Synchronous RNA conformational changes trigger ordered phase transitions in crystals
Time-resolved crystallography (TRX) is used for monitoring only small conformational changes of biomacromolecules within the same lattice. Here, the authors report the interplay between synchronous molecular rearrangements and lattice phase transitions in RNA crystals, providing the basis for the in...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21838-5 |
| _version_ | 1818400552896167936 |
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| author | Saminathan Ramakrishnan Jason R. Stagno Chelsie E. Conrad Jienyu Ding Ping Yu Yuba R. Bhandari Yun-Tzai Lee Gary Pauly Oleksandr Yefanov Max O. Wiedorn Juraj Knoska Dominik Oberthür Thomas A. White Anton Barty Valerio Mariani Chufeng Li Wolfgang Brehm William F. Heinz Valentin Magidson Stephen Lockett Mark S. Hunter Sébastien Boutet Nadia A. Zatsepin Xiaobing Zuo Thomas D. Grant Suraj Pandey Marius Schmidt John C. H. Spence Henry N. Chapman Yun-Xing Wang |
| author_facet | Saminathan Ramakrishnan Jason R. Stagno Chelsie E. Conrad Jienyu Ding Ping Yu Yuba R. Bhandari Yun-Tzai Lee Gary Pauly Oleksandr Yefanov Max O. Wiedorn Juraj Knoska Dominik Oberthür Thomas A. White Anton Barty Valerio Mariani Chufeng Li Wolfgang Brehm William F. Heinz Valentin Magidson Stephen Lockett Mark S. Hunter Sébastien Boutet Nadia A. Zatsepin Xiaobing Zuo Thomas D. Grant Suraj Pandey Marius Schmidt John C. H. Spence Henry N. Chapman Yun-Xing Wang |
| author_sort | Saminathan Ramakrishnan |
| collection | DOAJ |
| description | Time-resolved crystallography (TRX) is used for monitoring only small conformational changes of biomacromolecules within the same lattice. Here, the authors report the interplay between synchronous molecular rearrangements and lattice phase transitions in RNA crystals, providing the basis for the investigation of large conformational changes using TRX. |
| first_indexed | 2024-12-14T07:38:24Z |
| format | Article |
| id | doaj.art-d3c2ae5ddc16425aacc1cbd35314f690 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T07:38:24Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d3c2ae5ddc16425aacc1cbd35314f6902022-12-21T23:11:07ZengNature PortfolioNature Communications2041-17232021-03-0112111010.1038/s41467-021-21838-5Synchronous RNA conformational changes trigger ordered phase transitions in crystalsSaminathan Ramakrishnan0Jason R. Stagno1Chelsie E. Conrad2Jienyu Ding3Ping Yu4Yuba R. Bhandari5Yun-Tzai Lee6Gary Pauly7Oleksandr Yefanov8Max O. Wiedorn9Juraj Knoska10Dominik Oberthür11Thomas A. White12Anton Barty13Valerio Mariani14Chufeng Li15Wolfgang Brehm16William F. Heinz17Valentin Magidson18Stephen Lockett19Mark S. Hunter20Sébastien Boutet21Nadia A. Zatsepin22Xiaobing Zuo23Thomas D. Grant24Suraj Pandey25Marius Schmidt26John C. H. Spence27Henry N. Chapman28Yun-Xing Wang29Structural Biophysics Laboratory, National Cancer InstituteStructural Biophysics Laboratory, National Cancer InstituteStructural Biophysics Laboratory, National Cancer InstituteStructural Biophysics Laboratory, National Cancer InstituteStructural Biophysics Laboratory, National Cancer InstituteStructural Biophysics Laboratory, National Cancer InstituteStructural Biophysics Laboratory, National Cancer InstituteChemical Biology Laboratory, Center for Cancer Research, National Cancer InstituteCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYOptical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer ResearchOptical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer ResearchOptical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer ResearchLinac Coherent Light Source, SLAC National Accelerator LaboratoryLinac Coherent Light Source, SLAC National Accelerator LaboratoryDepartment of Physics, Arizona State UniversityX-ray Science Division, Argonne National LaboratoryDepartment of Structural Biology, Jacobs School of Medicine and Biomedical Sciences, SUNY University at BuffaloKenwood Interdisciplinary Research Complex Physics Department, University of Wisconsin-MilwaukeeKenwood Interdisciplinary Research Complex Physics Department, University of Wisconsin-MilwaukeeDepartment of Physics, Arizona State UniversityCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYStructural Biophysics Laboratory, National Cancer InstituteTime-resolved crystallography (TRX) is used for monitoring only small conformational changes of biomacromolecules within the same lattice. Here, the authors report the interplay between synchronous molecular rearrangements and lattice phase transitions in RNA crystals, providing the basis for the investigation of large conformational changes using TRX.https://doi.org/10.1038/s41467-021-21838-5 |
| spellingShingle | Saminathan Ramakrishnan Jason R. Stagno Chelsie E. Conrad Jienyu Ding Ping Yu Yuba R. Bhandari Yun-Tzai Lee Gary Pauly Oleksandr Yefanov Max O. Wiedorn Juraj Knoska Dominik Oberthür Thomas A. White Anton Barty Valerio Mariani Chufeng Li Wolfgang Brehm William F. Heinz Valentin Magidson Stephen Lockett Mark S. Hunter Sébastien Boutet Nadia A. Zatsepin Xiaobing Zuo Thomas D. Grant Suraj Pandey Marius Schmidt John C. H. Spence Henry N. Chapman Yun-Xing Wang Synchronous RNA conformational changes trigger ordered phase transitions in crystals Nature Communications |
| title | Synchronous RNA conformational changes trigger ordered phase transitions in crystals |
| title_full | Synchronous RNA conformational changes trigger ordered phase transitions in crystals |
| title_fullStr | Synchronous RNA conformational changes trigger ordered phase transitions in crystals |
| title_full_unstemmed | Synchronous RNA conformational changes trigger ordered phase transitions in crystals |
| title_short | Synchronous RNA conformational changes trigger ordered phase transitions in crystals |
| title_sort | synchronous rna conformational changes trigger ordered phase transitions in crystals |
| url | https://doi.org/10.1038/s41467-021-21838-5 |
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