Blood virome of patients with traumatic sepsis
Abstract Sepsis is one of the possible outcomes of severe trauma, and it poses a dire threat to human life, particularly in immunocompromised people. The most prevalent pathogens are bacteria and fungi, but viruses should not be overlooked. For viral metagenomic analysis, we collected blood samples...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Virology Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12985-023-02162-4 |
| _version_ | 1827724653085327360 |
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| author | Qingqing Mao Ying Liu Ju Zhang Wang Li Wen Zhang Chenglin Zhou |
| author_facet | Qingqing Mao Ying Liu Ju Zhang Wang Li Wen Zhang Chenglin Zhou |
| author_sort | Qingqing Mao |
| collection | DOAJ |
| description | Abstract Sepsis is one of the possible outcomes of severe trauma, and it poses a dire threat to human life, particularly in immunocompromised people. The most prevalent pathogens are bacteria and fungi, but viruses should not be overlooked. For viral metagenomic analysis, we collected blood samples from eight patients with post-traumatic sepsis before and seven days after treatment. The results demonstrated that Anellovirus predominated the viral community, followed by Siphoviridae and Myoviridae, and that the variations in viral community and viral load before and after treatment were not statistically significant. This study allows us to investigate methods for establishing NGS-based viral diagnostic instruments for detecting viral infections in the blood of sepsis patients so that antiviral therapy can be administered quickly. |
| first_indexed | 2024-03-10T22:18:46Z |
| format | Article |
| id | doaj.art-d3cd949b4d9141e1afdbe93086966c14 |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-03-10T22:18:46Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-d3cd949b4d9141e1afdbe93086966c142023-11-19T12:21:39ZengBMCVirology Journal1743-422X2023-09-012011610.1186/s12985-023-02162-4Blood virome of patients with traumatic sepsisQingqing Mao0Ying Liu1Ju Zhang2Wang Li3Wen Zhang4Chenglin Zhou5Clinical Laboratory Center, The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityClinical Laboratory Center, Xuzhou Central HospitalDepartment of Laboratory Medicine, School of Medicine, Jiangsu UniversityClinical Laboratory Center, The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityDepartment of Laboratory Medicine, School of Medicine, Jiangsu UniversityClinical Laboratory Center, The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityAbstract Sepsis is one of the possible outcomes of severe trauma, and it poses a dire threat to human life, particularly in immunocompromised people. The most prevalent pathogens are bacteria and fungi, but viruses should not be overlooked. For viral metagenomic analysis, we collected blood samples from eight patients with post-traumatic sepsis before and seven days after treatment. The results demonstrated that Anellovirus predominated the viral community, followed by Siphoviridae and Myoviridae, and that the variations in viral community and viral load before and after treatment were not statistically significant. This study allows us to investigate methods for establishing NGS-based viral diagnostic instruments for detecting viral infections in the blood of sepsis patients so that antiviral therapy can be administered quickly.https://doi.org/10.1186/s12985-023-02162-4SepsisWounds and injuriesMategenomicsBloodVirome |
| spellingShingle | Qingqing Mao Ying Liu Ju Zhang Wang Li Wen Zhang Chenglin Zhou Blood virome of patients with traumatic sepsis Virology Journal Sepsis Wounds and injuries Mategenomics Blood Virome |
| title | Blood virome of patients with traumatic sepsis |
| title_full | Blood virome of patients with traumatic sepsis |
| title_fullStr | Blood virome of patients with traumatic sepsis |
| title_full_unstemmed | Blood virome of patients with traumatic sepsis |
| title_short | Blood virome of patients with traumatic sepsis |
| title_sort | blood virome of patients with traumatic sepsis |
| topic | Sepsis Wounds and injuries Mategenomics Blood Virome |
| url | https://doi.org/10.1186/s12985-023-02162-4 |
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