In vivo nephroprotective efficacy of propolis against contrast-induced nephropathy
PURPOSEContrast agents administered in diagnostic imaging or interventional procedures of clinical radiology may cause contrast-induced nephropathy (CIN). Preventive measures against CIN involve pharmaceutical pretreatments, such as N-acetylcystein (NAC) or calpain, but alternative medicines can als...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2015-07-01
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| Series: | Diagnostic and Interventional Radiology |
| Online Access: |
http://www.dirjournal.org/archives/archive-detail/article-preview/n-vivo-nephroprotective-efficacy-of-propolis-again/55745
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| _version_ | 1797691242449993728 |
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| author | Murat Baykara Sibel Silici Mehtap Özçelik Osman Güler Nuri Erdoğan Mehmet Bilgen |
| author_facet | Murat Baykara Sibel Silici Mehtap Özçelik Osman Güler Nuri Erdoğan Mehmet Bilgen |
| author_sort | Murat Baykara |
| collection | DOAJ |
| description | PURPOSEContrast agents administered in diagnostic imaging or interventional procedures of clinical radiology may cause contrast-induced nephropathy (CIN). Preventive measures against CIN involve pharmaceutical pretreatments, such as N-acetylcystein (NAC) or calpain, but alternative medicines can also be helpful. This study aims to assess the prospects of a natural compound, propolis, as a potential nephroprotector against a specific contrast agent, diatrizoate.METHODSIn vivo experiments were performed on 35 male rats in five groups: control, diatrizoate alone, and pretreatments with propolis, NAC, or calpain one hour before diatrizoate administration. Three days later, blood and renal tissue samples were collected and quantitatively processed for determining induced changes in critical biomarkers malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT), as well as serum creatinine and plasma urea.RESULTSDiatrizoate increased creatinine (113%), urea (400%), and MDA (162%) levels and decreased GSH (-71%), SOD (-69%), GSH-Px (-77%), and CAT (-73%) levels. Evaluating the response of each pretreatment provided sufficient evidence that propolis was as effective as either NAC or calpain, but consistently more prominent in restoring the MDA, GSH, SOD, and GSH-Px levels close to their normal range. This outcome demonstrated the nephroprotective effect of propolis against CIN.CONCLUSIONPropolis protects renal tissue against toxicity, free radicals, and other adverse effects induced by diatrizoate. This function is most likely exerted through the antioxidant and antitoxic activities of propolis. |
| first_indexed | 2024-03-12T02:10:33Z |
| format | Article |
| id | doaj.art-d3ce1c7abd43408eac0f74316f5f2d75 |
| institution | Directory Open Access Journal |
| issn | 1305-3825 1305-3612 |
| language | English |
| last_indexed | 2024-03-12T02:10:33Z |
| publishDate | 2015-07-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Diagnostic and Interventional Radiology |
| spelling | doaj.art-d3ce1c7abd43408eac0f74316f5f2d752023-09-06T13:47:26ZengGalenos Publishing HouseDiagnostic and Interventional Radiology1305-38251305-36122015-07-0121431732110.5152/dir.2015.1407513049054In vivo nephroprotective efficacy of propolis against contrast-induced nephropathyMurat Baykara0Sibel Silici1Mehtap Özçelik2Osman Güler3Nuri Erdoğan4Mehmet Bilgen5 Department of Radiology, Sütçü İmam University School of Medicine, Kahramanmaraş, Turkey Department of Agricultural Biotechnology, Erciyes University Agriculture Faculty, Kayseri, Turkey Elazığ Veterinary Control and Research Institute, Elazığ, Turkey Elazığ Veterinary Control and Research Institute, Elazığ, Turkey Department of Radiology, Tepecik Training and Research Hospital, İzmir, Turkey Department of Biophysics, Adnan Menderes University School of Medicine, Aydın, Turkey PURPOSEContrast agents administered in diagnostic imaging or interventional procedures of clinical radiology may cause contrast-induced nephropathy (CIN). Preventive measures against CIN involve pharmaceutical pretreatments, such as N-acetylcystein (NAC) or calpain, but alternative medicines can also be helpful. This study aims to assess the prospects of a natural compound, propolis, as a potential nephroprotector against a specific contrast agent, diatrizoate.METHODSIn vivo experiments were performed on 35 male rats in five groups: control, diatrizoate alone, and pretreatments with propolis, NAC, or calpain one hour before diatrizoate administration. Three days later, blood and renal tissue samples were collected and quantitatively processed for determining induced changes in critical biomarkers malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT), as well as serum creatinine and plasma urea.RESULTSDiatrizoate increased creatinine (113%), urea (400%), and MDA (162%) levels and decreased GSH (-71%), SOD (-69%), GSH-Px (-77%), and CAT (-73%) levels. Evaluating the response of each pretreatment provided sufficient evidence that propolis was as effective as either NAC or calpain, but consistently more prominent in restoring the MDA, GSH, SOD, and GSH-Px levels close to their normal range. This outcome demonstrated the nephroprotective effect of propolis against CIN.CONCLUSIONPropolis protects renal tissue against toxicity, free radicals, and other adverse effects induced by diatrizoate. This function is most likely exerted through the antioxidant and antitoxic activities of propolis. http://www.dirjournal.org/archives/archive-detail/article-preview/n-vivo-nephroprotective-efficacy-of-propolis-again/55745 |
| spellingShingle | Murat Baykara Sibel Silici Mehtap Özçelik Osman Güler Nuri Erdoğan Mehmet Bilgen In vivo nephroprotective efficacy of propolis against contrast-induced nephropathy Diagnostic and Interventional Radiology |
| title | In vivo nephroprotective efficacy of propolis against contrast-induced nephropathy |
| title_full | In vivo nephroprotective efficacy of propolis against contrast-induced nephropathy |
| title_fullStr | In vivo nephroprotective efficacy of propolis against contrast-induced nephropathy |
| title_full_unstemmed | In vivo nephroprotective efficacy of propolis against contrast-induced nephropathy |
| title_short | In vivo nephroprotective efficacy of propolis against contrast-induced nephropathy |
| title_sort | in vivo nephroprotective efficacy of propolis against contrast induced nephropathy |
| url |
http://www.dirjournal.org/archives/archive-detail/article-preview/n-vivo-nephroprotective-efficacy-of-propolis-again/55745
|
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