Role of Sphingosine Kinase in Type 2 Diabetes Mellitus
Sphingolipids are a class of essential lipids, functioning as both cell membrane constituents and signaling messengers. In the sphingolipid metabolic network, ceramides serve as the central hub that is hydrolyzed to sphingosine, followed by phosphorylation to sphingosine 1-phosphate (S1P) by sphingo...
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| Format: | Article |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2020.627076/full |
| _version_ | 1818612722708774912 |
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| author | Yanfei Qi Wei Wang Ziyu Song Gulibositan Aji Xin Tracy Liu Pu Xia |
| author_facet | Yanfei Qi Wei Wang Ziyu Song Gulibositan Aji Xin Tracy Liu Pu Xia |
| author_sort | Yanfei Qi |
| collection | DOAJ |
| description | Sphingolipids are a class of essential lipids, functioning as both cell membrane constituents and signaling messengers. In the sphingolipid metabolic network, ceramides serve as the central hub that is hydrolyzed to sphingosine, followed by phosphorylation to sphingosine 1-phosphate (S1P) by sphingosine kinase (SphK). SphK is regarded as a “switch” of the sphingolipid rheostat, as it catalyzes the conversion of ceramide/sphingosine to S1P, which often exhibit opposing biological roles in the cell. Besides, SphK is an important signaling enzyme that has been implicated in the regulation of a wide variety of biological functions. In recent years, an increasing body of evidence has suggested a critical role of SphK in type 2 diabetes mellitus (T2D), although a certain level of controversy remains. Herein, we review recent findings related to SphK in the field of T2D research with a focus on peripheral insulin resistance and pancreatic β-cell failure. It is expected that a comprehensive understanding of the role of SphK and the associated sphingolipids in T2D will help to identify druggable targets for future anti-diabetes therapy. |
| first_indexed | 2024-12-16T15:50:45Z |
| format | Article |
| id | doaj.art-d3d012903c1c40d0abedfb2af52e5e3a |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-16T15:50:45Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-d3d012903c1c40d0abedfb2af52e5e3a2022-12-21T22:25:42ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-02-011110.3389/fendo.2020.627076627076Role of Sphingosine Kinase in Type 2 Diabetes MellitusYanfei Qi0Wei Wang1Ziyu Song2Gulibositan Aji3Xin Tracy Liu4Pu Xia5Lipid Cell Biology Laboratory, Centenary Institute of Cancer Medicine and Cell Biology, University of Sydney, Sydney, NSW, AustraliaDepartment of Endocrinology and Metabolism, Fudan Institute for Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Fudan Institute for Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Fudan Institute for Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, ChinaLipid Cell Biology Laboratory, Centenary Institute of Cancer Medicine and Cell Biology, University of Sydney, Sydney, NSW, AustraliaDepartment of Endocrinology and Metabolism, Fudan Institute for Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, ChinaSphingolipids are a class of essential lipids, functioning as both cell membrane constituents and signaling messengers. In the sphingolipid metabolic network, ceramides serve as the central hub that is hydrolyzed to sphingosine, followed by phosphorylation to sphingosine 1-phosphate (S1P) by sphingosine kinase (SphK). SphK is regarded as a “switch” of the sphingolipid rheostat, as it catalyzes the conversion of ceramide/sphingosine to S1P, which often exhibit opposing biological roles in the cell. Besides, SphK is an important signaling enzyme that has been implicated in the regulation of a wide variety of biological functions. In recent years, an increasing body of evidence has suggested a critical role of SphK in type 2 diabetes mellitus (T2D), although a certain level of controversy remains. Herein, we review recent findings related to SphK in the field of T2D research with a focus on peripheral insulin resistance and pancreatic β-cell failure. It is expected that a comprehensive understanding of the role of SphK and the associated sphingolipids in T2D will help to identify druggable targets for future anti-diabetes therapy.https://www.frontiersin.org/articles/10.3389/fendo.2020.627076/fullinsulin resistanceβ-cellsphingolipidsphingosine 1-phosphateceramide |
| spellingShingle | Yanfei Qi Wei Wang Ziyu Song Gulibositan Aji Xin Tracy Liu Pu Xia Role of Sphingosine Kinase in Type 2 Diabetes Mellitus Frontiers in Endocrinology insulin resistance β-cell sphingolipid sphingosine 1-phosphate ceramide |
| title | Role of Sphingosine Kinase in Type 2 Diabetes Mellitus |
| title_full | Role of Sphingosine Kinase in Type 2 Diabetes Mellitus |
| title_fullStr | Role of Sphingosine Kinase in Type 2 Diabetes Mellitus |
| title_full_unstemmed | Role of Sphingosine Kinase in Type 2 Diabetes Mellitus |
| title_short | Role of Sphingosine Kinase in Type 2 Diabetes Mellitus |
| title_sort | role of sphingosine kinase in type 2 diabetes mellitus |
| topic | insulin resistance β-cell sphingolipid sphingosine 1-phosphate ceramide |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2020.627076/full |
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