Small-molecule inhibitors of dengue-virus entry.

Small-molecule inhibitors of dengue-virus entry.

Flavivirus envelope protein (E) mediates membrane fusion and viral entry from endosomes. A low-pH induced, dimer-to-trimer rearrangement and reconfiguration of the membrane-proximal "stem" of the E ectodomain draw together the viral and cellular membranes. We found stem-derived peptides fr...

Full description

Bibliographic Details
Main Authors:	Aaron G Schmidt, Kyungae Lee, Priscilla L Yang, Stephen C Harrison
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Series:	PLoS Pathogens
Online Access:	http://europepmc.org/articles/PMC3320583?pdf=render

Similar Items

Correction: Small-Molecule Inhibitors of Dengue-Virus Entry.
by: Aaron G Schmidt, et al.
Published: (2019-01-01)

Peptide inhibitors of dengue-virus entry target a late-stage fusion intermediate.
by: Aaron G Schmidt, et al.
Published: (2010-04-01)

How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion
by: Luke H Chao, et al.
Published: (2018-07-01)

Small Molecule Inhibitors of Influenza Virus Entry
by: Zhaoyu Chen, et al.
Published: (2021-06-01)

A novel small molecule inhibitor of hepatitis C virus entry.
by: Carl J Baldick, et al.
Published: (2010-09-01)

Critical role for cholesterol in Lassa fever virus entry identified by a novel small molecule inhibitor targeting the viral receptor LAMP1.
by: May Kwang-Mei Wang, et al.
Published: (2018-09-01)

Dynamics and binding interactions of peptide inhibitors of dengue virus entry
by: Mohd Isa, Diyana, et al.
Published: (2019)

Small molecule grp94 inhibitors block dengue and Zika virus replication
by: Rothan, Hussin A., et al.
Published: (2019)

Evidence for distinct mechanisms of small molecule inhibitors of filovirus entry.
by: Adam Schafer, et al.
Published: (2021-02-01)

A novel small-molecule inhibitor of HIV-1 entry
by: Heredia A, et al.
Published: (2015-10-01)

Screening and functional profiling of small-molecule HIV-1 entry and fusion inhibitors
by: Giroud, C, et al.
Published: (2017)

SARS-CoV-2 Entry Inhibitors: Small Molecules and Peptides Targeting Virus or Host Cells
by: Rolando Cannalire, et al.
Published: (2020-08-01)

Develop dengue and zika virus inhibitors : simulation of small drug molecules with e-protein dimer
by: Chai, Juan Zhe
Published: (2018)

Blockade of dengue virus entry into myeloid cells by endocytic inhibitors in the presence or absence of antibodies.
by: Ana C Carro, et al.
Published: (2018-08-01)

Identification of potent small molecule inhibitors of SARS-CoV-2 entry
by: Sonia Mediouni, et al.
Published: (2022-01-01)

Novel small-molecule inhibitors of hepatitis C virus entry block viral spread and promote viral clearance in cell culture.
by: Glen A Coburn, et al.
Published: (2012-01-01)

TIM-1 Ubiquitination Mediates Dengue Virus Entry
by: Ophélie Dejarnac, et al.
Published: (2018-05-01)

Characterization of dengue virus entry into HepG2 cells
by: Suksanpaisan Lukkana, et al.
Published: (2009-02-01)

Exploration of small-molecule entry disruptors for chikungunya virus by targeting matrix remodelling associated protein
by: Avinash Kumar, et al.
Published: (2020-01-01)

Development of Small-Molecule Inhibitors Against Zika Virus Infection
by: Lili Wang, et al.
Published: (2019-12-01)

Influenza A Virus Entry Inhibitors Targeting the Hemagglutinin
by: Shuwen Liu, et al.
Published: (2013-01-01)

Micafungin Inhibits Dengue Virus Infection through the Disruption of Virus Binding, Entry, and Stability
by: Yen-Chen Chen, et al.
Published: (2021-04-01)

Structural optimization and de novo design of dengue virus entry inhibitory peptides.
by: Joshua M Costin, et al.
Published: (2010-06-01)

Anti-Dengue: A Machine Learning-Assisted Prediction of Small Molecule Antivirals against Dengue Virus and Implications in Drug Repurposing
by: Sakshi Gautam, et al.
Published: (2023-12-01)

Small molecule inhibitors of the <it>Yersinia </it>type III secretion system impair the development of <it>Chlamydia </it>after entry into host cells
by: Henriques-Normark Birgitta, et al.
Published: (2009-04-01)

Inhibition of dengue virus entry into target cells using synthetic antiviral peptides
by: Alhoot, M.A., et al.
Published: (2013)

Small Molecule Inhibitors of Ceramidases
by: Essa M. Saied, et al.
Published: (2014-06-01)

Small interference RNA profiling reveals the essential role of human membrane trafficking genes in mediating the infectious entry of dengue virus
by: Chu Justin, et al.
Published: (2010-02-01)

Inhibition of SARS-CoV-2 Entry into Host Cells Using Small Molecules
by: Kenana Al Adem, et al.
Published: (2020-12-01)

Recombinant Ns3 Serine Protease From Dengue Virus 2 As A Screen For Small Molecules
by: Ab Aziz, Nurohaida
Published: (2011)

Recombinant Ns3 Serine Protease From Dengue Virus 2 As A Screen For Small Molecules
by: Ab Aziz, Nurohaida
Published: (2011)

Metabolomics-Based Discovery of Small Molecule Biomarkers in Serum Associated with Dengue Virus Infections and Disease Outcomes.
by: Natalia V Voge, et al.
Published: (2016-02-01)

Evaluation of the Cytotoxic and Antiviral Effects of Small Molecules Selected by In Silico Studies as Inhibitors of SARS-CoV-2 Cell Entry
by: Francisca Carvalhal, et al.
Published: (2023-10-01)

Two HIV-1 variants resistant to small molecule CCR5 inhibitors differ in how they use CCR5 for entry.
by: Reem Berro, et al.
Published: (2009-08-01)

The Antiviral Activity of Varenicline against Dengue Virus Replication during the Post-Entry Stage
by: Ching-Lin Lin, et al.
Published: (2023-10-01)

Antibody-Dependent Dengue Virus Entry Modulates Cell Intrinsic Responses for Enhanced Infection
by: Candice Y. Y. Chan, et al.
Published: (2019-10-01)

Optimization of 4-Anilinoquinolines as Dengue Virus Inhibitors
by: Pei-Tzu Huang, et al.
Published: (2021-12-01)

Towards the design of dengue virus antiviral inhibitors.
by: Lescar, Julien.
Published: (2011)

Respiratory Syncytial Virus Entry Inhibitors Targeting the F Protein
by: Shibo Jiang, et al.
Published: (2013-01-01)

Identification of the dietary supplement capsaicin as an inhibitor of Lassa virus entry
by: Ke Tang, et al.
Published: (2020-05-01)