TGF-β/Smad Signalling Activation by HTRA1 Regulates the Function of Human Lens Epithelial Cells and Its Mechanism in Posterior Subcapsular Congenital Cataract

TGF-β/Smad Signalling Activation by HTRA1 Regulates the Function of Human Lens Epithelial Cells and Its Mechanism in Posterior Subcapsular Congenital Cataract

Congenital cataract is the leading cause of blindness among children worldwide. Patients with posterior subcapsular congenital cataract (PSC) in the central visual axis can result in worsening vision and stimulus deprivation amblyopia. However, the pathogenesis of PSC remains unclear. This study aim...

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Bibliographic Details
Main Authors: Xiaolei Lin, Tianke Yang, Xin Liu, Fan Fan, Xiyue Zhou, Hongzhe Li, Yi Luo
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
posterior subcapsular congenital cataract
HTRA1
TGF-β
lens epithelial cells
Online Access:https://www.mdpi.com/1422-0067/23/22/14431

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