URAT1 is expressed in cardiomyocytes and dotinurad attenuates the development of diet-induced metabolic heart disease

URAT1 is expressed in cardiomyocytes and dotinurad attenuates the development of diet-induced metabolic heart disease

Summary: We recently reported that the selective inhibition of urate transporter-1 (URAT1), which is primarily expressed in the kidneys, ameliorates insulin resistance by attenuating hepatic steatosis and improving brown adipose tissue function in diet-induced obesity. In this study, we evaluated th...

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Bibliographic Details
Main Authors: Yoshiro Tanaka, Tomohisa Nagoshi, Hirotake Takahashi, Yuhei Oi, Rei Yasutake, Akira Yoshii, Haruka Kimura, Yusuke Kashiwagi, Toshikazu D. Tanaka, Masayuki Shimoda, Michihiro Yoshimura
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:iScience
Subjects:
Cell biology
Pathophysiology
Physiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223018072

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