Assessment of oxidative stress in babies under phototherapy for neonatal jaundice
Background: Neonatal jaundice is a common condition that can be treated with phototherapy. Phototherapy may cause oxidative stress in addition to the usual side effects. Aim: In this study, the oxidative stress in babies with neonatal jaundice was assessed before and after phototherapy by estimating...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | International Journal of Advanced Medical and Health Research |
| Subjects: | |
| Online Access: | http://www.ijamhrjournal.org/article.asp?issn=2349-4220;year=2014;volume=1;issue=2;spage=66;epage=68;aulast=Thiagarajan |
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| author | Anitha Nancy Thiagarajan Parkash Chand Ballambattu Vishnu Bhat Magadi Gopalakrishna Sridhar |
| author_facet | Anitha Nancy Thiagarajan Parkash Chand Ballambattu Vishnu Bhat Magadi Gopalakrishna Sridhar |
| author_sort | Anitha Nancy Thiagarajan |
| collection | DOAJ |
| description | Background: Neonatal jaundice is a common condition that can be treated with phototherapy. Phototherapy may cause oxidative stress in addition to the usual side effects. Aim: In this study, the oxidative stress in babies with neonatal jaundice was assessed before and after phototherapy by estimating plasma malondialdehyde (MDA) level. Methods: Eighty babies with neonatal jaundice were chosen for the study. Among them, 40 babies whose total serum bilirubin level was >15 mg/dl formed the case group and the other 40 babies with total serum bilirubin level <15 mg/dl who did not require phototherapy formed the control group. Total serum bilirubin was measured using Automated Clinical Chemical Analyser with standard reagent kit. Plasma MDA was estimated by Satoh′s method using spectrophotometry. Results: The plasma MDA level, which is one of the oxidant markers, was significantly elevated in post-phototherapy cases compared to pre-phototherapy and controls. Conclusion: Phototherapy results in significant oxidative stress among babies with neonatal hyperbilirubinemia. So, usage of phototherapy should be restricted to those with significant hyperbilirubinemia. |
| first_indexed | 2024-12-10T14:12:29Z |
| format | Article |
| id | doaj.art-d3b82ca7f03b41a29a3c84b7de49a5ac |
| institution | Directory Open Access Journal |
| issn | 2349-4220 2350-0298 |
| language | English |
| last_indexed | 2024-12-10T14:12:29Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Advanced Medical and Health Research |
| spelling | doaj.art-d3b82ca7f03b41a29a3c84b7de49a5ac2022-12-22T01:45:26ZengWolters Kluwer Medknow PublicationsInternational Journal of Advanced Medical and Health Research2349-42202350-02982014-01-0112666810.4103/2349-4220.148004Assessment of oxidative stress in babies under phototherapy for neonatal jaundiceAnitha Nancy ThiagarajanParkash ChandBallambattu Vishnu BhatMagadi Gopalakrishna SridharBackground: Neonatal jaundice is a common condition that can be treated with phototherapy. Phototherapy may cause oxidative stress in addition to the usual side effects. Aim: In this study, the oxidative stress in babies with neonatal jaundice was assessed before and after phototherapy by estimating plasma malondialdehyde (MDA) level. Methods: Eighty babies with neonatal jaundice were chosen for the study. Among them, 40 babies whose total serum bilirubin level was >15 mg/dl formed the case group and the other 40 babies with total serum bilirubin level <15 mg/dl who did not require phototherapy formed the control group. Total serum bilirubin was measured using Automated Clinical Chemical Analyser with standard reagent kit. Plasma MDA was estimated by Satoh′s method using spectrophotometry. Results: The plasma MDA level, which is one of the oxidant markers, was significantly elevated in post-phototherapy cases compared to pre-phototherapy and controls. Conclusion: Phototherapy results in significant oxidative stress among babies with neonatal hyperbilirubinemia. So, usage of phototherapy should be restricted to those with significant hyperbilirubinemia.http://www.ijamhrjournal.org/article.asp?issn=2349-4220;year=2014;volume=1;issue=2;spage=66;epage=68;aulast=ThiagarajanMalondialdehyde levelneonatal jaundiceoxidative stressphototherapy |
| spellingShingle | Anitha Nancy Thiagarajan Parkash Chand Ballambattu Vishnu Bhat Magadi Gopalakrishna Sridhar Assessment of oxidative stress in babies under phototherapy for neonatal jaundice International Journal of Advanced Medical and Health Research Malondialdehyde level neonatal jaundice oxidative stress phototherapy |
| title | Assessment of oxidative stress in babies under phototherapy for neonatal jaundice |
| title_full | Assessment of oxidative stress in babies under phototherapy for neonatal jaundice |
| title_fullStr | Assessment of oxidative stress in babies under phototherapy for neonatal jaundice |
| title_full_unstemmed | Assessment of oxidative stress in babies under phototherapy for neonatal jaundice |
| title_short | Assessment of oxidative stress in babies under phototherapy for neonatal jaundice |
| title_sort | assessment of oxidative stress in babies under phototherapy for neonatal jaundice |
| topic | Malondialdehyde level neonatal jaundice oxidative stress phototherapy |
| url | http://www.ijamhrjournal.org/article.asp?issn=2349-4220;year=2014;volume=1;issue=2;spage=66;epage=68;aulast=Thiagarajan |
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