Astrocytes: Role in pathogenesis and effect of commonly misused drugs in the HIV infected brain
The roles of astrocytes as reservoirs and producers of a subset of viral proteins in the HIV infected brain have been studied extensively as a key to understanding HIV-associated neurocognitive disorders (HAND). However, their comprehensive role in the context of intersecting substance use and neuro...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Current Research in Neurobiology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665945X23000360 |
| _version_ | 1797690889884139520 |
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| author | Jessalyn Pla-Tenorio Angela M. Roig Paulina A. García-Cesaní Luis A. Santiago Marian T. Sepulveda-Orengo Richard J. Noel, Jr. |
| author_facet | Jessalyn Pla-Tenorio Angela M. Roig Paulina A. García-Cesaní Luis A. Santiago Marian T. Sepulveda-Orengo Richard J. Noel, Jr. |
| author_sort | Jessalyn Pla-Tenorio |
| collection | DOAJ |
| description | The roles of astrocytes as reservoirs and producers of a subset of viral proteins in the HIV infected brain have been studied extensively as a key to understanding HIV-associated neurocognitive disorders (HAND). However, their comprehensive role in the context of intersecting substance use and neurocircuitry of the reward pathway and HAND has yet to be fully explained. Use of methamphetamines, cocaine, or opioids in the context of HIV infection have been shown to lead to a faster progression of HAND. Glutamatergic, dopaminergic, and GABAergic systems are implicated in the development of HAND-induced cognitive impairments. A thorough review of scientific literature exploring the variety of mechanisms in which these drugs exert their effects on the HIV brain and astrocytes has revealed marked areas of convergence in overexcitation leading to increased drug-seeking behavior, inflammation, apoptosis, and irreversible neurotoxicity. The present review investigates astrocytes, the neural pathways, and mechanisms of drug disruption that ultimately play a larger holistic role in terms of HIV progression and drug use. There are opportunities for future research, therapeutic intervention, and preventive strategies to diminish HAND in the subset population of patients with HIV and substance use disorder. |
| first_indexed | 2024-03-12T02:06:35Z |
| format | Article |
| id | doaj.art-d3c9892ac62a492ebca823ad730b4b75 |
| institution | Directory Open Access Journal |
| issn | 2665-945X |
| language | English |
| last_indexed | 2024-03-12T02:06:35Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Neurobiology |
| spelling | doaj.art-d3c9892ac62a492ebca823ad730b4b752023-09-07T04:44:46ZengElsevierCurrent Research in Neurobiology2665-945X2023-01-015100108Astrocytes: Role in pathogenesis and effect of commonly misused drugs in the HIV infected brainJessalyn Pla-Tenorio0Angela M. Roig1Paulina A. García-Cesaní2Luis A. Santiago3Marian T. Sepulveda-Orengo4Richard J. Noel, Jr.5Seattle Children's Hospital, MS OC.7.830, 4800 Sand Point Way NE, Seattle, WA, 98105-0371, United States; Bella Vista Hospital, Family Medicine Residency, Carr. 349 Km 2.7, Cerro Las Mesas, Mayaguez, PR, 00681, Puerto Rico; Ponce Health Sciences University, School of Medicine, Department of Basic Sciences, 395 Industrial Reparada, Zona 2, Ponce, PR, 00716, Puerto RicoSeattle Children's Hospital, MS OC.7.830, 4800 Sand Point Way NE, Seattle, WA, 98105-0371, United States; Bella Vista Hospital, Family Medicine Residency, Carr. 349 Km 2.7, Cerro Las Mesas, Mayaguez, PR, 00681, Puerto Rico; Ponce Health Sciences University, School of Medicine, Department of Basic Sciences, 395 Industrial Reparada, Zona 2, Ponce, PR, 00716, Puerto RicoSeattle Children's Hospital, MS OC.7.830, 4800 Sand Point Way NE, Seattle, WA, 98105-0371, United States; Bella Vista Hospital, Family Medicine Residency, Carr. 349 Km 2.7, Cerro Las Mesas, Mayaguez, PR, 00681, Puerto Rico; Ponce Health Sciences University, School of Medicine, Department