Burn Wound Healing Effect of a Sterilized Traditional Formulation of Boswellia carteri vs. Silver Sulfadiazine Cream 1% in Patients Presenting Second-degree Burn Wounds: A Randomized, Double-blind Clinical Trial
Background: Burn wounds rank among the most serious healthcare issues. Many studies reported the effectiveness of natural products in the wound-healing process. The present study compared the effects of a standardized herbal formulation derived from Boswellia carteri (B. carteri) and silver sulfadia...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2023-03-01
|
| Series: | Iranian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://ijms.sums.ac.ir/article_48728_ecd423eaff904be84476522b3dbb3fa2.pdf |
| _version_ | 1811154676001800192 |
|---|---|
| author | Parmis Badr Suleiman Afsharypuor Hamid Reza Tohidinik Ali Akbar Mohammadi Saeid Daneshamouz |
| author_facet | Parmis Badr Suleiman Afsharypuor Hamid Reza Tohidinik Ali Akbar Mohammadi Saeid Daneshamouz |
| author_sort | Parmis Badr |
| collection | DOAJ |
| description | Background: Burn wounds rank among the most serious healthcare issues. Many studies reported the effectiveness of natural products in the wound-healing process. The present study compared the effects of a standardized herbal formulation derived from Boswellia carteri (B. carteri) and silver sulfadiazine (SSD) cream 1% on the healing of burn wounds.Methods: This randomized double-blind clinical trial was conducted at Shiraz Burn Hospital (Shiraz, Iran) between July 2012 to August 2013. A sterilized formulation comprising B. carteri 40% was prepared. 54 second-degree burn patients of both sexes with age ranges of 20 to 60 were invited to participate in this double-blind, randomized clinical trial. They were randomly divided into two groups and given either the Boswellia formulation or SSD cream. The healing index was determined based on the wound area assessment using the planimetry technique. The Kaplan-Meier survival analysis was used to assess the primary outcome, which was the amount of time until complete healing.Results: The trial was completed by 17 patients from the SSD group and 15 patients from the Boswellia group. During the study period, both groups showed a progressive healing trend. The mean (95% CI) healing time in the SSD group was 10.94 (9.03-12.85) days and 10.73 (9.23-12.23) days in the Boswellia group (P=0.71), indicating no significant difference. On the 17th day, the healing index of all patients in the Boswellia group reached 1.Conclusion: Boswellia topical formulation had a burn wound healing effect comparable to that of the standard SSD 1% treatment. Based on the findings of this study, the likelihood of contact dermatitis with Boswellia should be taken into consideration. |
| first_indexed | 2024-04-10T04:21:07Z |
| format | Article |
| id | doaj.art-d3cfb7cab2eb463b9c00d82d048c2a2f |
| institution | Directory Open Access Journal |
| issn | 0253-0716 1735-3688 |
| language | English |
| last_indexed | 2024-04-10T04:21:07Z |
| publishDate | 2023-03-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Medical Sciences |
| spelling | doaj.art-d3cfb7cab2eb463b9c00d82d048c2a2f2023-03-11T06:28:56ZengShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-07161735-36882023-03-0148213714510.30476/ijms.2022.91853.230748728Burn Wound Healing Effect of a Sterilized Traditional Formulation of Boswellia carteri vs. Silver Sulfadiazine Cream 1% in Patients Presenting Second-degree Burn Wounds: A Randomized, Double-blind Clinical TrialParmis Badr0Suleiman Afsharypuor1Hamid Reza Tohidinik2Ali Akbar Mohammadi3Saeid Daneshamouz4Pharmaceutical Science Research Center, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pharmacognosy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, IranCentre for Academic Child Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United KingdomBurn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IranBackground: Burn wounds rank among the most serious healthcare issues. Many studies reported the effectiveness of natural products in the wound-healing process. The present study compared the effects of a standardized herbal formulation derived from Boswellia carteri (B. carteri) and silver sulfadiazine (SSD) cream 1% on the healing of burn wounds.Methods: This randomized double-blind clinical trial was conducted at Shiraz Burn Hospital (Shiraz, Iran) between July 2012 to August 2013. A sterilized formulation comprising B. carteri 40% was prepared. 