The Role of Stress Granules and the Nonsense-mediated mRNA Decay Pathway in Antiviral Defence
Eukaryotic cells have evolved a number of survival tactics and quality control pathways that are able to counter intrinsic error-prone mechanisms and allow for maintenance of cellular homeostasis in the face of external stresses. This review will discuss the role of two cellular eukaryotic...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2019-05-01
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| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://www.chimia.ch/chimia/article/view/1247 |
| _version_ | 1818295748715872256 |
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| author | Lara Contu Silvio Steiner Volker Thiel Oliver Mühlemann |
| author_facet | Lara Contu Silvio Steiner Volker Thiel Oliver Mühlemann |
| author_sort | Lara Contu |
| collection | DOAJ |
| description |
Eukaryotic cells have evolved a number of survival tactics and quality control pathways that are able to counter intrinsic error-prone mechanisms and allow for maintenance of cellular homeostasis in the face of external stresses. This review will discuss the role of two cellular eukaryotic
processes that are vital for maintenance of cellular homeostasis – 1) the nonsense-mediated mRNA decay (NMD) pathway and 2) the transient formation of stress granules (SG) – and explore the current literature on their roles in antiviral defence. Within the NCCR RNA & Disease,
the laboratories of Proffs. O. Mühlemann and Volker Thiel teamed up to unravel the roles of NMD and SGs, and their interconnections in defending cells from alphavirus and coronavirus infections.
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| first_indexed | 2024-12-13T03:52:35Z |
| format | Article |
| id | doaj.art-d3e2638e457d4da5855d3fc38d208352 |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-12-13T03:52:35Z |
| publishDate | 2019-05-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-d3e2638e457d4da5855d3fc38d2083522022-12-22T00:00:41ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242019-05-0173510.2533/chimia.2019.374The Role of Stress Granules and the Nonsense-mediated mRNA Decay Pathway in Antiviral DefenceLara ContuSilvio SteinerVolker ThielOliver Mühlemann Eukaryotic cells have evolved a number of survival tactics and quality control pathways that are able to counter intrinsic error-prone mechanisms and allow for maintenance of cellular homeostasis in the face of external stresses. This review will discuss the role of two cellular eukaryotic processes that are vital for maintenance of cellular homeostasis – 1) the nonsense-mediated mRNA decay (NMD) pathway and 2) the transient formation of stress granules (SG) – and explore the current literature on their roles in antiviral defence. Within the NCCR RNA & Disease, the laboratories of Proffs. O. Mühlemann and Volker Thiel teamed up to unravel the roles of NMD and SGs, and their interconnections in defending cells from alphavirus and coronavirus infections. https://www.chimia.ch/chimia/article/view/1247Innate immune responseIntegrated stress responseNonsense-mediated mrna decayRna virusStress granules |
| spellingShingle | Lara Contu Silvio Steiner Volker Thiel Oliver Mühlemann The Role of Stress Granules and the Nonsense-mediated mRNA Decay Pathway in Antiviral Defence CHIMIA Innate immune response Integrated stress response Nonsense-mediated mrna decay Rna virus Stress granules |
| title | The Role of Stress Granules and the Nonsense-mediated mRNA Decay Pathway in Antiviral Defence |
| title_full | The Role of Stress Granules and the Nonsense-mediated mRNA Decay Pathway in Antiviral Defence |
| title_fullStr | The Role of Stress Granules and the Nonsense-mediated mRNA Decay Pathway in Antiviral Defence |
| title_full_unstemmed | The Role of Stress Granules and the Nonsense-mediated mRNA Decay Pathway in Antiviral Defence |
| title_short | The Role of Stress Granules and the Nonsense-mediated mRNA Decay Pathway in Antiviral Defence |
| title_sort | role of stress granules and the nonsense mediated mrna decay pathway in antiviral defence |
| topic | Innate immune response Integrated stress response Nonsense-mediated mrna decay Rna virus Stress granules |
| url | https://www.chimia.ch/chimia/article/view/1247 |
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