Propensity Score-Matched Analysis of Lesion Patterns in Stroke Patients With Patent Foramen Ovale and Patients With Spontaneous Intracranial Artery Dissection
Aims: To investigate the relationship between clinical and imaging features of stroke patients with patent foramen ovale (PFO) and those with spontaneous intracranial artery dissection (SIAD).Materials and methods: We retrospectively examined both clinical and imaging results of 40 stroke patients w...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-04-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.00418/full |
| _version_ | 1818993162094379008 |
|---|---|
| author | Yangyang Huang Yangyang Huang Yifan Cheng Bei Shao Xuanyou Zhou Huazheng Liang Jianhua Zhuang Yong Bi |
| author_facet | Yangyang Huang Yangyang Huang Yifan Cheng Bei Shao Xuanyou Zhou Huazheng Liang Jianhua Zhuang Yong Bi |
| author_sort | Yangyang Huang |
| collection | DOAJ |
| description | Aims: To investigate the relationship between clinical and imaging features of stroke patients with patent foramen ovale (PFO) and those with spontaneous intracranial artery dissection (SIAD).Materials and methods: We retrospectively examined both clinical and imaging results of 40 stroke patients with PFO and 29 with SIAD. To reduce selection bias, we conducted a propensity score-matching analysis. The patients' propensity scores were estimated using a logistic regression model based on the following variables: age, sex, hypertension, diabetes mellitus, hypercholesterolemia, cigarette smoking, stroke histories, and their NIHSS scores. We compared the pattern of cerebral DWI lesions between patients with PFO and those with SIAD.Results: After propensity score matching, 21 pairs of patients were selected. Clinical characteristics of the 2 groups were well matched. The distribution of DWI lesion patterns differed between the 2 groups. Single lesions (cortical or subcortical) were more frequently observed in the PFO group than in the SIAD group (P = 0.026). Multiple lesions in one vascular territory occurred more frequently in the SIAD group than in the PFO group (P = 0.035).Conclusion: The present study suggests that lesion patterns observed from DWI of patients with PFO and SIAD might provide clues to the etiology of infarcts. Single lesions (cortical or subcortical) might be a typical feature of PFO associated strokes, while multiple lesions in one vascular territory might be a specific feature of SIAD associated strokes. |
| first_indexed | 2024-12-20T20:37:40Z |
| format | Article |
| id | doaj.art-d3b9d22900744991b6a7313e51aca9d8 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-20T20:37:40Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-d3b9d22900744991b6a7313e51aca9d82022-12-21T19:27:11ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-04-011010.3389/fneur.2019.00418446149Propensity Score-Matched Analysis of Lesion Patterns in Stroke Patients With Patent Foramen Ovale and Patients With Spontaneous Intracranial Artery DissectionYangyang Huang0Yangyang Huang1Yifan Cheng2Bei Shao3Xuanyou Zhou4Huazheng Liang5Jianhua Zhuang6Yong Bi7Department of Neurology, Shanghai Fourth People's Hospital, Tongji University, Shanghai, ChinaDepartment of Neurology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, ChinaThe First Clinical Medical Institute, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, Shanghai Fourth People's Hospital, Tongji University, Shanghai, ChinaDepartment of Neurology, Changzheng Hospital, Second Military Medical University, Shanghai, ChinaDepartment of Neurology, Shanghai Fourth People's Hospital, Tongji University, Shanghai, ChinaAims: To investigate the relationship between clinical and imaging features of stroke patients with patent foramen ovale (PFO) and those with spontaneous intracranial artery dissection (SIAD).Materials and methods: We retrospectively examined both clinical and imaging results of 40 stroke patients with PFO and 29 with SIAD. To reduce selection bias, we conducted a propensity score-matching analysis. The patients' propensity scores were estimated using a logistic