Online Access: | https://www.mdpi.com/2411-5142/8/3/88 |
| _version_ | 1797579402050011136 |
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| author | Adam M. Gonzalez Yang Yang Gerald T. Mangine Anthony G. Pinzone Jamie J. Ghigiarelli Katie M. Sell |
| author_facet | Adam M. Gonzalez Yang Yang Gerald T. Mangine Anthony G. Pinzone Jamie J. Ghigiarelli Katie M. Sell |
| author_sort | Adam M. Gonzalez |
| collection | DOAJ |
| description | L-citrulline serves as a nitric oxide precursor with the potential to increase blood flow and improve resistance exercise performance, yet more research is needed to examine its ergogenic potential. To examine the effect of L-citrulline supplementation on resistance exercise performance, muscle oxygenation, and the subjective perception of effort, energy, focus, fatigue, and muscle pump, eighteen resistance-trained men (<i>n</i> = 11) and women (<i>n</i> = 7) (21.4 ± 1.8 years; 172.3 ± 7.5 cm; 76.9 ± 10.8 kg) were randomly assigned for supplementation with 8 g of L-citrulline (CIT) or a placebo (PL) in a cross-over fashion one hour prior to testing. Participants completed an isometric mid-thigh pull test (IMTP), a ballistic bench press protocol [two sets of two repetitions at 75% 1-repetition maximum (1 RM) with maximum ballistic intent], and a strength-endurance bench press protocol [five repetition-maximum sets at 75% 1RM]. Barbell velocity and power were measured via a linear position transducer during the ballistic protocol, while the repetitions completed, volume load and muscle oxygenation were quantified during the strength-endurance protocol. Subjective measures were assessed at the baseline and immediately pre- and post-exercise. Repeated measures of the analysis of variance and Bayesian equivalents revealed no significant interactions, providing evidence favoring the null hypothesis (BF10 < 1) for IMTP (PL 497.5 ± 133.6 vs. CIT 492.5 ± 129.4 N), barbell velocity, and power, and repetitions completed (PL 36.7 ± 7.2 vs. CIT 36.9 ± 8.1 repetitions). There were also no significant interactions for muscle oxygenation parameters or subjective measures except perceived fatigue. Women reported greater fatigue across all time points compared to men (~1.88 au, <i>p</i> = 0.045, BF10 = 0.2). The results indicate that a single 8 g dose of L-citrulline did not enhance isometric force production, muscle endurance, or muscle oxygenation parameters during the protocol implemented in this study. |
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| institution | Directory Open Access Journal |
| issn | 2411-5142 |
| language | English |
| last_indexed | 2024-03-10T22:36:36Z |
| publishDate | 2023-06-01 |
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| spelling | doaj.art-d3af8b30cb4d47198273b43d0dffd3ad2023-11-19T11:23:46ZengMDPI AGJournal of Functional Morphology and Kinesiology2411-51422023-06-01838810.3390/jfmk8030088Acute Effect of L-Citrulline Supplementation on Resistance Exercise Performance and Muscle Oxygenation in Recreationally Resistance Trained Men and WomenAdam M. Gonzalez0Yang Yang1Gerald T. Mangine2Anthony G. Pinzone3Jamie J. Ghigiarelli4Katie M. Sell5Department of Allied Health and Kinesiology, Hofstra University, Hempstead, NY 11549, USADepartment of Allied Health and Kinesiology, Hofstra University, Hempstead, NY 11549, USADepartment of Exercise Science and Sport Management, Kennesaw State University, Kennesaw, GA 30144, USAProgram in Exercise Science and Exercise Physiology, Kent State University, Kent, OH 44242, USADepartment of Allied Health and Kinesiology, Hofstra University, Hempstead, NY 11549, USADepartment of Allied Health and Kinesiology, Hofstra University, Hempstead, NY 11549, USAL-citrulline serves as a nitric oxide precursor with the potential to increase blood flow and improve resistance exercise performance, yet more research is needed to examine its ergogenic potential. To examine the effect of L-citrulline supplementation on resistance exercise performance, muscle oxygenation, and the subjective perception of effort, energy, focus, fatigue, and muscle pump, eighteen resistance-trained men (<i>n</i> = 11) and women (<i>n</i> = 7) (21.4 ± 1.8 years; 172.3 ± 7.5 cm; 76.9 ± 10.8 kg) were randomly assigned for supplementation with 8 g of L-citrulline (CIT) or a placebo (PL) in a cross-over fashion one hour prior to testing. Participants completed an isometric mid-thigh pull test (IMTP), a ballistic bench press protocol [two sets of two repetitions at 75% 1-repetition maximum (1 RM) with maximum ballistic intent], and a strength-endurance bench press protocol [five repetition-maximum sets at 75% 1RM]. Barbell velocity and power were measured via a linear position transducer during the ballistic protocol, while the repetitions completed, volume load and muscle oxygenation were quantified during the strength-endurance protocol. Subjective measures were assessed at the baseline and immediately pre- and post-exercise. Repeated measures of the analysis of variance and Bayesian equivalents revealed no significant interactions, providing evidence favoring the null hypothesis (BF10 < 1) for IMTP (PL 497.5 ± 133.6 vs. CIT 492.5 ± 129.4 N), barbell velocity, and power, and repetitions completed (PL 36.7 ± 7.2 vs. CIT 36.9 ± 8.1 repetitions). There were also no significant interactions for muscle oxygenation parameters or subjective measures except perceived fatigue. Women reported greater fatigue across all time points compared to men (~1.88 au, <i>p</i> = 0.045, BF10 = 0.2). The results indicate that a single 8 g dose of L-citrulline did not enhance isometric force production, muscle endurance, or muscle oxygenation parameters during the protocol implemented in this study.https://www.mdpi.com/2411-5142/8/3/88nitric oxideargininecitrulline malateergogenic aidresistance training |
| spellingShingle | Adam M. Gonzalez Yang Yang Gerald T. Mangine Anthony G. Pinzone Jamie J. Ghigiarelli Katie M. Sell Acute Effect of L-Citrulline Supplementation on Resistance Exercise Performance and Muscle Oxygenation in Recreationally Resistance Trained Men and Women Journal of Functional Morphology and Kinesiology nitric oxide arginine citrulline malate ergogenic aid resistance training |
| title | Acute Effect of L-Citrulline Supplementation on Resistance Exercise Performance and Muscle Oxygenation in Recreationally Resistance Trained Men and Women |
| title_full | Acute Effect of L-Citrulline Supplementation on Resistance Exercise Performance and Muscle Oxygenation in Recreationally Resistance Trained Men and Women |
| title_fullStr | Acute Effect of L-Citrulline Supplementation on Resistance Exercise Performance and Muscle Oxygenation in Recreationally Resistance Trained Men and Women |
| title_full_unstemmed | Acute Effect of L-Citrulline Supplementation on Resistance Exercise Performance and Muscle Oxygenation in Recreationally Resistance Trained Men and Women |
| title_short | Acute Effect of L-Citrulline Supplementation on Resistance Exercise Performance and Muscle Oxygenation in Recreationally Resistance Trained Men and Women |
| title_sort | acute effect of l citrulline supplementation on resistance exercise performance and muscle oxygenation in recreationally resistance trained men and women |
| topic | nitric oxide arginine citrulline malate ergogenic aid resistance training |
| url | https://www.mdpi.com/2411-5142/8/3/88 |
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