The Impact of the Gut Microbiome, Environment, and Diet in Early-Onset Colorectal Cancer Development
Traditionally considered a disease common in the older population, colorectal cancer is increasing in incidence among younger demographics. Evidence suggests that populational- and generational-level shifts in the composition of the human gut microbiome may be tied to the recent trends in gastrointe...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-02-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/16/3/676 |
| _version_ | 1797318966977232896 |
|---|---|
| author | Rui Dai Bridget N. Kelly Amarachi Ike David Berger Andrew Chan David A. Drew David Ljungman David Mutiibwa Rocco Ricciardi Gerald Tumusiime James C. Cusack |
| author_facet | Rui Dai Bridget N. Kelly Amarachi Ike David Berger Andrew Chan David A. Drew David Ljungman David Mutiibwa Rocco Ricciardi Gerald Tumusiime James C. Cusack |
| author_sort | Rui Dai |
| collection | DOAJ |
| description | Traditionally considered a disease common in the older population, colorectal cancer is increasing in incidence among younger demographics. Evidence suggests that populational- and generational-level shifts in the composition of the human gut microbiome may be tied to the recent trends in gastrointestinal carcinogenesis. This review provides an overview of current research and putative mechanisms behind the rising incidence of colorectal cancer in the younger population, with insight into future interventions that may prevent or reverse the rate of early-onset colorectal carcinoma. |
| first_indexed | 2024-03-08T04:00:02Z |
| format | Article |
| id | doaj.art-d3da08275d8144febc9027e91ce8a412 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-08T04:00:02Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-d3da08275d8144febc9027e91ce8a4122024-02-09T15:09:33ZengMDPI AGCancers2072-66942024-02-0116367610.3390/cancers16030676The Impact of the Gut Microbiome, Environment, and Diet in Early-Onset Colorectal Cancer DevelopmentRui Dai0Bridget N. Kelly1Amarachi Ike2David Berger3Andrew Chan4David A. Drew5David Ljungman6David Mutiibwa7Rocco Ricciardi8Gerald Tumusiime9James C. Cusack10Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USADepartment of Surgery, Massachusetts General Hospital, Boston, MA 02114, USADepartment of Surgery, Massachusetts General Hospital, Boston, MA 02114, USAHarvard Medical School, Harvard University, Boston, MA 02115, USAHarvard Medical School, Harvard University, Boston, MA 02115, USAHarvard Medical School, Harvard University, Boston, MA 02115, USASahlgrenska University Hospital, University of Gothenburg, 413 45 Gothenburg, SwedenDepartment of Surgery, Mbarara University of Science and Technology, Mbarara P.O. Box 1410, UgandaHarvard Medical School, Harvard University, Boston, MA 02115, USASchool of Medicine, Uganda Christian University, Mukono P.O. Box 4, UgandaHarvard Medical School, Harvard University, Boston, MA 02115, USATraditionally considered a disease common in the older population, colorectal cancer is increasing in incidence among younger demographics. Evidence suggests that populational- and generational-level shifts in the composition of the human gut microbiome may be tied to the recent trends in gastrointestinal carcinogenesis. This review provides an overview of current research and putative mechanisms behind the rising incidence of colorectal cancer in the younger population, with insight into future interventions that may prevent or reverse the rate of early-onset colorectal carcinoma.https://www.mdpi.com/2072-6694/16/3/676early-onset colorectal cancerEOCRCyoung onsetadenocarcinomagut microbiomeinflammation |
| spellingShingle | Rui Dai Bridget N. Kelly Amarachi Ike David Berger Andrew Chan David A. Drew David Ljungman David Mutiibwa Rocco Ricciardi Gerald Tumusiime James C. Cusack The Impact of the Gut Microbiome, Environment, and Diet in Early-Onset Colorectal Cancer Development Cancers early-onset colorectal cancer EOCRC young onset adenocarcinoma gut microbiome inflammation |
| title | The Impact of the Gut Microbiome, Environment, and Diet in Early-Onset Colorectal Cancer Development |
| title_full | The Impact of the Gut Microbiome, Environment, and Diet in Early-Onset Colorectal Cancer Development |
| title_fullStr | The Impact of the Gut Microbiome, Environment, and Diet in Early-Onset Colorectal Cancer Development |
| title_full_unstemmed | The Impact of the Gut Microbiome, Environment, and Diet in Early-Onset Colorectal Cancer Development |
| title_short | The Impact of the Gut Microbiome, Environment, and Diet in Early-Onset Colorectal Cancer Development |
| title_sort | impact of the gut microbiome environment and diet in early onset colorectal cancer development |
| topic | early-onset colorectal cancer EOCRC young onset adenocarcinoma gut microbiome inflammation |
| url | https://www.mdpi.com/2072-6694/16/3/676 |
| work_keys_str_mv | AT ruidai theimpactofthegutmicrobiomeenvironmentanddietinearlyonsetcolorectalcancerdevelopment AT bridgetnkelly theimpactofthegutmicrobiomeenvironmentanddietinearlyonsetcolorectalcancerdevelopment AT amarachiike theimpactofthegutmicrobiomeenvironmentanddietinearlyonsetcolorectalcancerdevelopment AT davidberger theimpactofthegutmicrobiomeenvironmentanddietinearlyonsetcolorectalcancerdevelopment AT andrewchan theimpactofthegutmicrobiomeenvironmentanddietinearlyonsetcolorectalcancerdevelopment AT davidadrew theimpactofthegutmicrobiomeenvironmentanddietinearlyonsetcolorectalcancerdevelopment AT davidljungman theimpactofthegutmicrobiomeenvironmentanddietinearlyonsetcolorectalcancerdevelopment AT davidmutiibwa theimpactofthegutmicrobiomeenvironmentanddietinearlyonsetcolorectalcancerdevelopment AT roccoricciardi theimpactofthegutmicrobiomeenvironmentanddietinearlyonsetcolorectalcancerdevelopment AT geraldtumusiime theimpactofthegutmicrobiomeenvironmentanddietinearlyonsetcolorectalcancerdevelopment AT jamesccusack theimpactofthegutmicrobiomeenvironmentanddietinearlyonsetcolorectalcancerdevelopment AT ruidai impactofthegutmicrobiomeenvironmentanddietinearlyonsetcolorectalcancerdevelopment AT bridgetnkelly impactofthegutmicrobiomeenvironmentanddietinearlyonsetcolorectalcancerdevelopment AT amarachiike impactofthegutmicrobiomeenvironmentanddietinearlyonsetcolorectalcancerdevelopment AT davidberger impactofthegutmicrobiomeenvironmentanddietinearlyonsetcolorectalcancerdevelopment AT andrewchan impactofthegutmicrobiomeenvironmentanddietinearlyonsetcolorectalcancerdevelopment AT davidadrew impactofthegutmicrobiomeenvironmentanddietinearlyonsetcolorectalcancerdevelopment AT davidljungman impactofthegutmicrobiomeenvironmentanddietinearlyonsetcolorectalcancerdevelopment AT davidmutiibwa impactofthegutmicrobiomeenvironmentanddietinearlyonsetcolorectalcancerdevelopment AT roccoricciardi impactofthegutmicrobiomeenvironmentanddietinearlyonsetcolorectalcancerdevelopment AT geraldtumusiime impactofthegutmicrobiomeenvironmentanddietinearlyonsetcolorectalcancerdevelopment AT jamesccusack impactofthegutmicrobiomeenvironmentanddietinearlyonsetcolorectalcancerdevelopment |