Hematological profile, inflammatory markers and serum liver enzymes in COVID 19 positive children vs. COVID 19 negative ones—a comparative study
BackgroundComplete blood count, C-reactive protein and transaminases are routine laboratory parameters investigated in children with infections, including COVID 19. We aimed to evaluate the diagnostic accuracy of these parameters in children diagnosed with COVID 19.MethodsAt the time of admission, c...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1334591/full |
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| author | Mirela Luminița Pavelescu Mirela Luminița Pavelescu Alexandru Dinulescu Alexandru Dinulescu Alexandru-Sorin Păsărică Irina Dijmărescu Irina Dijmărescu Daniela Păcurar Daniela Păcurar |
| author_facet | Mirela Luminița Pavelescu Mirela Luminița Pavelescu Alexandru Dinulescu Alexandru Dinulescu Alexandru-Sorin Păsărică Irina Dijmărescu Irina Dijmărescu Daniela Păcurar Daniela Păcurar |
| author_sort | Mirela Luminița Pavelescu |
| collection | DOAJ |
| description | BackgroundComplete blood count, C-reactive protein and transaminases are routine laboratory parameters investigated in children with infections, including COVID 19. We aimed to evaluate the diagnostic accuracy of these parameters in children diagnosed with COVID 19.MethodsAt the time of admission, children with COVID 19 suggestive symptoms were tested RT-PCR for SARS CoV-2 and were allocated to either the study group (RT-PCR SARS CoV-2 positive) or control group (RT-PCR SARS CoV-2 negative). All children were evaluated by complete blood count, CRP, and transaminases.ResultsWhen comparing the two groups, we identified significantly lower values for leukocytes (p < 0.001), neutrophils (p < 0.001), lymphocytes (p < 0.001) and thrombocytes (p = 0.014), but no significantly different values for CRP (p = 0.916) and monocytes (p = 0.082). A diagnostic score for COVID-19 was compiled using the abovementioned parameters—presence of fever, number of lymphocytes and aspartate-aminotransferase. Performance was tested, showing a positive discrimination value (AUC of 0.703)—81.5% sensitivity, 50.6% specificity.ConclusionsThe leukocytes, neutrophils and lymphocytes have significantly lower values in COVID-19 children. The proposed score based on the presence of fever the values of lymphocytes and AST has a good sensitivity in predicting COVID-19 infection. |
| first_indexed | 2024-03-08T00:51:24Z |
| format | Article |
| id | doaj.art-d3b8368c1a754e3fa9b33427d869e2f9 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-24T13:20:50Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-d3b8368c1a754e3fa9b33427d869e2f92024-04-04T15:25:43ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602024-02-011210.3389/fped.2024.13345911334591Hematological profile, inflammatory markers and serum liver enzymes in COVID 19 positive children vs. COVID 19 negative ones—a comparative studyMirela Luminița Pavelescu0Mirela Luminița Pavelescu1Alexandru Dinulescu2Alexandru Dinulescu3Alexandru-Sorin Păsărică4Irina Dijmărescu5Irina Dijmărescu6Daniela Păcurar7Daniela Păcurar8Departament of Pediatrics, “Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaDepartment of Pediatrics, “Grigore Alexandrescu” Emergency Children's Hospital, Bucharest, RomaniaDepartament of Pediatrics, “Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaDepartment of Pediatrics, “Grigore Alexandrescu” Emergency Children's Hospital, Bucharest, RomaniaDepartment of Pediatrics, “Grigore Alexandrescu” Emergency Children's Hospital, Bucharest, RomaniaDepartament of Pediatrics, “Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaDepartment of Pediatrics, “Grigore Alexandrescu” Emergency Children's Hospital, Bucharest, RomaniaDepartament of Pediatrics, “Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaDepartment of Pediatrics, “Grigore Alexandrescu” Emergency Children's Hospital, Bucharest, RomaniaBackgroundComplete blood count, C-reactive protein and transaminases are routine laboratory parameters investigated in children with infections, including COVID 19. We aimed to evaluate the diagnostic accuracy of these parameters in children diagnosed with COVID 19.MethodsAt the time of admission, children with COVID 19 suggestive symptoms were tested RT-PCR for SARS CoV-2 and were allocated to either the study group (RT-PCR SARS CoV-2 positive) or control group (RT-PCR SARS CoV-2 negative). All children were evaluated by complete blood count, CRP, and transaminases.ResultsWhen comparing the two groups, we identified significantly lower values for leukocytes (p < 0.001), neutrophils (p < 0.001), lymphocytes (p < 0.001) and thrombocytes (p = 0.014), but no significantly different values for CRP (p = 0.916) and monocytes (p = 0.082). A diagnostic score for COVID-19 was compiled using the abovementioned parameters—presence of fever, number of lymphocytes and aspartate-aminotransferase. Performance was tested, showing a positive discrimination value (AUC of 0.703)—81.5% sensitivity, 50.6% specificity.ConclusionsThe leukocytes, neutrophils and lymphocytes have significantly lower values in COVID-19 children. The proposed score based on the presence of fever the values of lymphocytes and AST has a good sensitivity in predicting COVID-19 infection.https://www.frontiersin.org/articles/10.3389/fped.2024.1334591/fullSARS CoV-2COVID-19complete blood countC-reactive proteintransaminases |
| spellingShingle | Mirela Luminița Pavelescu Mirela Luminița Pavelescu Alexandru Dinulescu Alexandru Dinulescu Alexandru-Sorin Păsărică Irina Dijmărescu Irina Dijmărescu Daniela Păcurar Daniela Păcurar Hematological profile, inflammatory markers and serum liver enzymes in COVID 19 positive children vs. COVID 19 negative ones—a comparative study Frontiers in Pediatrics SARS CoV-2 COVID-19 complete blood count C-reactive protein transaminases |
| title | Hematological profile, inflammatory markers and serum liver enzymes in COVID 19 positive children vs. COVID 19 negative ones—a comparative study |
| title_full | Hematological profile, inflammatory markers and serum liver enzymes in COVID 19 positive children vs. COVID 19 negative ones—a comparative study |
| title_fullStr | Hematological profile, inflammatory markers and serum liver enzymes in COVID 19 positive children vs. COVID 19 negative ones—a comparative study |
| title_full_unstemmed | Hematological profile, inflammatory markers and serum liver enzymes in COVID 19 positive children vs. COVID 19 negative ones—a comparative study |
| title_short | Hematological profile, inflammatory markers and serum liver enzymes in COVID 19 positive children vs. COVID 19 negative ones—a comparative study |
| title_sort | hematological profile inflammatory markers and serum liver enzymes in covid 19 positive children vs covid 19 negative ones a comparative study |
| topic | SARS CoV-2 COVID-19 complete blood count C-reactive protein transaminases |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1334591/full |
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