Topiramate as a neuroprotective agent in a rat model of spinal cord injury
Topiramate (TPM) is a widely used antiepileptic and antimigraine agent which has been shown to exert neuroprotective effects in various experimental traumatic brain injury and stroke models. However, its utility in spinal cord injury has not been studied extensively. Thus, we evaluated effects of TP...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=12;spage=2071;epage=2076;aulast=Narin |
| _version_ | 1828852554217291776 |
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| author | Firat Narin Sahin Hanalioglu Huseyin Ustun Kamer Kilinc Burcak Bilginer |
| author_facet | Firat Narin Sahin Hanalioglu Huseyin Ustun Kamer Kilinc Burcak Bilginer |
| author_sort | Firat Narin |
| collection | DOAJ |
| description | Topiramate (TPM) is a widely used antiepileptic and antimigraine agent which has been shown to exert neuroprotective effects in various experimental traumatic brain injury and stroke models. However, its utility in spinal cord injury has not been studied extensively. Thus, we evaluated effects of TPM on secondary cellular injury mechanisms in an experimental rat model of traumatic spinal cord injury (SCI). After rat models of thoracic contusive SCI were established by free weight-drop method, TPM (40 mg/kg) was given at 12-hour intervals for four times orally. Post TPM treatment, malondialdehyde and protein carbonyl levels were significantly reduced and reduced glutathione levels were increased, while immunoreactivity for endothelial nitric oxide synthase, inducible nitric oxide synthase, and apoptotic peptidase activating factor 1 was diminished in SCI rats. In addition, TPM treatment improved the functional recovery of SCI rats. This study suggests that administration of TPM exerts neuroprotective effects on SCI. |
| first_indexed | 2024-12-12T23:55:36Z |
| format | Article |
| id | doaj.art-d3c8eae88a8f4d0db01942a6c5455c6a |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-12T23:55:36Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-d3c8eae88a8f4d0db01942a6c5455c6a2022-12-22T00:06:35ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742017-01-0112122071207610.4103/1673-5374.221164Topiramate as a neuroprotective agent in a rat model of spinal cord injuryFirat NarinSahin HanaliogluHuseyin UstunKamer KilincBurcak BilginerTopiramate (TPM) is a widely used antiepileptic and antimigraine agent which has been shown to exert neuroprotective effects in various experimental traumatic brain injury and stroke models. However, its utility in spinal cord injury has not been studied extensively. Thus, we evaluated effects of TPM on secondary cellular injury mechanisms in an experimental rat model of traumatic spinal cord injury (SCI). After rat models of thoracic contusive SCI were established by free weight-drop method, TPM (40 mg/kg) was given at 12-hour intervals for four times orally. Post TPM treatment, malondialdehyde and protein carbonyl levels were significantly reduced and reduced glutathione levels were increased, while immunoreactivity for endothelial nitric oxide synthase, inducible nitric oxide synthase, and apoptotic peptidase activating factor 1 was diminished in SCI rats. In addition, TPM treatment improved the functional recovery of SCI rats. This study suggests that administration of TPM exerts neuroprotective effects on SCI.http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=12;spage=2071;epage=2076;aulast=Narinnerve regeneration; spinal cord injury; topiramate; neuroprotection; oxidative damage; nitric oxide; motor function; neural regeneration |
| spellingShingle | Firat Narin Sahin Hanalioglu Huseyin Ustun Kamer Kilinc Burcak Bilginer Topiramate as a neuroprotective agent in a rat model of spinal cord injury Neural Regeneration Research nerve regeneration; spinal cord injury; topiramate; neuroprotection; oxidative damage; nitric oxide; motor function; neural regeneration |
| title | Topiramate as a neuroprotective agent in a rat model of spinal cord injury |
| title_full | Topiramate as a neuroprotective agent in a rat model of spinal cord injury |
| title_fullStr | Topiramate as a neuroprotective agent in a rat model of spinal cord injury |
| title_full_unstemmed | Topiramate as a neuroprotective agent in a rat model of spinal cord injury |
| title_short | Topiramate as a neuroprotective agent in a rat model of spinal cord injury |
| title_sort | topiramate as a neuroprotective agent in a rat model of spinal cord injury |
| topic | nerve regeneration; spinal cord injury; topiramate; neuroprotection; oxidative damage; nitric oxide; motor function; neural regeneration |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=12;spage=2071;epage=2076;aulast=Narin |
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