Directed Differentiation of Mobilized Hematopoietic Stem and Progenitor Cells into Functional NK Cells with Enhanced Antitumor Activity

Directed Differentiation of Mobilized Hematopoietic Stem and Progenitor Cells into Functional NK Cells with Enhanced Antitumor Activity

Obtaining sufficient numbers of functional natural killer (NK) cells is crucial for the success of NK-cell-based adoptive immunotherapies. While expansion from peripheral blood (PB) is the current method of choice, ex vivo generation of NK cells from hematopoietic stem and progenitor cells (HSCs) ma...

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Bibliographic Details
Main Authors: Pranav Oberoi, Kathrina Kamenjarin, Jose Francisco Villena Ossa, Barbara Uherek, Halvard Bönig, Winfried S. Wels
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
natural killer cells
hematopoietic stem and progenitor cells
feeder cells
natural cytotoxicity
adoptive cancer immunotherapy
Online Access:https://www.mdpi.com/2073-4409/9/4/811

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