Hemodynamic influence of design parameters of novel venous valve prostheses
Venous ulcers of the lower limbs are one clinical manifestation of chronic venous insufficiency. Currently, there is no venous valve prosthesis available. This study presents novel venous valve prostheses made of threedimensional electrospun fibrous nonwoven leaflets. The aim of this study was to pr...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2018-09-01
|
| Series: | Current Directions in Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cdbme-2018-0037 |
| _version_ | 1797989461405990912 |
|---|---|
| author | Stiehm Michael Kohse Stefanie Schümann Kerstin Kaule Sebastian Siewert Stefan Oldenburg Jan Keiler Jonas Grabow Niels Wree Andreas Schmitz Klaus-Peter |
| author_facet | Stiehm Michael Kohse Stefanie Schümann Kerstin Kaule Sebastian Siewert Stefan Oldenburg Jan Keiler Jonas Grabow Niels Wree Andreas Schmitz Klaus-Peter |
| author_sort | Stiehm Michael |
| collection | DOAJ |
| description | Venous ulcers of the lower limbs are one clinical manifestation of chronic venous insufficiency. Currently, there is no venous valve prosthesis available. This study presents novel venous valve prostheses made of threedimensional electrospun fibrous nonwoven leaflets. The aim of this study was to prove the feasibility of the manufacturing process as well as to investigate design features of the venous valve prostheses from a hemodynamic point of view. An adapted pulse duplicator system (ViVitrolabs, Victoria, BC, CA) was used for characterization of the hydrodynamic performance. For eight different venous valve prototypes flow rate, effective orifice area and regurgitation fraction was investigated in vitro. In particular, tricusp valve designs showed an up to 40% higher effective orifice area as well as 15% higher maximum flowrate compared to bicusp valve designs. However, the regurgitation fraction of the bicusp valve designs is up to 86% lower compared to tricusp valve. Additionally, the hemodynamic performance of the tricuspid valves showed a high sensitivity regarding the leaflet length. Bicuspid valves are less sensitive to changes of design parameters, more sufficient and therefore highly reliable. |
| first_indexed | 2024-04-11T08:19:33Z |
| format | Article |
| id | doaj.art-d3d529ea0c9c4260b6156c6b0f8f80eb |
| institution | Directory Open Access Journal |
| issn | 2364-5504 |
| language | English |
| last_indexed | 2024-04-11T08:19:33Z |
| publishDate | 2018-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj.art-d3d529ea0c9c4260b6156c6b0f8f80eb2022-12-22T04:34:59ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042018-09-014114915110.1515/cdbme-2018-0037cdbme-2018-0037Hemodynamic influence of design parameters of novel venous valve prosthesesStiehm Michael0Kohse Stefanie1Schümann Kerstin2Kaule Sebastian3Siewert Stefan4Oldenburg Jan5Keiler Jonas6Grabow Niels7Wree Andreas8Schmitz Klaus-Peter9Institute for ImplantTechnology and Biomaterials e.V., Friedrich- Barnewitz-Str. 4, 18119 Rostock-Warnemünde, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich- Barnewitz-Str. 4, 18119 Rostock-Warnemünde, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich- Barnewitz-Str. 4, 18119 Rostock-Warnemünde, GermanyInstitute for ImplantTechnology and Biomaterials e.V., Friedrich- Barnewitz-Str. 4, 18119 Rostock-Warnemünde, GermanyInstitute for ImplantTechnology and Biomaterials e.V., Friedrich- Barnewitz-Str. 4, 18119 Rostock-Warnemünde, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich- Barnewitz-Str. 4, 18119 Rostock-Warnemünde, GermanyDepartment of Anatomy, Rostock University Medical Center, Gertrudenstr. 9, 18057Rostock, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich- Barnewitz-Str. 4, 18119 Rostock-Warnemünde, GermanyDepartment of Anatomy, Rostock University Medical Center, Gertrudenstr. 9, 18057Rostock, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich- Barnewitz-Str. 4, 18119 Rostock-Warnemünde, GermanyVenous ulcers of the lower limbs are one clinical manifestation of chronic venous insufficiency. Currently, there is no venous valve prosthesis available. This study presents novel venous valve prostheses made of threedimensional electrospun fibrous nonwoven leaflets. The aim of this study was to prove the feasibility of the manufacturing process as well as to investigate design features of the venous valve prostheses from a hemodynamic point of view. An adapted pulse duplicator system (ViVitrolabs, Victoria, BC, CA) was used for characterization of the hydrodynamic performance. For eight different venous valve prototypes flow rate, effective orifice area and regurgitation fraction was investigated in vitro. In particular, tricusp valve designs showed an up to 40% higher effective orifice area as well as 15% higher maximum flowrate compared to bicusp valve designs. However, the regurgitation fraction of the bicusp valve designs is up to 86% lower compared to tricusp valve. Additionally, the hemodynamic performance of the tricuspid valves showed a high sensitivity regarding the leaflet length. Bicuspid valves are less sensitive to changes of design parameters, more sufficient and therefore highly reliable.https://doi.org/10.1515/cdbme-2018-0037venous valve prostheseselectrospinninghemodynamicregurgitation fraction |
| spellingShingle | Stiehm Michael Kohse Stefanie Schümann Kerstin Kaule Sebastian Siewert Stefan Oldenburg Jan Keiler Jonas Grabow Niels Wree Andreas Schmitz Klaus-Peter Hemodynamic influence of design parameters of novel venous valve prostheses Current Directions in Biomedical Engineering venous valve prostheses electrospinning hemodynamic regurgitation fraction |
| title | Hemodynamic influence of design parameters of novel venous valve prostheses |
| title_full | Hemodynamic influence of design parameters of novel venous valve prostheses |
| title_fullStr | Hemodynamic influence of design parameters of novel venous valve prostheses |
| title_full_unstemmed | Hemodynamic influence of design parameters of novel venous valve prostheses |
| title_short | Hemodynamic influence of design parameters of novel venous valve prostheses |
| title_sort | hemodynamic influence of design parameters of novel venous valve prostheses |
| topic | venous valve prostheses electrospinning hemodynamic regurgitation fraction |
| url | https://doi.org/10.1515/cdbme-2018-0037 |
| work_keys_str_mv | AT stiehmmichael hemodynamicinfluenceofdesignparametersofnovelvenousvalveprostheses AT kohsestefanie hemodynamicinfluenceofdesignparametersofnovelvenousvalveprostheses AT schumannkerstin hemodynamicinfluenceofdesignparametersofnovelvenousvalveprostheses AT kaulesebastian hemodynamicinfluenceofdesignparametersofnovelvenousvalveprostheses AT siewertstefan hemodynamicinfluenceofdesignparametersofnovelvenousvalveprostheses AT oldenburgjan hemodynamicinfluenceofdesignparametersofnovelvenousvalveprostheses AT keilerjonas hemodynamicinfluenceofdesignparametersofnovelvenousvalveprostheses AT grabowniels hemodynamicinfluenceofdesignparametersofnovelvenousvalveprostheses AT wreeandreas hemodynamicinfluenceofdesignparametersofnovelvenousvalveprostheses AT schmitzklauspeter hemodynamicinfluenceofdesignparametersofnovelvenousvalveprostheses |