Rufinamide, a Triazole-Derived Antiepileptic Drug, Stimulates Ca<sup>2+</sup>-Activated K<sup>+</sup> Currents While Inhibiting Voltage-Gated Na<sup>+</sup> Currents

Rufinamide, a Triazole-Derived Antiepileptic Drug, Stimulates Ca<sup>2+</sup>-Activated K<sup>+</sup> Currents While Inhibiting Voltage-Gated Na<sup>+</sup> Currents

Rufinamide (RFM) is a clinically utilized antiepileptic drug that, as a triazole derivative, has a unique structure. The extent to which this drug affects membrane ionic currents remains incompletely understood. With the aid of patch clamp technology, we investigated the effects of RFM on the amplit...

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Bibliographic Details
Main Authors: Ming-Chi Lai, Sheng-Nan Wu, Chin-Wei Huang
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
rufinamide (1-((2,6-difluorophenyl)methyl)-1H-1,2,3-triazole-4carboxamide)
antiepileptic drug
Ca<sup>2+</sup>-activated K<sup>+</sup> current
large-conductance Ca<sup>2+</sup>-activated K<sup>+</sup> channel
hysteresis
voltage-gated Na<sup>+</sup> current
Online Access:https://www.mdpi.com/1422-0067/23/22/13677

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