Salt-inducible kinase 3 regulates the mammalian circadian clock by destabilizing PER2 protein

Salt-inducible kinase 3 regulates the mammalian circadian clock by destabilizing PER2 protein

Salt-inducible kinase 3 (SIK3) plays a crucial role in various aspects of metabolism. In the course of investigating metabolic defects in Sik3-deficient mice (Sik3-/-), we observed that circadian rhythmicity of the metabolisms was phase-delayed. Sik3-/- mice also exhibited other circadian abnormalit...

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Bibliographic Details
Main Authors: Naoto Hayasaka, Arisa Hirano, Yuka Miyoshi, Isao T Tokuda, Hikari Yoshitane, Junichiro Matsuda, Yoshitaka Fukada
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-12-01
Series:eLife
Subjects:
SIK3
knockout
circadian rhythm
PER2
degradation
salt-inducible kinase
Online Access:https://elifesciences.org/articles/24779

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