Paradoxical role of prion protein aggregates in redox-iron induced toxicity.

Paradoxical role of prion protein aggregates in redox-iron induced toxicity.

Imbalance of iron homeostasis has been reported in sporadic Creutzfeldt-Jakob-disease (sCJD) affected human and scrapie infected animal brains, but the contribution of this phenotype to disease associated neurotoxicity is unclear.Using cell models of familial prion disorders, we demonstrate that exp...

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Bibliographic Details
Main Authors: Dola Das, Xiu Luo, Ajay Singh, Yaping Gu, Soumya Ghosh, Chinmay K Mukhopadhyay, Shu G Chen, Man-Sun Sy, Qingzhong Kong, Neena Singh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2897850?pdf=render

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