The Timing and Magnitude of the Type I Interferon Response Are Correlated with Disease Tolerance in Arbovirus Infection

The Timing and Magnitude of the Type I Interferon Response Are Correlated with Disease Tolerance in Arbovirus Infection

ABSTRACT Infected hosts possess two alternative strategies to protect themselves against the negative impact of virus infections: resistance, used to abrogate virus replication, and disease tolerance, used to avoid tissue damage without controlling viral burden. The principles governing pathogen res...

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Bibliographic Details
Main Authors: Alexandra Hardy, Siddharth Bakshi, Wilhelm Furnon, Oscar MacLean, Quan Gu, Margus Varjak, Mariana Varela, Muhamad Afiq Aziz, Andrew E. Shaw, Rute Maria Pinto, Natalia Cameron Ruiz, Catrina Mullan, Aislynn E. Taggart, Ana Da Silva Filipe, Richard E. Randall, Sam J. Wilson, Meredith E. Stewart, Massimo Palmarini
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:mBio
Subjects:
arbovirus
disease tolerance
innate immunity
interferons
Online Access:https://journals.asm.org/doi/10.1128/mbio.00101-23

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