Perspectives in Sports Genomics
Human athletic performance is a complex phenotype influenced by environmental and genetic factors, with most exercise-related traits being polygenic in nature. The aim of this article is to outline some of the challenge faced by sports genetics as this relatively new field moves forward. This review...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/2/298 |
| _version_ | 1797482500804575232 |
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| author | Valentina Ginevičienė Algirdas Utkus Erinija Pranckevičienė Ekaterina A. Semenova Elliott C. R. Hall Ildus I. Ahmetov |
| author_facet | Valentina Ginevičienė Algirdas Utkus Erinija Pranckevičienė Ekaterina A. Semenova Elliott C. R. Hall Ildus I. Ahmetov |
| author_sort | Valentina Ginevičienė |
| collection | DOAJ |
| description | Human athletic performance is a complex phenotype influenced by environmental and genetic factors, with most exercise-related traits being polygenic in nature. The aim of this article is to outline some of the challenge faced by sports genetics as this relatively new field moves forward. This review summarizes recent advances in sports science and discusses the impact of the genome, epigenome and other omics (such as proteomics and metabolomics) on athletic performance. The article also highlights the current status of gene doping and examines the possibility of applying genetic knowledge to predict athletes’ injury risk and to prevent the rare but alarming occurrence of sudden deaths during sporting events. Future research in large cohorts of athletes has the potential to detect new genetic variants and to confirm the previously identified DNA variants believed to explain the natural predisposition of some individuals to certain athletic abilities and health benefits. It is hoped that this article will be useful to sports scientists who seek a greater understanding of how genetics influences exercise science and how genomic and other multi-omics approaches might support performance analysis, coaching, personalizing nutrition, rehabilitation and sports medicine, as well as the potential to develop new rationale for future scientific investigation. |
| first_indexed | 2024-03-09T22:33:16Z |
| format | Article |
| id | doaj.art-d3dbf945aca041c896e510037f276d6b |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T22:33:16Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-d3dbf945aca041c896e510037f276d6b2023-11-23T18:53:26ZengMDPI AGBiomedicines2227-90592022-01-0110229810.3390/biomedicines10020298Perspectives in Sports GenomicsValentina Ginevičienė0Algirdas Utkus1Erinija Pranckevičienė2Ekaterina A. Semenova3Elliott C. R. Hall4Ildus I. Ahmetov5Institute of Biomedical Science, Faculty of Medicine, Vilnius University, 01513 Vilnius, LithuaniaInstitute of Biomedical Science, Faculty of Medicine, Vilnius University, 01513 Vilnius, LithuaniaInstitute of Biomedical Science, Faculty of Medicine, Vilnius University, 01513 Vilnius, LithuaniaDepartment of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, RussiaResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool L3 5AF, UKDepartment of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, RussiaHuman athletic performance is a complex phenotype influenced by environmental and genetic factors, with most exercise-related traits being polygenic in nature. The aim of this article is to outline some of the challenge faced by sports genetics as this relatively new field moves forward. This review summarizes recent advances in sports science and discusses the impact of the genome, epigenome and other omics (such as proteomics and metabolomics) on athletic performance. The article also highlights the current status of gene doping and examines the possibility of applying genetic knowledge to predict athletes’ injury risk and to prevent the rare but alarming occurrence of sudden deaths during sporting events. Future research in large cohorts of athletes has the potential to detect new genetic variants and to confirm the previously identified DNA variants believed to explain the natural predisposition of some individuals to certain athletic abilities and health benefits. It is hoped that this article will be useful to sports scientists who seek a greater understanding of how genetics influences exercise science and how genomic and other multi-omics approaches might support performance analysis, coaching, personalizing nutrition, rehabilitation and sports medicine, as well as the potential to develop new rationale for future scientific investigation.https://www.mdpi.com/2227-9059/10/2/298sports sciencesports geneticsomicsbioinformaticsphysical performanceathletes |
| spellingShingle | Valentina Ginevičienė Algirdas Utkus Erinija Pranckevičienė Ekaterina A. Semenova Elliott C. R. Hall Ildus I. Ahmetov Perspectives in Sports Genomics Biomedicines sports science sports genetics omics bioinformatics physical performance athletes |
| title | Perspectives in Sports Genomics |
| title_full | Perspectives in Sports Genomics |
| title_fullStr | Perspectives in Sports Genomics |
| title_full_unstemmed | Perspectives in Sports Genomics |
| title_short | Perspectives in Sports Genomics |
| title_sort | perspectives in sports genomics |
| topic | sports science sports genetics omics bioinformatics physical performance athletes |
| url | https://www.mdpi.com/2227-9059/10/2/298 |
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