regression model based on the following variables: age, sex, hypertension, diabetes mellitus, hypercholesterolemia, cigarette smoking, stroke histories, and their NIHSS scores. We compared the pattern of cerebral DWI lesions between patients with PFO and those with SIAD.Results: After propensity score matching, 21 pairs of patients were selected. Clinical characteristics of the 2 groups were well matched. The distribution of DWI lesion patterns differed between the 2 groups. Single lesions (cortical or subcortical) were more frequently observed in the PFO group than in the SIAD group (P = 0.026). Multiple lesions in one vascular territory occurred more frequently in the SIAD group than in the PFO group (P = 0.035).Conclusion: The present study suggests that lesion patterns observed from DWI of patients with PFO and SIAD might provide clues to the etiology of infarcts. Single lesions (cortical or subcortical) might be a typical feature of PFO associated strokes, while multiple lesions in one vascular territory might be a specific feature of SIAD associated strokes.https://www.frontiersin.org/article/10.3389/fneur.2019.00418/fullpatent foramen ovalespontaneous intracranial artery dissectionischemic strokeembolismDWI |
| spellingShingle | Yangyang Huang Yangyang Huang Yifan Cheng Bei Shao Xuanyou Zhou Huazheng Liang Jianhua Zhuang Yong Bi Propensity Score-Matched Analysis of Lesion Patterns in Stroke Patients With Patent Foramen Ovale and Patients With Spontaneous Intracranial Artery Dissection Frontiers in Neurology patent foramen ovale spontaneous intracranial artery dissection ischemic stroke embolism DWI |
| title | Propensity Score-Matched Analysis of Lesion Patterns in Stroke Patients With Patent Foramen Ovale and Patients With Spontaneous Intracranial Artery Dissection |
| title_full | Propensity Score-Matched Analysis of Lesion Patterns in Stroke Patients With Patent Foramen Ovale and Patients With Spontaneous Intracranial Artery Dissection |
| title_fullStr | Propensity Score-Matched Analysis of Lesion Patterns in Stroke Patients With Patent Foramen Ovale and Patients With Spontaneous Intracranial Artery Dissection |
| title_full_unstemmed | Propensity Score-Matched Analysis of Lesion Patterns in Stroke Patients With Patent Foramen Ovale and Patients With Spontaneous Intracranial Artery Dissection |
| title_short | Propensity Score-Matched Analysis of Lesion Patterns in Stroke Patients With Patent Foramen Ovale and Patients With Spontaneous Intracranial Artery Dissection |
| title_sort | propensity score matched analysis of lesion patterns in stroke patients with patent foramen ovale and patients with spontaneous intracranial artery dissection |
| topic | patent foramen ovale spontaneous intracranial artery dissection ischemic stroke embolism DWI |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.00418/full |
| work_keys_str_mv | AT yangyanghuang propensityscorematchedanalysisoflesionpatternsinstrokepatientswithpatentforamenovaleandpatientswithspontaneousintracranialarterydissection AT yangyanghuang propensityscorematchedanalysisoflesionpatternsinstrokepatientswithpatentforamenovaleandpatientswithspontaneousintracranialarterydissection AT yifancheng propensityscorematchedanalysisoflesionpatternsinstrokepatientswithpatentforamenovaleandpatientswithspontaneousintracranialarterydissection AT beishao propensityscorematchedanalysisoflesionpatternsinstrokepatientswithpatentforamenovaleandpatientswithspontaneousintracranialarterydissection AT xuanyouzhou propensityscorematchedanalysisoflesionpatternsinstrokepatientswithpatentforamenovaleandpatientswithspontaneousintracranialarterydissection AT huazhengliang propensityscorematchedanalysisoflesionpatternsinstrokepatientswithpatentforamenovaleandpatientswithspontaneousintracranialarterydissection AT jianhuazhuang propensityscorematchedanalysisoflesionpatternsinstrokepatientswithpatentforamenovaleandpatientswithspontaneousintracranialarterydissection AT yongbi propensityscorematchedanalysisoflesionpatternsinstrokepatientswithpatentforamenovaleandpatientswithspontaneousintracranialarterydissection |