Case report and literature review: plexiform schwannoma in the penile and inguinal region in a child
Penile schwannoma is an uncommonly seen peripheral nerve tumor, of which penile plexiform schwannomas (PS) is extremely rare that has only been reported in several adults. We present a case of penile PS with a similar lesion in inguinal region in a 9-year-old child, which appeared as painless masses...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1356000/full |
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| author | Xiaoying Qi Xiaoying Qi Yifei Tan Yifei Tan Yanru Feng Dan Ma Ling Wang Ling Wang Houqing Pang Houqing Pang |
| author_facet | Xiaoying Qi Xiaoying Qi Yifei Tan Yifei Tan Yanru Feng Dan Ma Ling Wang Ling Wang Houqing Pang Houqing Pang |
| author_sort | Xiaoying Qi |
| collection | DOAJ |
| description | Penile schwannoma is an uncommonly seen peripheral nerve tumor, of which penile plexiform schwannomas (PS) is extremely rare that has only been reported in several adults. We present a case of penile PS with a similar lesion in inguinal region in a 9-year-old child, which appeared as painless masses and rapidly growing within one year. Penile ultrasonography suggested well-defined lesions with limited vascularity. Both masses presented with low-to-intermediated signal intensity and no definite enhancement in computed tomography. The lesions were completely resected with minimal intraoperative bleeding, and a diagnose of benign PS was confirmed based on H&E staining and positive S-100 expression in immunohistochemistry. There was no evidence of tumor recurrence or metastasis after 6 months of follow-up. Only 6 cases of penile schwannoma in children were recorded, of which 5 were malignant, and none was PS. The malignancy rate of penile schwannoma in children may be overestimated due to delayed diagnose of benign ones. A rapidly growing penile mass with a suspected metastatic lesion in inguinal region could be easily misdiagnosed as malignant. This case report and literature review is expected to assist clinicians in getting a comprehensive understanding of children penile schwannomas and choosing the best management strategy when faced with this rare condition. |
| first_indexed | 2024-03-07T19:10:46Z |
| format | Article |
| id | doaj.art-d3cbf60a1fb24b39b63a9723b0b220cc |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-07T19:10:46Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-d3cbf60a1fb24b39b63a9723b0b220cc2024-03-01T04:37:35ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-03-011410.3389/fonc.2024.13560001356000Case report and literature review: plexiform schwannoma in the penile and inguinal region in a childXiaoying Qi0Xiaoying Qi1Yifei Tan2Yifei Tan3Yanru Feng4Dan Ma5Ling Wang6Ling Wang7Houqing Pang8Houqing Pang9Department of Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Ultrasound, Meishan Women and Childrens’ Hospital, Alliance Hospital of West China Second University Hospital, Sichuan University, Meishan, Sichuan, ChinaDepartment of Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaPenile schwannoma is an uncommonly seen peripheral nerve tumor, of which penile plexiform schwannomas (PS) is extremely rare that has only been reported in several adults. We present a case of penile PS with a similar lesion in inguinal region in a 9-year-old child, which appeared as painless masses and rapidly growing within one year. Penile ultrasonography suggested well-defined lesions with limited vascularity. Both masses presented with low-to-intermediated signal intensity and no definite enhancement in computed tomography. The lesions were completely resected with minimal intraoperative bleeding, and a diagnose of benign PS was confirmed based on H&E staining and positive S-100 expression in immunohistochemistry. There was no evidence of tumor recurrence or metastasis after 6 months of follow-up. Only 6 cases of penile schwannoma in children were recorded, of which 5 were malignant, and none was PS. The malignancy rate of penile schwannoma in children may be overestimated due to delayed diagnose of benign ones. A rapidly growing penile mass with a suspected metastatic lesion in inguinal region could be easily misdiagnosed as malignant. This case report and literature review is expected to assist clinicians in getting a comprehensive understanding of children penile schwannomas and choosing the best management strategy when faced with this rare condition.https://www.frontiersin.org/articles/10.3389/fonc.2024.1356000/fullschwannomapenisinguinal regionplexiformchildren |
| spellingShingle | Xiaoying Qi Xiaoying Qi Yifei Tan Yifei Tan Yanru Feng Dan Ma Ling Wang Ling Wang Houqing Pang Houqing Pang Case report and literature review: plexiform schwannoma in the penile and inguinal region in a child Frontiers in Oncology schwannoma penis inguinal region plexiform children |
| title | Case report and literature review: plexiform schwannoma in the penile and inguinal region in a child |
| title_full | Case report and literature review: plexiform schwannoma in the penile and inguinal region in a child |
| title_fullStr | Case report and literature review: plexiform schwannoma in the penile and inguinal region in a child |
| title_full_unstemmed | Case report and literature review: plexiform schwannoma in the penile and inguinal region in a child |
| title_short | Case report and literature review: plexiform schwannoma in the penile and inguinal region in a child |
| title_sort | case report and literature review plexiform schwannoma in the penile and inguinal region in a child |
| topic | schwannoma penis inguinal region plexiform children |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1356000/full |
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