Impact of 8-week cold-and warm water swimming training combined with cinnamon consumption on serum METRNL, HDAC5, and insulin resistance levels in diabetic male rats
Objective: Numerous studies have reported the beneficial effects of exercise and the use of herbal supplements in improving type 2 diabetes and insulin resistance. However, there are still many unanswered questions about the effects of cold and hot water, exercise, and herbal supplements on meteorin...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-04-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024057736 |
| _version_ | 1827261799156678656 |
|---|---|
| author | Seyed Morteza Tayebi Saleh Motaghinasab Rasoul Eslami Somayeh Ahmadabadi Aref Basereh Iman Jamhiri |
| author_facet | Seyed Morteza Tayebi Saleh Motaghinasab Rasoul Eslami Somayeh Ahmadabadi Aref Basereh Iman Jamhiri |
| author_sort | Seyed Morteza Tayebi |
| collection | DOAJ |
| description | Objective: Numerous studies have reported the beneficial effects of exercise and the use of herbal supplements in improving type 2 diabetes and insulin resistance. However, there are still many unanswered questions about the effects of cold and hot water, exercise, and herbal supplements on meteorine-like protein (METRNL), which is considered one of the key factors influencing insulin resistance improvement in this condition. Hence, the current study aimed to address these knowledge gaps and investigate the effects of 8 weeks of warm and cold-water swimming exercise with cinnamon consumption on serum levels of METRNL, histone deacetylase-5 (HDAC5), and insulin resistance in diabetic male rats. Methods: For this purpose, 70 diabetic male rats were randomly divided into seven groups (10 rats in each group) H ealthy control (HC) , Diabetic control , swimming training in cold water (temperature 5 °C) , swimming training at 5 °C + cinnamon consumption (200 mg/kg body weight) , swimming training in warm water (temperature 36-35 °C) , swimming training in warm water (temperature 36-35 °C) + consumption of cinnamon, and consumption of cinnamon only. Results: The present study revealed a significant increase in serum METRNL concentration in the cold-water swimming + cinnamon consumption group (p < 0.05). However, no significant changes were observed in insulin levels and HOMA-IR across the different groups (p > 0.05). Additionally, noteworthy findings included a significant reduction in HDAC5 levels in both the cold-water swimming group and the cold-water swimming + cinnamon consumption group, as well as a significant decrease in fasting blood sugar (FBS) levels in all groups compared to the HC group (p < 0.05). Conclusions: The results of the present study demonstrate that the combination of cold-water swimming exercises and cinnamon extract consumption led to notable increases in serum METRNL concentration. Additionally, significant reductions were observed in HDAC5 and FBS levels. These findings highlight the potential effectiveness and benefits of the combination of cold-water swimming exercises and cinnamon extract consumption as an approach to improve diabetes-related indices. |
| first_indexed | 2024-04-24T07:37:48Z |
| format | Article |
| id | doaj.art-d3d068bca9314334a4285a664506f688 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2025-03-22T03:04:07Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-d3d068bca9314334a4285a664506f6882024-05-01T05:09:22ZengElsevierHeliyon2405-84402024-04-01108e29742Impact of 8-week cold-and warm water swimming training combined with cinnamon consumption on serum METRNL, HDAC5, and insulin resistance levels in diabetic male ratsSeyed Morteza Tayebi0Saleh Motaghinasab1Rasoul Eslami2Somayeh Ahmadabadi3Aref Basereh4Iman Jamhiri5Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Allameh Tabataba'i University, Tehran, Iran; Corresponding author.Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Allameh Tabataba'i University, Tehran, IranDepartment of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Allameh Tabataba'i University, Tehran, IranDepartment of Physical Education and Sports Sciences, Farhangian University, P.O. Box 14665-889, Tehran, Iran; Corresponding author. Department of Physical Education and Sports Sciences, Farhangian University, P.O. Box 14665-889, Tehran, Iran.Faculty of Sports Science, Kharazmi University, Tehran, IranStem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, IranObjective: Numerous studies have reported the beneficial effects of exercise and the use of herbal supplements in improving type 2 diabetes and insulin resistance. However, there are still many unanswered questions about