Multicenter experiences in temporal bone cancer surgery based on 89 cases.
OBJECTIVE:To present outcomes of extensive surgery: lateral, subtotal, total petrosectomies in patients with temporal bone invasion resulting from specific primary cancers. STUDY DESIGN:Retrospective case review. SETTING:Four tertiary referral centers. MATERIAL:89 patients with cancer of the tempora...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5321293?pdf=render |
| _version_ | 1818511064297373696 |
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| author | Małgorzata Wierzbicka Kazimierz Niemczyk Antoni Bruzgielewicz Marcin Durko Janusz Klatka Tomasz Kopeć Ewa Osuch-Wójcikiewicz Wioletta Pietruszewska Marcin Szymański Witold Szyfter |
| author_facet | Małgorzata Wierzbicka Kazimierz Niemczyk Antoni Bruzgielewicz Marcin Durko Janusz Klatka Tomasz Kopeć Ewa Osuch-Wójcikiewicz Wioletta Pietruszewska Marcin Szymański Witold Szyfter |
| author_sort | Małgorzata Wierzbicka |
| collection | DOAJ |
| description | OBJECTIVE:To present outcomes of extensive surgery: lateral, subtotal, total petrosectomies in patients with temporal bone invasion resulting from specific primary cancers. STUDY DESIGN:Retrospective case review. SETTING:Four tertiary referral centers. MATERIAL:89 patients with cancer of the temporal bone treated between January 2006 and December 2010. INTERVENTION:Multidisciplinary team approach including surgical resection, reconstruction, and postoperative radiotherapy. MAIN OUTCOME MEASURE:Disease-specific survival, overall survival. RESULTS:In 27.0% of the patients, relapse was reported, with an average of 6.3 months after surgery; 31 patients (34.8%) died during the follow-up. The average mortality was 22.1 months. Fifty-four patients (58.7%) stayed alive during the time of observation. The average survival time was 42.0 months. The median time of survival with relapse was 12 months (range: 1-51 months). The three-year disease-free rate was 38.0% and the overall survival rate was 58.7%. CONCLUSIONS:Petrosectomy is an effective treatment for malignant temporal bone invasion. The probability of a good outcome was statistically decreased with a high T grade, positive margins, and salvage surgery. Younger age is connected with better prognosis. One of the major tasks remains to improve detection and to shorten the time to diagnosis, keeping in mind that symptoms are insidious and in younger people, the time before diagnosis was longer. |
| first_indexed | 2024-12-10T23:28:25Z |
| format | Article |
| id | doaj.art-d3bd82e5a281492fb4f1129002137cec |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T23:28:25Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d3bd82e5a281492fb4f1129002137cec2022-12-22T01:29:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01122e016939910.1371/journal.pone.0169399Multicenter experiences in temporal bone cancer surgery based on 89 cases.Małgorzata WierzbickaKazimierz NiemczykAntoni BruzgielewiczMarcin DurkoJanusz KlatkaTomasz KopećEwa Osuch-WójcikiewiczWioletta PietruszewskaMarcin SzymańskiWitold SzyfterOBJECTIVE:To present outcomes of extensive surgery: lateral, subtotal, total petrosectomies in patients with temporal bone invasion resulting from specific primary cancers. STUDY DESIGN:Retrospective case review. SETTING:Four tertiary referral centers. MATERIAL:89 patients with cancer of the temporal bone treated between January 2006 and December 2010. INTERVENTION:Multidisciplinary team approach including surgical resection, reconstruction, and postoperative radiotherapy. MAIN OUTCOME MEASURE:Disease-specific survival, overall survival. RESULTS:In 27.0% of the patients, relapse was reported, with an average of 6.3 months after surgery; 31 patients (34.8%) died during the follow-up. The average mortality was 22.1 months. Fifty-four patients (58.7%) stayed alive during the time of observation. The average survival time was 42.0 months. The median time of survival with relapse was 12 months (range: 1-51 months). The three-year disease-free rate was 38.0% and the overall survival rate was 58.7%. CONCLUSIONS:Petrosectomy is an effective treatment for malignant temporal bone invasion. The probability of a good outcome was statistically decreased with a high T grade, positive margins, and salvage surgery. Younger age is connected with better prognosis. One of the major tasks remains to improve detection and to shorten the time to diagnosis, keeping in mind that symptoms are insidious and in younger people, the time before diagnosis was longer.http://europepmc.org/articles/PMC5321293?pdf=render |
| spellingShingle | Małgorzata Wierzbicka Kazimierz Niemczyk Antoni Bruzgielewicz Marcin Durko Janusz Klatka Tomasz Kopeć Ewa Osuch-Wójcikiewicz Wioletta Pietruszewska Marcin Szymański Witold Szyfter Multicenter experiences in temporal bone cancer surgery based on 89 cases. PLoS ONE |
| title | Multicenter experiences in temporal bone cancer surgery based on 89 cases. |
| title_full | Multicenter experiences in temporal bone cancer surgery based on 89 cases. |
| title_fullStr | Multicenter experiences in temporal bone cancer surgery based on 89 cases. |
| title_full_unstemmed | Multicenter experiences in temporal bone cancer surgery based on 89 cases. |
| title_short | Multicenter experiences in temporal bone cancer surgery based on 89 cases. |
| title_sort | multicenter experiences in temporal bone cancer surgery based on 89 cases |
| url | http://europepmc.org/articles/PMC5321293?pdf=render |
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