Incidence and morphology of secondary TDP-43 proteinopathies: Part 2
Transactivation (TAR) DNA binding protein 43 kDa (TDP-43) inclusions frequently occur as a comorbid pathology in several neurodegenerative disorders, including Alzheimer’s disease, Huntington’s disease, Lewy body disease, and progressive supranuclear palsy, and may appear in association with nondege...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2023-07-01
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| Series: | Folia Neuropathologica |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Incidence-and-morphology-of-secondary-TDP-43-proteinopathies-Part-2,20,50873,1,1.html |
| _version_ | 1797692421178392576 |
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| author | Albert Acewicz Tomasz Stępień Paulina Felczak Sylwia Tarka Teresa Wierzba-Bobrowicz |
| author_facet | Albert Acewicz Tomasz Stępień Paulina Felczak Sylwia Tarka Teresa Wierzba-Bobrowicz |
| author_sort | Albert Acewicz |
| collection | DOAJ |
| description | Transactivation (TAR) DNA binding protein 43 kDa (TDP-43) inclusions frequently occur as a comorbid pathology in several neurodegenerative disorders, including Alzheimer’s disease, Huntington’s disease, Lewy body disease, and progressive supranuclear palsy, and may appear in association with nondegenerative neurological etiology, for example neoplastic, paraneoplastic, traumatic, or infectious. Relationships between various pathological proteins and mechanisms associated with TDP-43-induced neurodegeneration are still not fully understood. Thus, overlap of distinct neuropathological mechanisms frequently leads to greater brain atrophy and a more severe clinical course, suggesting the importance of co-pathologies in ante-mortem diagnosing and treatment. The present review aims to discuss the incidence, morphology, and role of TDP-43 pathology in the context of other dominant, hallmark pathologies, referred to as secondary TDP-43 proteinopathies. The previous part (Part 1) focused on common neurodegenerative diseases, including Alzheimer’s disease, Huntington’s disease, and Lewy body disease, while the present part (Part 2) discusses TDP-43 pathology in rare neurodegenerative diseases and neurological diseases with nondegenerative etiology. |
| first_indexed | 2024-03-12T02:27:23Z |
| format | Article |
| id | doaj.art-d3ccd97912864f988ffde66fbb2a44c5 |
| institution | Directory Open Access Journal |
| issn | 1641-4640 1509-572X |
| language | English |
| last_indexed | 2024-03-12T02:27:23Z |
| publishDate | 2023-07-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Folia Neuropathologica |
| spelling | doaj.art-d3ccd97912864f988ffde66fbb2a44c52023-09-05T11:43:19ZengTermedia Publishing HouseFolia Neuropathologica1641-46401509-572X2023-07-0161211112010.5114/fn.2023.12877650873Incidence and morphology of secondary TDP-43 proteinopathies: Part 2Albert AcewiczTomasz StępieńPaulina FelczakSylwia TarkaTeresa Wierzba-BobrowiczTransactivation (TAR) DNA binding protein 43 kDa (TDP-43) inclusions frequently occur as a comorbid pathology in several neurodegenerative disorders, including Alzheimer’s disease, Huntington’s disease, Lewy body disease, and progressive supranuclear palsy, and may appear in association with nondegenerative neurological etiology, for example neoplastic, paraneoplastic, traumatic, or infectious. Relationships between various pathological proteins and mechanisms associated with TDP-43-induced neurodegeneration are still not fully understood. Thus, overlap of distinct neuropathological mechanisms frequently leads to greater brain atrophy and a more severe clinical course, suggesting the importance of co-pathologies in ante-mortem diagnosing and treatment. The present review aims to discuss the incidence, morphology, and role of TDP-43 pathology in the context of other dominant, hallmark pathologies, referred to as secondary TDP-43 proteinopathies. The previous part (Part 1) focused on common neurodegenerative diseases, including Alzheimer’s disease, Huntington’s disease, and Lewy body disease, while the present part (Part 2) discusses TDP-43 pathology in rare neurodegenerative diseases and neurological diseases with nondegenerative etiology.https://www.termedia.pl/Incidence-and-morphology-of-secondary-TDP-43-proteinopathies-Part-2,20,50873,1,1.htmltdp-43 pathology proteinopathy neurodegenerative morphology incidence comorbidity |
| spellingShingle | Albert Acewicz Tomasz Stępień Paulina Felczak Sylwia Tarka Teresa Wierzba-Bobrowicz Incidence and morphology of secondary TDP-43 proteinopathies: Part 2 Folia Neuropathologica tdp-43 pathology proteinopathy neurodegenerative morphology incidence comorbidity |
| title | Incidence and morphology of secondary TDP-43 proteinopathies: Part 2 |
| title_full | Incidence and morphology of secondary TDP-43 proteinopathies: Part 2 |
| title_fullStr | Incidence and morphology of secondary TDP-43 proteinopathies: Part 2 |
| title_full_unstemmed | Incidence and morphology of secondary TDP-43 proteinopathies: Part 2 |
| title_short | Incidence and morphology of secondary TDP-43 proteinopathies: Part 2 |
| title_sort | incidence and morphology of secondary tdp 43 proteinopathies part 2 |
| topic | tdp-43 pathology proteinopathy neurodegenerative morphology incidence comorbidity |
| url | https://www.termedia.pl/Incidence-and-morphology-of-secondary-TDP-43-proteinopathies-Part-2,20,50873,1,1.html |
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