Unexpected diversity of cellular immune responses against Nef and Vif in HIV-1-infected patients who spontaneously control viral replication.
HIV-1-infected individuals who spontaneously control viral replication represent an example of successful containment of the AIDS virus. Understanding the anti-viral immune responses in these individuals may help in vaccine design. However, immune responses against HIV-1 are normally analyzed using...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2010-07-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2896403?pdf=render |
| _version_ | 1818194818001534976 |
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| author | Leandro F Tarosso Mariana M Sauer Sabri Sanabani Maria Teresa Giret Helena I Tomiyama John Sidney Shari M Piaskowski Ricardo S Diaz Ester C Sabino Alessandro Sette Jorge Kalil-Filho David I Watkins Esper G Kallas |
| author_facet | Leandro F Tarosso Mariana M Sauer Sabri Sanabani Maria Teresa Giret Helena I Tomiyama John Sidney Shari M Piaskowski Ricardo S Diaz Ester C Sabino Alessandro Sette Jorge Kalil-Filho David I Watkins Esper G Kallas |
| author_sort | Leandro F Tarosso |
| collection | DOAJ |
| description | HIV-1-infected individuals who spontaneously control viral replication represent an example of successful containment of the AIDS virus. Understanding the anti-viral immune responses in these individuals may help in vaccine design. However, immune responses against HIV-1 are normally analyzed using HIV-1 consensus B 15-mers that overlap by 11 amino acids. Unfortunately, this method may underestimate the real breadth of the cellular immune responses against the autologous sequence of the infecting virus.Here we compared cellular immune responses against nef and vif-encoded consensus B 15-mer peptides to responses against HLA class I-predicted minimal optimal epitopes from consensus B and autologous sequences in six patients who have controlled HIV-1 replication. Interestingly, our analysis revealed that three of our patients had broader cellular immune responses against HLA class I-predicted minimal optimal epitopes from either autologous viruses or from the HIV-1 consensus B sequence, when compared to responses against the 15-mer HIV-1 type B consensus peptides.This suggests that the cellular immune responses against HIV-1 in controller patients may be broader than we had previously anticipated. |
| first_indexed | 2024-12-12T01:08:20Z |
| format | Article |
| id | doaj.art-d3df9a7463ff4bb6b28e4c0f8579e159 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T01:08:20Z |
| publishDate | 2010-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d3df9a7463ff4bb6b28e4c0f8579e1592022-12-22T00:43:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-07-0157e1143610.1371/journal.pone.0011436Unexpected diversity of cellular immune responses against Nef and Vif in HIV-1-infected patients who spontaneously control viral replication.Leandro F TarossoMariana M SauerSabri SanabaniMaria Teresa GiretHelena I TomiyamaJohn SidneyShari M PiaskowskiRicardo S DiazEster C SabinoAlessandro SetteJorge Kalil-FilhoDavid I WatkinsEsper G KallasHIV-1-infected individuals who spontaneously control viral replication represent an example of successful containment of the AIDS virus. Understanding the anti-viral immune responses in these individuals may help in vaccine design. However, immune responses against HIV-1 are normally analyzed using HIV-1 consensus B 15-mers that overlap by 11 amino acids. Unfortunately, this method may underestimate the real breadth of the cellular immune responses against the autologous sequence of the infecting virus.Here we compared cellular immune responses against nef and vif-encoded consensus B 15-mer peptides to responses against HLA class I-predicted minimal optimal epitopes from consensus B and autologous sequences in six patients who have controlled HIV-1 replication. Interestingly, our analysis revealed that three of our patients had broader cellular immune responses against HLA class I-predicted minimal optimal epitopes from either autologous viruses or from the HIV-1 consensus B sequence, when compared to responses against the 15-mer HIV-1 type B consensus peptides.This suggests that the cellular immune responses against HIV-1 in controller patients may be broader than we had previously anticipated.http://europepmc.org/articles/PMC2896403?pdf=render |
| spellingShingle | Leandro F Tarosso Mariana M Sauer Sabri Sanabani Maria Teresa Giret Helena I Tomiyama John Sidney Shari M Piaskowski Ricardo S Diaz Ester C Sabino Alessandro Sette Jorge Kalil-Filho David I Watkins Esper G Kallas Unexpected diversity of cellular immune responses against Nef and Vif in HIV-1-infected patients who spontaneously control viral replication. PLoS ONE |
| title | Unexpected diversity of cellular immune responses against Nef and Vif in HIV-1-infected patients who spontaneously control viral replication. |
| title_full | Unexpected diversity of cellular immune responses against Nef and Vif in HIV-1-infected patients who spontaneously control viral replication. |
| title_fullStr | Unexpected diversity of cellular immune responses against Nef and Vif in HIV-1-infected patients who spontaneously control viral replication. |
| title_full_unstemmed | Unexpected diversity of cellular immune responses against Nef and Vif in HIV-1-infected patients who spontaneously control viral replication. |
| title_short | Unexpected diversity of cellular immune responses against Nef and Vif in HIV-1-infected patients who spontaneously control viral replication. |
| title_sort | unexpected diversity of cellular immune responses against nef and vif in hiv 1 infected patients who spontaneously control viral replication |
| url | http://europepmc.org/articles/PMC2896403?pdf=render |
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