54 second-degree burn patients of both sexes with age ranges of 20 to 60 were invited to participate in this double-blind, randomized clinical trial. They were randomly divided into two groups and given either the Boswellia formulation or SSD cream. The healing index was determined based on the wound area assessment using the planimetry technique. The Kaplan-Meier survival analysis was used to assess the primary outcome, which was the amount of time until complete healing.Results: The trial was completed by 17 patients from the SSD group and 15 patients from the Boswellia group. During the study period, both groups showed a progressive healing trend. The mean (95% CI) healing time in the SSD group was 10.94 (9.03-12.85) days and 10.73 (9.23-12.23) days in the Boswellia group (P=0.71), indicating no significant difference. On the 17th day, the healing index of all patients in the Boswellia group reached 1.Conclusion: Boswellia topical formulation had a burn wound healing effect comparable to that of the standard SSD 1% treatment. Based on the findings of this study, the likelihood of contact dermatitis with Boswellia should be taken into consideration.https://ijms.sums.ac.ir/article_48728_ecd423eaff904be84476522b3dbb3fa2.pdfboswelliaburnswound healingclinical trialmedicine, traditional |
| spellingShingle | Parmis Badr Suleiman Afsharypuor Hamid Reza Tohidinik Ali Akbar Mohammadi Saeid Daneshamouz Burn Wound Healing Effect of a Sterilized Traditional Formulation of Boswellia carteri vs. Silver Sulfadiazine Cream 1% in Patients Presenting Second-degree Burn Wounds: A Randomized, Double-blind Clinical Trial Iranian Journal of Medical Sciences boswellia burns wound healing clinical trial medicine, traditional |
| title | Burn Wound Healing Effect of a Sterilized Traditional Formulation of Boswellia carteri vs. Silver Sulfadiazine Cream 1% in Patients Presenting Second-degree Burn Wounds: A Randomized, Double-blind Clinical Trial |
| title_full | Burn Wound Healing Effect of a Sterilized Traditional Formulation of Boswellia carteri vs. Silver Sulfadiazine Cream 1% in Patients Presenting Second-degree Burn Wounds: A Randomized, Double-blind Clinical Trial |
| title_fullStr | Burn Wound Healing Effect of a Sterilized Traditional Formulation of Boswellia carteri vs. Silver Sulfadiazine Cream 1% in Patients Presenting Second-degree Burn Wounds: A Randomized, Double-blind Clinical Trial |
| title_full_unstemmed | Burn Wound Healing Effect of a Sterilized Traditional Formulation of Boswellia carteri vs. Silver Sulfadiazine Cream 1% in Patients Presenting Second-degree Burn Wounds: A Randomized, Double-blind Clinical Trial |
| title_short | Burn Wound Healing Effect of a Sterilized Traditional Formulation of Boswellia carteri vs. Silver Sulfadiazine Cream 1% in Patients Presenting Second-degree Burn Wounds: A Randomized, Double-blind Clinical Trial |
| title_sort | burn wound healing effect of a sterilized traditional formulation of boswellia carteri vs silver sulfadiazine cream 1 in patients presenting second degree burn wounds a randomized double blind clinical trial |
| topic | boswellia burns wound healing clinical trial medicine, traditional |
| url | https://ijms.sums.ac.ir/article_48728_ecd423eaff904be84476522b3dbb3fa2.pdf |
| work_keys_str_mv | AT parmisbadr burnwoundhealingeffectofasterilizedtraditionalformulationofboswelliacarterivssilversulfadiazinecream1inpatientspresentingseconddegreeburnwoundsarandomizeddoubleblindclinicaltrial AT suleimanafsharypuor burnwoundhealingeffectofasterilizedtraditionalformulationofboswelliacarterivssilversulfadiazinecream1inpatientspresentingseconddegreeburnwoundsarandomizeddoubleblindclinicaltrial AT hamidrezatohidinik burnwoundhealingeffectofasterilizedtraditionalformulationofboswelliacarterivssilversulfadiazinecream1inpatientspresentingseconddegreeburnwoundsarandomizeddoubleblindclinicaltrial AT aliakbarmohammadi burnwoundhealingeffectofasterilizedtraditionalformulationofboswelliacarterivssilversulfadiazinecream1inpatientspresentingseconddegreeburnwoundsarandomizeddoubleblindclinicaltrial AT saeiddaneshamouz burnwoundhealingeffectofasterilizedtraditionalformulationofboswelliacarterivssilversulfadiazinecream1inpatientspresentingseconddegreeburnwoundsarandomizeddoubleblindclinicaltrial |