High-affinity peptide ligand LXY30 for targeting α3β1 integrin in non-small cell lung cancer

High-affinity peptide ligand LXY30 for targeting α3β1 integrin in non-small cell lung cancer

Abstract Background α3β1 integrin is a promising cancer biomarker and drug target. We previously identified a 9-amino-acid cyclic peptide LXY30 for detecting α3β1 integrin on the surface of live tumor cells. This study was undertaken to characterize LXY30 in the detection, cellular function, imaging...

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Bibliographic Details
Main Authors: Wenwu Xiao, Weijie Ma, Sixi Wei, Qianping Li, Ruiwu Liu, Randy P. Carney, Kevin Yang, Joyce Lee, Alan Nyugen, Ken Y. Yoneda, Kit S. Lam, Tianhong Li
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Hematology & Oncology
Subjects:
Cancer-targeting peptide
α3β1 integrin
Non-small cell lung cancer
Exosomes
In vivo imaging
Patient-derived xenograft
Online Access:http://link.springer.com/article/10.1186/s13045-019-0740-7

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