Role of Sphingosine Kinase in Type 2 Diabetes Mellitus

Role of Sphingosine Kinase in Type 2 Diabetes Mellitus

Sphingolipids are a class of essential lipids, functioning as both cell membrane constituents and signaling messengers. In the sphingolipid metabolic network, ceramides serve as the central hub that is hydrolyzed to sphingosine, followed by phosphorylation to sphingosine 1-phosphate (S1P) by sphingo...

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Bibliographic Details
Main Authors: Yanfei Qi, Wei Wang, Ziyu Song, Gulibositan Aji, Xin Tracy Liu, Pu Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Endocrinology
Subjects:
insulin resistance
β-cell
sphingolipid
sphingosine 1-phosphate
ceramide
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2020.627076/full

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