Association between prenatal androgens and cord blood androgens, a path analysis
Abstract To determine association paths between prenatal androgens and cord blood androgens. The concentrations of T, FT, DHT, DHEA and SHBG in prenatal venous blood and cord blood were measured in 342 pregnant women and their neonates. The association paths between these hormones in prenatal and co...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-25531-5 |
| _version_ | 1797958675652935680 |
|---|---|
| author | Hui Xu Qian Wang Ting Li Yuanyuan Wang Ruiyao Cao Xingwang Peng Rongying Yao Hui Han Rui Zhou Lianguo Fu |
| author_facet | Hui Xu Qian Wang Ting Li Yuanyuan Wang Ruiyao Cao Xingwang Peng Rongying Yao Hui Han Rui Zhou Lianguo Fu |
| author_sort | Hui Xu |
| collection | DOAJ |
| description | Abstract To determine association paths between prenatal androgens and cord blood androgens. The concentrations of T, FT, DHT, DHEA and SHBG in prenatal venous blood and cord blood were measured in 342 pregnant women and their neonates. The association paths between these hormones in prenatal and cord blood were revealed using Pearson correlation, multiple linear regression and path analysis. CB-T, CB-FT and CB-DHT in male neonates were higher than those in female neonates. In male and female neonates, P-FT was lower than CB-FT; however, P-DHT and P-SHBG were higher than CB-DHT and CB-SHBG, respectively. P-DHEA was lower than CB-DHEA in female newborns. In male neonates, there were association paths of P-T → CB-T → CB-FT → CB-DHT, P-T → CB-FT → CB-DHT, P-T → P-FT → CB-FT → CB-DHT, P-T → P-DHT, CB-DHEA → CB-DHT, CB-DHEA → P-DHT, and CB-DHEA → P-DHEA. In female neonates, there were association paths of P-T → CB-T → CB-FT → CB-DHT, P-T → P-FT → CB-FT → CB-DHT, P-T → P-FT → P-DHT, P-T → P-DHT, P-DHEA → P-DHT, CB-DHEA → P-DHEA, and CB-DHEA → CB-FT. There were differences in the T, FT and DHT concentrations in cord blood between male and female neonates and in the FT, DHT, DHEA, and SHBG concentrations between prenatal and cord blood. P-T and P-FT concentrations were positively associated with CB-T and CB-FT concentrations, while CB-DHEA concentration was positively associated with P-DHEA concentration. |
| first_indexed | 2024-04-11T00:23:20Z |
| format | Article |
| id | doaj.art-d3e0b32397ed447a85400da9cf5be726 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T00:23:20Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d3e0b32397ed447a85400da9cf5be7262023-01-08T12:12:02ZengNature PortfolioScientific Reports2045-23222023-01-0113111110.1038/s41598-022-25531-5Association between prenatal androgens and cord blood androgens, a path analysisHui Xu0Qian Wang1Ting Li2Yuanyuan Wang3Ruiyao Cao4Xingwang Peng5Rongying Yao6Hui Han7Rui Zhou8Lianguo Fu9Department of Child and Adolescents Health, School of Public Health, Bengbu Medical CollegeThe Third People’s Hospital of Bengbu CityMaternal and Child Health Care Center of MaanshanDepartment of Child and Adolescents Health, School of Public Health, Bengbu Medical CollegeDepartment of Child and Adolescents Health, School of Public Health, Bengbu Medical CollegeDepartment of Child and Adolescents Health, School of Public Health, Bengbu Medical CollegeDepartment of Child and Adolescents Health, School of Public Health, Bengbu Medical CollegeDepartment of Child and Adolescents Health, School of Public Health, Bengbu Medical CollegeDepartment of Pediatric, The First Affiliated Hospital of Bengbu Medical CollegeDepartment of Child and Adolescents Health, School of Public Health, Bengbu Medical CollegeAbstract To determine association paths between prenatal androgens and cord blood androgens. The concentrations of T, FT, DHT, DHEA and SHBG in prenatal venous blood and cord blood were measured in 342 pregnant women and their neonates. The association paths between these hormones in prenatal and cord blood were revealed using Pearson correlation, multiple linear regression and path analysis. CB-T, CB-FT and CB-DHT in male neonates were higher than those in female neonates. In male and female neonates, P-FT was lower than CB-FT; however, P-DHT and P-SHBG were higher than CB-DHT and CB-SHBG, respectively. P-DHEA was lower than CB-DHEA in female newborns. In male neonates, there were association paths of P-T → CB-T → CB-FT → CB-DHT, P-T → CB-FT → CB-DHT, P-T → P-FT → CB-FT → CB-DHT, P-T → P-DHT, CB-DHEA → CB-DHT, CB-DHEA → P-DHT, and CB-DHEA → P-DHEA. In female neonates, there were association paths of P-T → CB-T → CB-FT → CB-DHT, P-T → P-FT → CB-FT → CB-DHT, P-T → P-FT → P-DHT, P-T → P-DHT, P-DHEA → P-DHT, CB-DHEA → P-DHEA, and CB-DHEA → CB-FT. There were differences in the T, FT and DHT concentrations in cord blood between male and female neonates and in the FT, DHT, DHEA, and SHBG concentrations between prenatal and cord blood. P-T and P-FT concentrations were positively associated with CB-T and CB-FT concentrations, while CB-DHEA concentration was positively associated with P-DHEA concentration.https://doi.org/10.1038/s41598-022-25531-5 |
| spellingShingle | Hui Xu Qian Wang Ting Li Yuanyuan Wang Ruiyao Cao Xingwang Peng Rongying Yao Hui Han Rui Zhou Lianguo Fu Association between prenatal androgens and cord blood androgens, a path analysis Scientific Reports |
| title | Association between prenatal androgens and cord blood androgens, a path analysis |
| title_full | Association between prenatal androgens and cord blood androgens, a path analysis |
| title_fullStr | Association between prenatal androgens and cord blood androgens, a path analysis |
| title_full_unstemmed | Association between prenatal androgens and cord blood androgens, a path analysis |
| title_short | Association between prenatal androgens and cord blood androgens, a path analysis |
| title_sort | association between prenatal androgens and cord blood androgens a path analysis |
| url | https://doi.org/10.1038/s41598-022-25531-5 |
| work_keys_str_mv | AT huixu associationbetweenprenatalandrogensandcordbloodandrogensapathanalysis AT qianwang associationbetweenprenatalandrogensandcordbloodandrogensapathanalysis AT tingli associationbetweenprenatalandrogensandcordbloodandrogensapathanalysis AT yuanyuanwang associationbetweenprenatalandrogensandcordbloodandrogensapathanalysis AT ruiyaocao associationbetweenprenatalandrogensandcordbloodandrogensapathanalysis AT xingwangpeng associationbetweenprenatalandrogensandcordbloodandrogensapathanalysis AT rongyingyao associationbetweenprenatalandrogensandcordbloodandrogensapathanalysis AT huihan associationbetweenprenatalandrogensandcordbloodandrogensapathanalysis AT ruizhou associationbetweenprenatalandrogensandcordbloodandrogensapathanalysis AT lianguofu associationbetweenprenatalandrogensandcordbloodandrogensapathanalysis |