Evaluating the effects of circulating inflammatory proteins as drivers and therapeutic targets for severe COVID-19

Evaluating the effects of circulating inflammatory proteins as drivers and therapeutic targets for severe COVID-19

ObjectiveThe relationships between circulating inflammatory proteins and COVID-19 have been observed in previous cohorts. However, it is not unclear which circulating inflammatory proteins may boost the risk of or protect against COVID-19.MethodsWe performed Mendelian randomization (MR) analysis usi...

Full description

Bibliographic Details
Main Authors:	Ancha Baranova, Jing Luo, Li Fu, Guanqun Yao, Fuquan Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-02-01
Series:	Frontiers in Immunology
Subjects:	circulating inflammatory protein Mendelian randomization COVID-19 GWAS LIFR
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1352583/full

Similar Items

Causal influences of osteoarthritis on COVID-19: a Mendelian randomization study
by: Li Fu, et al.
Published: (2023-10-01)

Shared Genetic Liability and Causal Associations Between Major Depressive Disorder and Cardiovascular Diseases
by: Fuquan Zhang, et al.
Published: (2021-11-01)

Causal Association and Shared Genetics Between Asthma and COVID-19
by: Ancha Baranova, et al.
Published: (2022-03-01)

Unraveling Risk Genes of COVID-19 by Multi-Omics Integrative Analyses
by: Ancha Baranova, et al.
Published: (2021-09-01)

Causal associations of tea intake with COVID-19 infection and severity
by: Ancha Baranova, et al.
Published: (2023-01-01)

Shared Genetic Liability Between Major Depressive Disorder and Atopic Diseases
by: Hongbao Cao, et al.
Published: (2021-09-01)

Circulating cytokines and vascular dementia: A bi-directional Mendelian randomization study
by: Yuge Xia, et al.
Published: (2024-05-01)

Causal associations between COVID-19 and childhood mental disorders
by: Fei Chen, et al.
Published: (2023-12-01)

Shared genetic liability between major depressive disorder and osteoarthritis
by: Fuquan Zhang, et al.
Published: (2022-01-01)

Associations of inflammatory cytokines with inflammatory bowel disease: a Mendelian randomization study
by: Zhaoxiang Song, et al.
Published: (2024-01-01)

Circulating VEGF and inflammatory bowel disease: a bidirectional mendelian randomization
by: Haishan Lin, et al.
Published: (2024-04-01)

Circulating inflammatory cytokines and risk of idiopathic pulmonary fibrosis: a Mendelian randomization study
by: Qinyao Jia, et al.
Published: (2023-10-01)

Causal relationship between inflammatory cytokines and autoimmune thyroid disease: a bidirectional two-sample Mendelian randomization analysis
by: Zhiwei Yao, et al.
Published: (2024-03-01)

Genetic association of circulating C-reactive protein levels with idiopathic pulmonary fibrosis: a two-sample Mendelian randomization study
by: Kun Zhang, et al.
Published: (2023-01-01)

Targeting LIF/LIFR signaling in cancer
by: Suryavathi Viswanadhapalli, et al.
Published: (2022-07-01)

Levels of 91 circulating inflammatory proteins and risk of lumbar spine and pelvic fractures and peripheral ligament injuries: a two-sample mendelian randomization study
by: Huiyu Huang, et al.
Published: (2024-03-01)

Association between circulating vitamin E and ten common cancers: evidence from large-scale Mendelian randomization analysis and a longitudinal cohort study
by: Junyi Xin, et al.
Published: (2022-05-01)

BDNF Gene's Role in Schizophrenia: From Risk Allele to Methylation Implications
by: Xiaoqian Fu, et al.
Published: (2020-12-01)

Two-sample Mendelian randomization analysis evaluates causal associations between inflammatory bowel disease and osteoporosis
by: Zhujiang Dai, et al.
Published: (2023-05-01)

Cell-Free Circulating Nucleic Acids as Early Biomarkers for NAFLD and NAFLD-Associated Disorders
by: Andrey Turchinovich, et al.
Published: (2018-09-01)

Circulating vascular endothelial growth factor and cancer risk: A bidirectional mendelian randomization
by: Hong Wu, et al.
Published: (2022-09-01)

Genetically predicted circulating levels of cytokines and the risk of depression: a bidirectional Mendelian-randomization study
by: Meiti Wang, et al.
Published: (2023-08-01)

Causal relationships between circulating inflammatory factors and IgA vasculitis: a bidirectional Mendelian randomization study
by: Jiading Qin, et al.
Published: (2023-09-01)

Exploring causal correlations between inflammatory cytokines and ankylosing spondylitis: a bidirectional mendelian-randomization study
by: Peng Fang, et al.
Published: (2023-11-01)

Two-sample Mendelian randomization analysis of 91 circulating inflammatory protein levels and amyotrophic lateral sclerosis
by: Chenxu Xiao, et al.
Published: (2024-03-01)

Exploring the influences of education, intelligence and income on mental disorders
by: Fuquan Zhang, et al.
Published: (2024-02-01)

Causal associations between circulating inflammatory cytokines and blinding eye diseases: a bidirectional Mendelian randomization analysis
by: Menghao Teng, et al.
Published: (2024-01-01)

Diet-derived circulating antioxidants and risk of inflammatory bowel disease: a Mendelian randomization study and meta-analysis
by: Menglong Zou, et al.
Published: (2024-02-01)

Association between inflammatory bowel disease and interleukins, chemokines: a two-sample bidirectional mendelian randomization study
by: Guojiu Fang, et al.
Published: (2023-05-01)

Association of circulating inflammatory proteins with type 2 diabetes mellitus and its complications: a bidirectional Mendelian randomization study
by: Ying-Chao Liang, et al.
Published: (2024-03-01)

Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analysesResearch in context
by: Jie Chen, et al.
Published: (2023-03-01)

The MR-Base platform supports systematic causal inference across the human phenome
by: Gibran Hemani, et al.
Published: (2018-05-01)

Exploring the causal relationship between inflammatory cytokines and immunoinflammatory dermatoses: a Mendelian randomization study
by: Jiaxuan Li, et al.
Published: (2024-01-01)

Assessing the role of lipid-lowering therapy on multi-cancer prevention: A mendelian randomization study
by: Yu Min, et al.
Published: (2023-04-01)

Deregulatory miRNA-BDNF Network Inferred from Dynamic Expression Changes in Schizophrenia
by: Xiaoqian Fu, et al.
Published: (2022-01-01)

Diet-Derived Circulating Antioxidants and Risk of Digestive System Tumors: A Mendelian Randomization Study
by: Linlin Yin, et al.
Published: (2022-08-01)

Mendelian randomization to explore the direct or mediating associations between socioeconomic status and lung cancer
by: Hong Wu, et al.
Published: (2023-05-01)

Substance abuse and the risk of severe COVID-19: Mendelian randomization confirms the causal role of opioids but hints a negative causal effect for cannabinoids
by: M. Reza Jabalameli, et al.
Published: (2022-12-01)

Cynaropicrin Shows Antitumor Progression Potential in Colorectal Cancer Through Mediation of the LIFR/STATs Axis
by: Dandan Zheng, et al.
Published: (2021-01-01)

Genetically Predicted Circulating Concentrations of Micronutrients and COVID-19 Susceptibility and Severity: A Mendelian Randomization Study
by: Neil Daniel, et al.
Published: (2022-04-01)