Influence of emicizumab on protein C-mediated clotting regulation

Influence of emicizumab on protein C-mediated clotting regulation

Emicizumab, a FVIII-mimetic bispecific antibody, is insensitive to degradation by activated protein C (APC) and may thus induce a procoagulant state. We investigated the effect of emicizumab on protein C-mediated inhibition of coagulation under in vitro conditions mimicking physiological and pathol...

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Bibliographic Details
Main Authors: Federica Mancazzo, Antonia Vitulli, Lavinia Dirienzo, Concetta T. Ammollo, Fabrizio Semeraro, Mario Colucci
Format: Article
Language:English
Published: PAGEPress Publications 2023-10-01
Series:Bleeding, Thrombosis and Vascular Biology
Subjects:
Emicizumab
protein C resistance
intrinsic pathway
thrombotic risk
Online Access:https://btvb.org/btvb/article/view/89

Internet

https://btvb.org/btvb/article/view/89

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