Association between Iron Intake and Diabetic Peripheral Neuropathy in Type 2 Diabetes: Significance of Iron Intake and the Ratio between Iron Intake and Polyunsaturated Fatty Acids Intake
We aimed to investigate the association of iron and polyunsaturated fatty acid (PUFA) intake with diabetic peripheral neuropathy (DPN) in individuals with type 2 diabetes. This cross-sectional study included 147 individuals with type 2 diabetes. Dietary intake was assessed using three-day food recor...
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| Format: | Article |
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MDPI AG
2020-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/11/3365 |
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| author | Kyuho Kim YoonJu Song Tae Jung Oh Sung Hee Choi Hak Chul Jang |
| author_facet | Kyuho Kim YoonJu Song Tae Jung Oh Sung Hee Choi Hak Chul Jang |
| author_sort | Kyuho Kim |
| collection | DOAJ |
| description | We aimed to investigate the association of iron and polyunsaturated fatty acid (PUFA) intake with diabetic peripheral neuropathy (DPN) in individuals with type 2 diabetes. This cross-sectional study included 147 individuals with type 2 diabetes. Dietary intake was assessed using three-day food records. DPN was diagnosed on the basis of a Michigan Neuropathy Screening Instrument—Physical Examination score ≥2.5. Adjusted for total energy intake, iron intake was significantly higher in individuals with DPN than in those without DPN (10.9 ± 4.0 mg vs. 9.9 ± 3.6 mg, <i>p</i> = 0.041). In addition, the iron/PUFA ratio was significantly higher in individuals with DPN (1.4 ± 0.8 vs. 1.1 ± 0.4, <i>p</i> = 0.005). Logistic regression analyses showed that iron intake (odds ratio (OR): 1.152; 95% confidence interval (CI): 1.012, 1.311) and iron/PUFA ratio (OR: 2.283; 95% CI: 1.066, 4.887) were associated with DPN after adjustment for total energy intake, sex, age, body mass index, systolic blood pressure, diabetes duration, estimated glomerular filtration rate, glycated hemoglobin, low-density lipoprotein cholesterol, and smoking. In conclusion, high dietary iron intake and an elevated iron/PUFA ratio were associated with the presence of DPN. The present study suggests the importance of the dietary pattern of iron and PUFA intake in individuals with type 2 diabetes. |
| first_indexed | 2024-03-10T15:10:03Z |
| format | Article |
| id | doaj.art-d3d8e718077943da90791395d05d4855 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T15:10:03Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-d3d8e718077943da90791395d05d48552023-11-20T19:26:41ZengMDPI AGNutrients2072-66432020-11-011211336510.3390/nu12113365Association between Iron Intake and Diabetic Peripheral Neuropathy in Type 2 Diabetes: Significance of Iron Intake and the Ratio between Iron Intake and Polyunsaturated Fatty Acids IntakeKyuho Kim0YoonJu Song1Tae Jung Oh2Sung Hee Choi3Hak Chul Jang4Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam 13620, KoreaDepartment of Food Science and Nutrition, The Catholic University of Korea, Bucheon 14662, KoreaDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam 13620, KoreaDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam 13620, KoreaDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam 13620, KoreaWe aimed to investigate the association of iron and polyunsaturated fatty acid (PUFA) intake with diabetic peripheral neuropathy (DPN) in individuals with type 2 diabetes. This cross-sectional study included 147 individuals with type 2 diabetes. Dietary intake was assessed using three-day food records. DPN was diagnosed on the basis of a Michigan Neuropathy Screening Instrument—Physical Examination score ≥2.5. Adjusted for total energy intake, iron intake was significantly higher in individuals with DPN than in those without DPN (10.9 ± 4.0 mg vs. 9.9 ± 3.6 mg, <i>p</i> = 0.041). In addition, the iron/PUFA ratio was significantly higher in individuals with DPN (1.4 ± 0.8 vs. 1.1 ± 0.4, <i>p</i> = 0.005). Logistic regression analyses showed that iron intake (odds ratio (OR): 1.152; 95% confidence interval (CI): 1.012, 1.311) and iron/PUFA ratio (OR: 2.283; 95% CI: 1.066, 4.887) were associated with DPN after adjustment for total energy intake, sex, age, body mass index, systolic blood pressure, diabetes duration, estimated glomerular filtration rate, glycated hemoglobin, low-density lipoprotein cholesterol, and smoking. In conclusion, high dietary iron intake and an elevated iron/PUFA ratio were associated with the presence of DPN. The present study suggests the importance of the dietary pattern of iron and PUFA intake in individuals with type 2 diabetes.https://www.mdpi.com/2072-6643/12/11/3365diabetic peripheral neuropathydietary intakeironpolyunsaturated fatty acidtype 2 diabetes |
| spellingShingle | Kyuho Kim YoonJu Song Tae Jung Oh Sung Hee Choi Hak Chul Jang Association between Iron Intake and Diabetic Peripheral Neuropathy in Type 2 Diabetes: Significance of Iron Intake and the Ratio between Iron Intake and Polyunsaturated Fatty Acids Intake Nutrients diabetic peripheral neuropathy dietary intake iron polyunsaturated fatty acid type 2 diabetes |
| title | Association between Iron Intake and Diabetic Peripheral Neuropathy in Type 2 Diabetes: Significance of Iron Intake and the Ratio between Iron Intake and Polyunsaturated Fatty Acids Intake |
| title_full | Association between Iron Intake and Diabetic Peripheral Neuropathy in Type 2 Diabetes: Significance of Iron Intake and the Ratio between Iron Intake and Polyunsaturated Fatty Acids Intake |
| title_fullStr | Association between Iron Intake and Diabetic Peripheral Neuropathy in Type 2 Diabetes: Significance of Iron Intake and the Ratio between Iron Intake and Polyunsaturated Fatty Acids Intake |
| title_full_unstemmed | Association between Iron Intake and Diabetic Peripheral Neuropathy in Type 2 Diabetes: Significance of Iron Intake and the Ratio between Iron Intake and Polyunsaturated Fatty Acids Intake |
| title_short | Association between Iron Intake and Diabetic Peripheral Neuropathy in Type 2 Diabetes: Significance of Iron Intake and the Ratio between Iron Intake and Polyunsaturated Fatty Acids Intake |
| title_sort | association between iron intake and diabetic peripheral neuropathy in type 2 diabetes significance of iron intake and the ratio between iron intake and polyunsaturated fatty acids intake |
| topic | diabetic peripheral neuropathy dietary intake iron polyunsaturated fatty acid type 2 diabetes |
| url | https://www.mdpi.com/2072-6643/12/11/3365 |
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