Associations between Polyfluoroalkyl Substances Exposure and Breast Cancer: A Meta-Analysis
Polyfluoroalkyl substances (PFASs) are persistent pollutants that may cause breast cancer. However, associations between exposure to PFASs and the risk of breast cancer are controversial. We retrieved studies on the association between PFASs—perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFN...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Toxics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2305-6304/10/6/318 |
| _version_ | 1797481860950917120 |
|---|---|
| author | Haihong Jiang Huan Liu Ge Liu Jing Yu Nana Liu Yunqin Jin Yongyi Bi Hong Wang |
| author_facet | Haihong Jiang Huan Liu Ge Liu Jing Yu Nana Liu Yunqin Jin Yongyi Bi Hong Wang |
| author_sort | Haihong Jiang |
| collection | DOAJ |
| description | Polyfluoroalkyl substances (PFASs) are persistent pollutants that may cause breast cancer. However, associations between exposure to PFASs and the risk of breast cancer are controversial. We retrieved studies on the association between PFASs—perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorohexane sulfonic acid (PFHxS), and perfluorooctane sulfonic acid (PFOS)—and breast cancer risk in women from PubMed, Embase, and the Web of Science. The pooled odds ratios (ORs) or relative risks (RRs) and their 95% confidence intervals (CIs) were extracted or calculated from provided data. Moreover, subgroup and metaregression analyses were performed to distinguish the potential sources of heterogeneity between studies. Lastly, eight original studies were included in the meta-analysis. PFOA and PFHxS were positively correlated with breast cancer risk, and the pooled ORs (and 95% CIs) were 1.32 (1.19 and 1.46) and 1.79 (1.51 and 2.11), respectively. PFNA was negatively correlated with breast cancer risk and the pooled OR (and 95% CIs) was 0.76 (0.6 and 0.96), and PFOS was shown to have no correlation with breast cancer risk and the pooled OR (and 95% CIs) was 1.01 (0.87 and 1.17). All results were merged in a random-effects model with significant heterogeneities (<i>I</i><sup>2</sup> > 90%, <i>p</i> < 0.001). The results demonstrated that PFASs might be potential risk factors for breast cancer, and the compounds in low exposure levels could have a more harmful impact on human health. |
| first_indexed | 2024-03-09T22:20:35Z |
| format | Article |
| id | doaj.art-d3b4a4c7e7bd42a1893167a04870f71b |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-09T22:20:35Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-d3b4a4c7e7bd42a1893167a04870f71b2023-11-23T19:16:15ZengMDPI AGToxics2305-63042022-06-0110631810.3390/toxics10060318Associations between Polyfluoroalkyl Substances Exposure and Breast Cancer: A Meta-AnalysisHaihong Jiang0Huan Liu1Ge Liu2Jing Yu3Nana Liu4Yunqin Jin5Yongyi Bi6Hong Wang7School of Public Health, Wuhan University, Wuhan 430071, ChinaSchool of Public Health, Wuhan University, Wuhan 430071, ChinaSchool of Public Health, Wuhan University, Wuhan 430071, ChinaSchool of Public Health, Wuhan University, Wuhan 430071, ChinaSchool of Public Health, Wuhan University, Wuhan 430071, ChinaSchool of Public Health, Wuhan University, Wuhan 430071, ChinaSchool of Public Health, Wuhan University, Wuhan 430071, ChinaSchool of Public Health, Wuhan University, Wuhan 430071, ChinaPolyfluoroalkyl substances (PFASs) are persistent pollutants that may cause breast cancer. However, associations between exposure to PFASs and the risk of breast cancer are controversial. We retrieved studies on the association between PFASs—perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorohexane sulfonic acid (PFHxS), and perfluorooctane sulfonic acid (PFOS)—and breast cancer risk in women from PubMed, Embase, and the Web of Science. The pooled odds ratios (ORs) or relative risks (RRs) and their 95% confidence intervals (CIs) were extracted or calculated from provided data. Moreover, subgroup and metaregression analyses were performed to distinguish the potential sources of heterogeneity between studies. Lastly, eight original studies were included in the meta-analysis. PFOA and PFHxS were positively correlated with breast cancer risk, and the pooled ORs (and 95% CIs) were 1.32 (1.19 and 1.46) and 1.79 (1.51 and 2.11), respectively. PFNA was negatively correlated with breast cancer risk and the pooled OR (and 95% CIs) was 0.76 (0.6 and 0.96), and PFOS was shown to have no correlation with breast cancer risk and the pooled OR (and 95% CIs) was 1.01 (0.87 and 1.17). All results were merged in a random-effects model with significant heterogeneities (<i>I</i><sup>2</sup> > 90%, <i>p</i> < 0.001). The results demonstrated that PFASs might be potential risk factors for breast cancer, and the compounds in low exposure levels could have a more harmful impact on human health.https://www.mdpi.com/2305-6304/10/6/318polyfluoroalkyl substancebreast cancerpollutantmeta-analysis |
| spellingShingle | Haihong Jiang Huan Liu Ge Liu Jing Yu Nana Liu Yunqin Jin Yongyi Bi Hong Wang Associations between Polyfluoroalkyl Substances Exposure and Breast Cancer: A Meta-Analysis Toxics polyfluoroalkyl substance breast cancer pollutant meta-analysis |
| title | Associations between Polyfluoroalkyl Substances Exposure and Breast Cancer: A Meta-Analysis |
| title_full | Associations between Polyfluoroalkyl Substances Exposure and Breast Cancer: A Meta-Analysis |
| title_fullStr | Associations between Polyfluoroalkyl Substances Exposure and Breast Cancer: A Meta-Analysis |
| title_full_unstemmed | Associations between Polyfluoroalkyl Substances Exposure and Breast Cancer: A Meta-Analysis |
| title_short | Associations between Polyfluoroalkyl Substances Exposure and Breast Cancer: A Meta-Analysis |
| title_sort | associations between polyfluoroalkyl substances exposure and breast cancer a meta analysis |
| topic | polyfluoroalkyl substance breast cancer pollutant meta-analysis |
| url | https://www.mdpi.com/2305-6304/10/6/318 |
| work_keys_str_mv | AT haihongjiang associationsbetweenpolyfluoroalkylsubstancesexposureandbreastcancerametaanalysis AT huanliu associationsbetweenpolyfluoroalkylsubstancesexposureandbreastcancerametaanalysis AT geliu associationsbetweenpolyfluoroalkylsubstancesexposureandbreastcancerametaanalysis AT jingyu associationsbetweenpolyfluoroalkylsubstancesexposureandbreastcancerametaanalysis AT nanaliu associationsbetweenpolyfluoroalkylsubstancesexposureandbreastcancerametaanalysis AT yunqinjin associationsbetweenpolyfluoroalkylsubstancesexposureandbreastcancerametaanalysis AT yongyibi associationsbetweenpolyfluoroalkylsubstancesexposureandbreastcancerametaanalysis AT hongwang associationsbetweenpolyfluoroalkylsubstancesexposureandbreastcancerametaanalysis |