Clinical analysis of Kimura’s disease in 24 cases from China
Abstract Background We reviewed details of Chinese Kimura’s disease (KD) cases. A full clinical analysis was subsequently performed to improve the accuracy of clinical diagnosis and treatment of KD. Methods A total of 24 patients with pathologically confirmed KD treated between March 2008 and March...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-01-01
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| Series: | BMC Surgery |
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| Online Access: | https://doi.org/10.1186/s12893-019-0673-7 |
| _version_ | 1818662292406927360 |
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| author | Guoliang Zhang Xumao Li Guangbin Sun Yitan Cao Nan Gao Weidong Qi |
| author_facet | Guoliang Zhang Xumao Li Guangbin Sun Yitan Cao Nan Gao Weidong Qi |
| author_sort | Guoliang Zhang |
| collection | DOAJ |
| description | Abstract Background We reviewed details of Chinese Kimura’s disease (KD) cases. A full clinical analysis was subsequently performed to improve the accuracy of clinical diagnosis and treatment of KD. Methods A total of 24 patients with pathologically confirmed KD treated between March 2008 and March 2018 were reviewed retrospectively for clinical and histopathological analysis. Results In the 24 KD cases, 20 were male and 4 were female with the age of onset ranging from 5 to 65 years. Lesion diameter ranged from 0.6 cm to 7 cm with unilateral involvement being more popular (79%). Imaging examination had a high detection rate for KD involving the parotid gland and subcutaneous but had low specificity. Microscopic analysis indicated that KD mainly involved subcutaneous soft tissue and lymph nodes. The prominent feature of lymphoid tissue was germinal center hyperplasia surrounded by several lobules associated with hyperplastic vascular structures. Out of the 24 patients, 11 experienced recurrence of disease after treatment (surgical resection: 46.2%, surgical resection followed by oral corticosteroids: 71.4% and surgical resection combined with radiotherapy: 0%). Conclusions Our analysis revealed clinical, imaging, and histological characteristics of KD. A better understanding of the disease will help clinicians reduce misdiagnosis and improve the diagnostic rate upon patient first clinical visit. |
| first_indexed | 2024-12-17T04:58:38Z |
| format | Article |
| id | doaj.art-d3c3d453ef054f21b014a29377952931 |
| institution | Directory Open Access Journal |
| issn | 1471-2482 |
| language | English |
| last_indexed | 2024-12-17T04:58:38Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Surgery |
| spelling | doaj.art-d3c3d453ef054f21b014a293779529312022-12-21T22:02:38ZengBMCBMC Surgery1471-24822020-01-012011610.1186/s12893-019-0673-7Clinical analysis of Kimura’s disease in 24 cases from ChinaGuoliang Zhang0Xumao Li1Guangbin Sun2Yitan Cao3Nan Gao4Weidong Qi5Department of Otorhinolaryngology, Affiliated Huashan Hospital, Fudan UniversityDepartment of Otorhinolaryngology, Affiliated Huashan Hospital, Fudan UniversityDepartment of Otorhinolaryngology, Affiliated Huashan Hospital, Fudan UniversityDepartment of Otorhinolaryngology, Affiliated Huashan Hospital, Fudan UniversityDepartment of Otorhinolaryngology, Affiliated Huashan Hospital, Fudan UniversityDepartment of Otorhinolaryngology, Affiliated Huashan Hospital, Fudan UniversityAbstract Background We reviewed details of Chinese Kimura’s disease (KD) cases. A full clinical analysis was subsequently performed to improve the accuracy of clinical diagnosis and treatment of KD. Methods A total of 24 patients with pathologically confirmed KD treated between March 2008 and March 2018 were reviewed retrospectively for clinical and histopathological analysis. Results In the 24 KD cases, 20 were male and 4 were female with the age of onset ranging from 5 to 65 years. Lesion diameter ranged from 0.6 cm to 7 cm with unilateral involvement being more popular (79%). Imaging examination had a high detection rate for KD involving the parotid gland and subcutaneous but had low specificity. Microscopic analysis indicated that KD mainly involved subcutaneous soft tissue and lymph nodes. The prominent feature of lymphoid tissue was germinal center hyperplasia surrounded by several lobules associated with hyperplastic vascular structures. Out of the 24 patients, 11 experienced recurrence of disease after treatment (surgical resection: 46.2%, surgical resection followed by oral corticosteroids: 71.4% and surgical resection combined with radiotherapy: 0%). Conclusions Our analysis revealed clinical, imaging, and histological characteristics of KD. A better understanding of the disease will help clinicians reduce misdiagnosis and improve the diagnostic rate upon patient first clinical visit.https://doi.org/10.1186/s12893-019-0673-7Kimura’s diseaseEosinophiliaHistopathologyTreatment |
| spellingShingle | Guoliang Zhang Xumao Li Guangbin Sun Yitan Cao Nan Gao Weidong Qi Clinical analysis of Kimura’s disease in 24 cases from China BMC Surgery Kimura’s disease Eosinophilia Histopathology Treatment |
| title | Clinical analysis of Kimura’s disease in 24 cases from China |
| title_full | Clinical analysis of Kimura’s disease in 24 cases from China |
| title_fullStr | Clinical analysis of Kimura’s disease in 24 cases from China |
| title_full_unstemmed | Clinical analysis of Kimura’s disease in 24 cases from China |
| title_short | Clinical analysis of Kimura’s disease in 24 cases from China |
| title_sort | clinical analysis of kimura s disease in 24 cases from china |
| topic | Kimura’s disease Eosinophilia Histopathology Treatment |
| url | https://doi.org/10.1186/s12893-019-0673-7 |
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