Protective Effects of Therapeutic Neutrophil Depletion and Myeloperoxidase Inhibition on Left Ventricular Function and Remodeling in Myocardial Infarction

Protective Effects of Therapeutic Neutrophil Depletion and Myeloperoxidase Inhibition on Left Ventricular Function and Remodeling in Myocardial Infarction

Myocardial infarction (MI) is a leading cause of morbidity and mortality worldwide. Improved survival has led to an increasing incidence of ischemic cardiomyopathy, making it a major reason for hospitalization in the western world. The inflammatory response in the ischemic myocardium determines the...

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Bibliographic Details
Main Authors: Henning Guthoff, Alexander Hof, Anna Klinke, Martina Maaß, Jürgen Konradi, Dennis Mehrkens, Simon Geißen, Felix S. Nettersheim, Simon Braumann, Erik Michaelsson, Richard J. Nies, Samuel Lee, Marie-Christin Redzinski, Vera B. M. Peters, Harshal N. Nemade, Philipp von Stein, Holger Winkels, Volker Rudolph, Stephan Baldus, Matti Adam, Martin Mollenhauer
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Antioxidants
Subjects:
myocardial infarction
ischemic cardiomyopathy
myocardial remodeling
polymorphonuclear neutrophils
myeloperoxidase
MPO inhibition
Online Access:https://www.mdpi.com/2076-3921/12/1/33

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