Supplementation of cassava fiber counteracts high sugar diet-induced metabolic syndromes by maintaining glucose and lipid homeostasis
Metabolic disorders characterized by different physiological syndromes are affecting modern society, particularly the people who live in urban areas. High sugar diet (HSD) consumption is associated with the development of metabolic diseases such as diabetes and obesity. Dietary fiber has been linked...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Farm to Fork Foundation
2022-06-01
|
| Series: | Fundamental and Applied Agriculture |
| Subjects: | |
| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=41875 |
| _version_ | 1798031900170780672 |
|---|---|
| author | Rakhi Chacrabati Md. Kamrul Hasan Kazal Ohi Alam Romana Jahan Moon Khadiza Khatun Chayon Goswami |
| author_facet | Rakhi Chacrabati Md. Kamrul Hasan Kazal Ohi Alam Romana Jahan Moon Khadiza Khatun Chayon Goswami |
| author_sort | Rakhi Chacrabati |
| collection | DOAJ |
| description | Metabolic disorders characterized by different physiological syndromes are affecting modern society, particularly the people who live in urban areas. High sugar diet (HSD) consumption is associated with the development of metabolic diseases such as diabetes and obesity. Dietary fiber has been linked to a variety of health benefits, including obesity prevention, better glucose homeostasis, and control of blood lipid profile. Therefore, we designed this experiment to determine the efficacy of cassava fiber (CF) in preventing the development of diabetes and obesity caused by HSD. Swiss albino male mice were fed with CF in supplementation with or without HSD. In comparison to a high sugar diet group, CF supplementation steadily reduced food intake. Though it was insignificant CF supplementation attenuated the increase in body weight due to HSD consumption. From the intraperitoneal glucose tolerance test (ipGTT), it was revealed that CF supplementation improved glucose tolerance after a glucose (2mg/kg BW) challenge and also showed a significant decrease in area under the curve (AUC). Moreover, CF supplementation remarkably lowered the LDL-cholesterol level of the HSD-fed mice. Overall, our present study demonstrates that consumption of a CF-rich diet helps to maintain glucose homeostasis and prevent the development of metabolic syndromes associated with diabetes and obesity. [Fundam Appl Agric 2022; 7(2.000): 94-103] |
| first_indexed | 2024-04-11T20:05:09Z |
| format | Article |
| id | doaj.art-d3d3f5fa063f432e8406821d42ad9923 |
| institution | Directory Open Access Journal |
| issn | 2518-2021 |
| language | English |
| last_indexed | 2024-04-11T20:05:09Z |
| publishDate | 2022-06-01 |
| publisher | Farm to Fork Foundation |
| record_format | Article |
| series | Fundamental and Applied Agriculture |
| spelling | doaj.art-d3d3f5fa063f432e8406821d42ad99232022-12-22T04:05:21ZengFarm to Fork FoundationFundamental and Applied Agriculture2518-20212022-06-01729410310.5455/faa.4187541875Supplementation of cassava fiber counteracts high sugar diet-induced metabolic syndromes by maintaining glucose and lipid homeostasisRakhi Chacrabati0Md. Kamrul Hasan Kazal1Ohi Alam2Romana Jahan Moon3Khadiza Khatun4Chayon Goswami5Interdisciplinary Institute for Food Security, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University Department of Biochemistry and Molecular Biology, Bangladesh Agricultural UniversityMetabolic disorders characterized by different physiological syndromes are affecting modern society, particularly the people who live in urban areas. High sugar diet (HSD) consumption is associated with the development of metabolic diseases such as diabetes and obesity. Dietary fiber has been linked to a variety of health benefits, including obesity prevention, better glucose homeostasis, and control of blood lipid profile. Therefore, we designed this experiment to determine the efficacy of cassava fiber (CF) in preventing the development of diabetes and obesity caused by HSD. Swiss albino male mice were fed with CF in supplementation with or without HSD. In comparison to a high sugar diet group, CF supplementation steadily reduced food intake. Though it was insignificant CF supplementation attenuated the increase in body weight due to HSD consumption. From the intraperitoneal glucose tolerance test (ipGTT), it was revealed that CF supplementation improved glucose tolerance after a glucose (2mg/kg BW) challenge and also showed a significant decrease in area under the curve (AUC). Moreover, CF supplementation remarkably lowered the LDL-cholesterol level of the HSD-fed mice. Overall, our present study demonstrates that consumption of a CF-rich diet helps to maintain glucose homeostasis and prevent the development of metabolic syndromes associated with diabetes and obesity. [Fundam Appl Agric 2022; 7(2.000): 94-103]http://www.ejmanager.com/fulltextpdf.php?mno=41875cassava; dietary fiber; high sugar diet; diabetes; obesity |
| spellingShingle | Rakhi Chacrabati Md. Kamrul Hasan Kazal Ohi Alam Romana Jahan Moon Khadiza Khatun Chayon Goswami Supplementation of cassava fiber counteracts high sugar diet-induced metabolic syndromes by maintaining glucose and lipid homeostasis Fundamental and Applied Agriculture cassava; dietary fiber; high sugar diet; diabetes; obesity |
| title | Supplementation of cassava fiber counteracts high sugar diet-induced metabolic syndromes by maintaining glucose and lipid homeostasis |
| title_full | Supplementation of cassava fiber counteracts high sugar diet-induced metabolic syndromes by maintaining glucose and lipid homeostasis |
| title_fullStr | Supplementation of cassava fiber counteracts high sugar diet-induced metabolic syndromes by maintaining glucose and lipid homeostasis |
| title_full_unstemmed | Supplementation of cassava fiber counteracts high sugar diet-induced metabolic syndromes by maintaining glucose and lipid homeostasis |
| title_short | Supplementation of cassava fiber counteracts high sugar diet-induced metabolic syndromes by maintaining glucose and lipid homeostasis |
| title_sort | supplementation of cassava fiber counteracts high sugar diet induced metabolic syndromes by maintaining glucose and lipid homeostasis |
| topic | cassava; dietary fiber; high sugar diet; diabetes; obesity |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=41875 |
| work_keys_str_mv | AT rakhichacrabati supplementationofcassavafibercounteractshighsugardietinducedmetabolicsyndromesbymaintainingglucoseandlipidhomeostasis AT mdkamrulhasankazal supplementationofcassavafibercounteractshighsugardietinducedmetabolicsyndromesbymaintainingglucoseandlipidhomeostasis AT ohialam supplementationofcassavafibercounteractshighsugardietinducedmetabolicsyndromesbymaintainingglucoseandlipidhomeostasis AT romanajahanmoon supplementationofcassavafibercounteractshighsugardietinducedmetabolicsyndromesbymaintainingglucoseandlipidhomeostasis AT khadizakhatun supplementationofcassavafibercounteractshighsugardietinducedmetabolicsyndromesbymaintainingglucoseandlipidhomeostasis AT chayongoswami supplementationofcassavafibercounteractshighsugardietinducedmetabolicsyndromesbymaintainingglucoseandlipidhomeostasis |