A proof-of-concept study on the genomic evolution of Sars-Cov-2 in molnupiravir-treated, paxlovid-treated and drug-naïve patients
A proof-of-concept study on the genomic evolution of SARS-CoV-2 during antiviral treatment reveals that Molnupiravir induces a higher in vivo intra-host variability compared to Paxlovid and drug-naive.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-04322-8 |
| _version_ | 1828164785630347264 |
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| author | Claudia Alteri Valeria Fox Rossana Scutari Giulia Jole Burastero Sara Volpi Matteo Faltoni Vanessa Fini Annarita Granaglia Sara Esperti Altea Gallerani Valentino Costabile Beatrice Fontana Erica Franceschini Marianna Meschiari Andrea Campana Stefania Bernardi Alberto Villani Paola Bernaschi Cristina Russo Giovanni Guaraldi Cristina Mussini Carlo Federico Perno |
| author_facet | Claudia Alteri Valeria Fox Rossana Scutari Giulia Jole Burastero Sara Volpi Matteo Faltoni Vanessa Fini Annarita Granaglia Sara Esperti Altea Gallerani Valentino Costabile Beatrice Fontana Erica Franceschini Marianna Meschiari Andrea Campana Stefania Bernardi Alberto Villani Paola Bernaschi Cristina Russo Giovanni Guaraldi Cristina Mussini Carlo Federico Perno |
| author_sort | Claudia Alteri |
| collection | DOAJ |
| description | A proof-of-concept study on the genomic evolution of SARS-CoV-2 during antiviral treatment reveals that Molnupiravir induces a higher in vivo intra-host variability compared to Paxlovid and drug-naive. |
| first_indexed | 2024-04-12T01:32:24Z |
| format | Article |
| id | doaj.art-d3d48f1280234ca4a779a922ba81a3d6 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-12T01:32:24Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-d3d48f1280234ca4a779a922ba81a3d62022-12-22T03:53:27ZengNature PortfolioCommunications Biology2399-36422022-12-015111210.1038/s42003-022-04322-8A proof-of-concept study on the genomic evolution of Sars-Cov-2 in molnupiravir-treated, paxlovid-treated and drug-naïve patientsClaudia Alteri0Valeria Fox1Rossana Scutari2Giulia Jole Burastero3Sara Volpi4Matteo Faltoni5Vanessa Fini6Annarita Granaglia7Sara Esperti8Altea Gallerani9Valentino Costabile10Beatrice Fontana11Erica Franceschini12Marianna Meschiari13Andrea Campana14Stefania Bernardi15Alberto Villani16Paola Bernaschi17Cristina Russo18Giovanni Guaraldi19Cristina Mussini20Carlo Federico Perno21Multimodal Research Area, Microbiology and Diagnostics of Immunology Unit, Bambino Gesù Children Hospital IRCCSMultimodal Research Area, Microbiology and Diagnostics of Immunology Unit, Bambino Gesù Children Hospital IRCCSMultimodal Research Area, Microbiology and Diagnostics of Immunology Unit, Bambino Gesù Children Hospital IRCCSDepartment of Infectious Diseases, University of Modena and Reggio EmiliaDepartment of Infectious Diseases, University of Modena and Reggio EmiliaDepartment of Infectious Diseases, University of Modena and Reggio EmiliaMultimodal Research Area, Microbiology and Diagnostics of Immunology Unit, Bambino Gesù Children Hospital IRCCSMultimodal Research Area, Microbiology and Diagnostics of Immunology Unit, Bambino Gesù Children Hospital IRCCSDepartment of Infectious Diseases, University of Modena and Reggio EmiliaDepartment of Infectious Diseases, University of Modena and Reggio EmiliaMultimodal Research Area, Microbiology and Diagnostics of Immunology Unit, Bambino Gesù Children Hospital IRCCSDepartment of Infectious Diseases, University of Modena and Reggio EmiliaDepartment of Infectious Diseases, AOU ModenaDepartment of Infectious Diseases, AOU ModenaAcademic Department of Pediatrics, Bambino Gesù Children’s Hospital IRCCSAcademic Department of Pediatrics, Bambino Gesù Children’s Hospital IRCCSAcademic Department of Pediatrics, Bambino Gesù Children’s Hospital IRCCSMultimodal Research Area, Microbiology and Diagnostics of Immunology Unit, Bambino Gesù Children Hospital IRCCSMultimodal Research Area, Microbiology and Diagnostics of Immunology Unit, Bambino Gesù Children Hospital IRCCSDepartment of Infectious Diseases, University of Modena and Reggio EmiliaDepartment of Infectious Diseases, University of Modena and Reggio EmiliaMultimodal Research Area, Microbiology and Diagnostics of Immunology Unit, Bambino Gesù Children Hospital IRCCSA proof-of-concept study on the genomic evolution of SARS-CoV-2 during antiviral treatment reveals that Molnupiravir induces a higher in vivo intra-host variability compared to Paxlovid and drug-naive.https://doi.org/10.1038/s42003-022-04322-8 |
| spellingShingle | Claudia Alteri Valeria Fox Rossana Scutari Giulia Jole Burastero Sara Volpi Matteo Faltoni Vanessa Fini Annarita Granaglia Sara Esperti Altea Gallerani Valentino Costabile Beatrice Fontana Erica Franceschini Marianna Meschiari Andrea Campana Stefania Bernardi Alberto Villani Paola Bernaschi Cristina Russo Giovanni Guaraldi Cristina Mussini Carlo Federico Perno A proof-of-concept study on the genomic evolution of Sars-Cov-2 in molnupiravir-treated, paxlovid-treated and drug-naïve patients Communications Biology |
| title | A proof-of-concept study on the genomic evolution of Sars-Cov-2 in molnupiravir-treated, paxlovid-treated and drug-naïve patients |
| title_full | A proof-of-concept study on the genomic evolution of Sars-Cov-2 in molnupiravir-treated, paxlovid-treated and drug-naïve patients |
| title_fullStr | A proof-of-concept study on the genomic evolution of Sars-Cov-2 in molnupiravir-treated, paxlovid-treated and drug-naïve patients |
| title_full_unstemmed | A proof-of-concept study on the genomic evolution of Sars-Cov-2 in molnupiravir-treated, paxlovid-treated and drug-naïve patients |
| title_short | A proof-of-concept study on the genomic evolution of Sars-Cov-2 in molnupiravir-treated, paxlovid-treated and drug-naïve patients |
| title_sort | proof of concept study on the genomic evolution of sars cov 2 in molnupiravir treated paxlovid treated and drug naive patients |
| url | https://doi.org/10.1038/s42003-022-04322-8 |
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