the effects of cold and hot water, exercise, and herbal supplements on meteorine-like protein (METRNL), which is considered one of the key factors influencing insulin resistance improvement in this condition. Hence, the current study aimed to address these knowledge gaps and investigate the effects of 8 weeks of warm and cold-water swimming exercise with cinnamon consumption on serum levels of METRNL, histone deacetylase-5 (HDAC5), and insulin resistance in diabetic male rats. Methods: For this purpose, 70 diabetic male rats were randomly divided into seven groups (10 rats in each group) H ealthy control (HC) , Diabetic control , swimming training in cold water (temperature 5 °C) , swimming training at 5 °C + cinnamon consumption (200 mg/kg body weight) , swimming training in warm water (temperature 36-35 °C) , swimming training in warm water (temperature 36-35 °C) + consumption of cinnamon, and consumption of cinnamon only. Results: The present study revealed a significant increase in serum METRNL concentration in the cold-water swimming + cinnamon consumption group (p < 0.05). However, no significant changes were observed in insulin levels and HOMA-IR across the different groups (p > 0.05). Additionally, noteworthy findings included a significant reduction in HDAC5 levels in both the cold-water swimming group and the cold-water swimming + cinnamon consumption group, as well as a significant decrease in fasting blood sugar (FBS) levels in all groups compared to the HC group (p < 0.05). Conclusions: The results of the present study demonstrate that the combination of cold-water swimming exercises and cinnamon extract consumption led to notable increases in serum METRNL concentration. Additionally, significant reductions were observed in HDAC5 and FBS levels. These findings highlight the potential effectiveness and benefits of the combination of cold-water swimming exercises and cinnamon extract consumption as an approach to improve diabetes-related indices.http://www.sciencedirect.com/science/article/pii/S2405844024057736CinnamonDiabetesHDAC5METRNLInsulin resistanceSwimming |
| spellingShingle | Seyed Morteza Tayebi Saleh Motaghinasab Rasoul Eslami Somayeh Ahmadabadi Aref Basereh Iman Jamhiri Impact of 8-week cold-and warm water swimming training combined with cinnamon consumption on serum METRNL, HDAC5, and insulin resistance levels in diabetic male rats Heliyon Cinnamon Diabetes HDAC5 METRNL Insulin resistance Swimming |
| title | Impact of 8-week cold-and warm water swimming training combined with cinnamon consumption on serum METRNL, HDAC5, and insulin resistance levels in diabetic male rats |
| title_full | Impact of 8-week cold-and warm water swimming training combined with cinnamon consumption on serum METRNL, HDAC5, and insulin resistance levels in diabetic male rats |
| title_fullStr | Impact of 8-week cold-and warm water swimming training combined with cinnamon consumption on serum METRNL, HDAC5, and insulin resistance levels in diabetic male rats |
| title_full_unstemmed | Impact of 8-week cold-and warm water swimming training combined with cinnamon consumption on serum METRNL, HDAC5, and insulin resistance levels in diabetic male rats |
| title_short | Impact of 8-week cold-and warm water swimming training combined with cinnamon consumption on serum METRNL, HDAC5, and insulin resistance levels in diabetic male rats |
| title_sort | impact of 8 week cold and warm water swimming training combined with cinnamon consumption on serum metrnl hdac5 and insulin resistance levels in diabetic male rats |
| topic | Cinnamon Diabetes HDAC5 METRNL Insulin resistance Swimming |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024057736 |
| work_keys_str_mv | AT seyedmortezatayebi impactof8weekcoldandwarmwaterswimmingtrainingcombinedwithcinnamonconsumptiononserummetrnlhdac5andinsulinresistancelevelsindiabeticmalerats AT salehmotaghinasab impactof8weekcoldandwarmwaterswimmingtrainingcombinedwithcinnamonconsumptiononserummetrnlhdac5andinsulinresistancelevelsindiabeticmalerats AT rasouleslami impactof8weekcoldandwarmwaterswimmingtrainingcombinedwithcinnamonconsumptiononserummetrnlhdac5andinsulinresistancelevelsindiabeticmalerats AT somayehahmadabadi impactof8weekcoldandwarmwaterswimmingtrainingcombinedwithcinnamonconsumptiononserummetrnlhdac5andinsulinresistancelevelsindiabeticmalerats AT arefbasereh impactof8weekcoldandwarmwaterswimmingtrainingcombinedwithcinnamonconsumptiononserummetrnlhdac5andinsulinresistancelevelsindiabeticmalerats AT imanjamhiri impactof8weekcoldandwarmwaterswimmingtrainingcombinedwithcinnamonconsumptiononserummetrnlhdac5andinsulinresistancelevelsindiabeticmalerats |