of Basic Sciences, 395 Industrial Reparada, Zona 2, Ponce, PR, 00716, Puerto RicoSeattle Children's Hospital, MS OC.7.830, 4800 Sand Point Way NE, Seattle, WA, 98105-0371, United States; Bella Vista Hospital, Family Medicine Residency, Carr. 349 Km 2.7, Cerro Las Mesas, Mayaguez, PR, 00681, Puerto Rico; Ponce Health Sciences University, School of Medicine, Department of Basic Sciences, 395 Industrial Reparada, Zona 2, Ponce, PR, 00716, Puerto RicoSeattle Children's Hospital, MS OC.7.830, 4800 Sand Point Way NE, Seattle, WA, 98105-0371, United States; Bella Vista Hospital, Family Medicine Residency, Carr. 349 Km 2.7, Cerro Las Mesas, Mayaguez, PR, 00681, Puerto Rico; Ponce Health Sciences University, School of Medicine, Department of Basic Sciences, 395 Industrial Reparada, Zona 2, Ponce, PR, 00716, Puerto RicoCorresponding author. Ponce Health Sciences University School of Medicine, Department of Basic Sciences 395 Industrial Reparada, Zona 2, Ponce, PR, 00716, Puerto Rico.; Seattle Children's Hospital, MS OC.7.830, 4800 Sand Point Way NE, Seattle, WA, 98105-0371, United States; Bella Vista Hospital, Family Medicine Residency, Carr. 349 Km 2.7, Cerro Las Mesas, Mayaguez, PR, 00681, Puerto Rico; Ponce Health Sciences University, School of Medicine, Department of Basic Sciences, 395 Industrial Reparada, Zona 2, Ponce, PR, 00716, Puerto RicoThe roles of astrocytes as reservoirs and producers of a subset of viral proteins in the HIV infected brain have been studied extensively as a key to understanding HIV-associated neurocognitive disorders (HAND). However, their comprehensive role in the context of intersecting substance use and neurocircuitry of the reward pathway and HAND has yet to be fully explained. Use of methamphetamines, cocaine, or opioids in the context of HIV infection have been shown to lead to a faster progression of HAND. Glutamatergic, dopaminergic, and GABAergic systems are implicated in the development of HAND-induced cognitive impairments. A thorough review of scientific literature exploring the variety of mechanisms in which these drugs exert their effects on the HIV brain and astrocytes has revealed marked areas of convergence in overexcitation leading to increased drug-seeking behavior, inflammation, apoptosis, and irreversible neurotoxicity. The present review investigates astrocytes, the neural pathways, and mechanisms of drug disruption that ultimately play a larger holistic role in terms of HIV progression and drug use. There are opportunities for future research, therapeutic intervention, and preventive strategies to diminish HAND in the subset population of patients with HIV and substance use disorder.http://www.sciencedirect.com/science/article/pii/S2665945X23000360AstrocyteHIVSubstance use disorderNeurotransmitter |
| spellingShingle | Jessalyn Pla-Tenorio Angela M. Roig Paulina A. García-Cesaní Luis A. Santiago Marian T. Sepulveda-Orengo Richard J. Noel, Jr. Astrocytes: Role in pathogenesis and effect of commonly misused drugs in the HIV infected brain Current Research in Neurobiology Astrocyte HIV Substance use disorder Neurotransmitter |
| title | Astrocytes: Role in pathogenesis and effect of commonly misused drugs in the HIV infected brain |
| title_full | Astrocytes: Role in pathogenesis and effect of commonly misused drugs in the HIV infected brain |
| title_fullStr | Astrocytes: Role in pathogenesis and effect of commonly misused drugs in the HIV infected brain |
| title_full_unstemmed | Astrocytes: Role in pathogenesis and effect of commonly misused drugs in the HIV infected brain |
| title_short | Astrocytes: Role in pathogenesis and effect of commonly misused drugs in the HIV infected brain |
| title_sort | astrocytes role in pathogenesis and effect of commonly misused drugs in the hiv infected brain |
| topic | Astrocyte HIV Substance use disorder Neurotransmitter |
| url | http://www.sciencedirect.com/science/article/pii/S2665945X23000360 |
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