MODELING CHRONIC TRAUMATIC ENCEPHALOPATHY: THE WAY FORWARD FOR FUTURE DISCOVERY
Despite the extensive media coverage associated with the diagnosis of chronic traumatic encephalopathy (CTE), our fundamental understanding of the disease pathophysiology remains in its infancy. Only recently have scientific laboratories and personnel begun to explore CTE pathophysiology through th...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-10-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00223/full |
| _version_ | 1811217736692400128 |
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| author | Ryan C. Turner Brandon Peter Lucke-Wold Aric Flint Logsdon Matthew James Robson John eLee Julian eBailes Matthew eDashnaw Jason eHuber Anthony ePetraglia Charles eRosen |
| author_facet | Ryan C. Turner Brandon Peter Lucke-Wold Aric Flint Logsdon Matthew James Robson John eLee Julian eBailes Matthew eDashnaw Jason eHuber Anthony ePetraglia Charles eRosen |
| author_sort | Ryan C. Turner |
| collection | DOAJ |
| description | Despite the extensive media coverage associated with the diagnosis of chronic traumatic encephalopathy (CTE), our fundamental understanding of the disease pathophysiology remains in its infancy. Only recently have scientific laboratories and personnel begun to explore CTE pathophysiology through the use of preclinical models of neurotrauma. Some studies have shown the ability to recapitulate some aspects of CTE in rodent models, through the use of various neuropathologic, biochemical, and/or behavioral assays. Many questions related to CTE development however remain unanswered. These include the role of impact severity, the time interval between impacts, the age at which impacts occur, and the total number of impacts sustained. Other important variables such as the location of impacts, character of impacts, and effect of environment/lifestyle and genetics also warrant further study. In this work we attempt to address some of these questions by exploring work previously completed using single and repetitive injury paradigms. Despite some models producing some deficits similar to CTE symptoms, it is clear that further studies are required to understand the development of neuropathological and neurobehavioral features consistent with CTE-like features in rodents. Specifically, acute and chronic studies are needed that characterize the development of tau-based pathology. |
| first_indexed | 2024-04-12T06:59:39Z |
| format | Article |
| id | doaj.art-d3b024e9921f4eaeae3eddeb07c5aac4 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T06:59:39Z |
| publishDate | 2015-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-d3b024e9921f4eaeae3eddeb07c5aac42022-12-22T03:43:03ZengFrontiers Media S.A.Frontiers in Neurology1664-22952015-10-01610.3389/fneur.2015.00223159982MODELING CHRONIC TRAUMATIC ENCEPHALOPATHY: THE WAY FORWARD FOR FUTURE DISCOVERYRyan C. Turner0Brandon Peter Lucke-Wold1Aric Flint Logsdon2Matthew James Robson3John eLee4Julian eBailes5Matthew eDashnaw6Jason eHuber7Anthony ePetraglia8Charles eRosen9West Virginia UniversityWest Virginia UniversityWest Virginia UniversityVanderbilt UniversityNorthshore University Health SystemNorthshore University Health SystemUniversity of Rochester Medical CenterWest Virginia UniversityUnity HospitalWest Virginia UniversityDespite the extensive media coverage associated with the diagnosis of chronic traumatic encephalopathy (CTE), our fundamental understanding of the disease pathophysiology remains in its infancy. Only recently have scientific laboratories and personnel begun to explore CTE pathophysiology through the use of preclinical models of neurotrauma. Some studies have shown the ability to recapitulate some aspects of CTE in rodent models, through the use of various neuropathologic, biochemical, and/or behavioral assays. Many questions related to CTE development however remain unanswered. These include the role of impact severity, the time interval between impacts, the age at which impacts occur, and the total number of impacts sustained. Other important variables such as the location of impacts, character of impacts, and effect of environment/lifestyle and genetics also warrant further study. In this work we attempt to address some of these questions by exploring work previously completed using single and repetitive injury paradigms. Despite some models producing some deficits similar to CTE symptoms, it is clear that further studies are required to understand the development of neuropathological and neurobehavioral features consistent with CTE-like features in rodents. Specifically, acute and chronic studies are needed that characterize the development of tau-based pathology.http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00223/fullneurodegenerationneurotraumapreclinical modelschronic traumatic encephalopathyHyperphosphorylated tau |
| spellingShingle | Ryan C. Turner Brandon Peter Lucke-Wold Aric Flint Logsdon Matthew James Robson John eLee Julian eBailes Matthew eDashnaw Jason eHuber Anthony ePetraglia Charles eRosen MODELING CHRONIC TRAUMATIC ENCEPHALOPATHY: THE WAY FORWARD FOR FUTURE DISCOVERY Frontiers in Neurology neurodegeneration neurotrauma preclinical models chronic traumatic encephalopathy Hyperphosphorylated tau |
| title | MODELING CHRONIC TRAUMATIC ENCEPHALOPATHY: THE WAY FORWARD FOR FUTURE DISCOVERY |
| title_full | MODELING CHRONIC TRAUMATIC ENCEPHALOPATHY: THE WAY FORWARD FOR FUTURE DISCOVERY |
| title_fullStr | MODELING CHRONIC TRAUMATIC ENCEPHALOPATHY: THE WAY FORWARD FOR FUTURE DISCOVERY |
| title_full_unstemmed | MODELING CHRONIC TRAUMATIC ENCEPHALOPATHY: THE WAY FORWARD FOR FUTURE DISCOVERY |
| title_short | MODELING CHRONIC TRAUMATIC ENCEPHALOPATHY: THE WAY FORWARD FOR FUTURE DISCOVERY |
| title_sort | modeling chronic traumatic encephalopathy the way forward for future discovery |
| topic | neurodegeneration neurotrauma preclinical models chronic traumatic encephalopathy Hyperphosphorylated tau |
| url | http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00223/full |
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