Acute Low Dose of Trazodone Recovers Glutamate Release Efficiency and mGlu2/3 Autoreceptor Impairments in the Spinal Cord of Rats Suffering From Chronic Sciatic Ligation

Acute Low Dose of Trazodone Recovers Glutamate Release Efficiency and mGlu2/3 Autoreceptor Impairments in the Spinal Cord of Rats Suffering From Chronic Sciatic Ligation

We investigated whether chronic sciatic ligation modifies the glutamate release in spinal cord nerve endings (synaptosomes) as well as the expression and the function of presynaptic release-regulating mGlu2/3 autoreceptors and 5-HT2A heteroreceptors in these particles. Synaptosomes were from the spi...

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Bibliographic Details
Main Authors:	Francesca Cisani, Alessandra Roggeri, Guendalina Olivero, Beatrice Garrone, Serena Tongiani, Francesco Paolo Di Giorgio, Anna Pittaluga
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-07-01
Series:	Frontiers in Pharmacology
Subjects:	synaptosomes mGlu2/3 receptor 5-HT2A receptor glutamate exocytosis trazodone spinal cord
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2020.01108/full

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