Toward Novel [18F]Fluorine-Labeled Radiotracers for the Imaging of α-Synuclein Fibrils

Toward Novel [18F]Fluorine-Labeled Radiotracers for the Imaging of α-Synuclein Fibrils

The accumulation of α-synuclein aggregates (α-syn) in the human brain is an occurrence common to all α-synucleinopathies. Non-invasive detection of these aggregates in a living brain with a target-specific radiotracer is not yet possible. We have recently discovered that the inclusion of a methylene...

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Bibliographic Details
Main Authors: Bright C. Uzuegbunam, Junhao Li, Wojciech Paslawski, Wolfgang Weber, Per Svenningsson, Hans Ågren, Behrooz Hooshyar Yousefi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
positron emission tomography (PET)
PET tracer development
α-synucleinopathies
α-synuclein aggregates
ruthenium-mediated deoxyfluorination
disarylbisthiazole (DABTA)
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.830704/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2022.830704/full

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